Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3096 | 0.3096 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0002 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1191 | 0.1191 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1191 | 0.3848 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2218 | 0.7163 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2218 | 0.7163 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2218 | 0.7163 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.3096 | 0.3096 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0002 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0002 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1191 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3096 | 0.3096 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.3096 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | geminin | 0.0197 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.3096 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0002 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.3096 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0002 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3096 | 0.3096 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2218 | 0.7163 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.3096 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3096 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3096 | 0.3096 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.3096 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0002 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.3096 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.467 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.324 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.254 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.25 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.149 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.004 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.