Detailed information for compound 1645643

Basic information

Technical information
  • TDR Targets ID: 1645643
  • Name: 2-oxo-4-(pyridin-1-ium-1-ylmethyl)chromene-3- carbonitrile iodide
  • MW: 390.175 | Formula: C16H11IN2O2
  • H donors: 0 H acceptors: 2 LogP: 2.9 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(=O)oc2c(c1C[n+]1ccccc1)cccc2.[I-]
  • InChi: 1S/C16H11N2O2.HI/c17-10-13-14(11-18-8-4-1-5-9-18)12-6-2-3-7-15(12)20-16(13)19;/h1-9H,11H2;1H/q+1;/p-1
  • InChiKey: WJPSHKAUODCUDJ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 2-oxo-4-(1-pyridin-1-iumylmethyl)-3-chromenecarbonitrile iodide
  • 2-keto-4-(pyridin-1-ium-1-ylmethyl)chromene-3-carbonitrile iodide
  • NSC648378

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0158 0.2712 0.367
Loa Loa (eye worm) hypothetical protein 0.0091 0.1351 0.1351
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.2355 1
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0196 0.0196
Brugia malayi nuclear hormone receptor family member odr-7 0.0081 0.1154 0.1063
Brugia malayi nuclear receptor RXR 0.0081 0.1154 0.1063
Brugia malayi glutaminase DH11.1 0.032 0.5995 0.5954
Schistosoma mansoni retinoic acid receptor RXR 0.0172 0.2994 0.4051
Brugia malayi ecdysteroid receptor 0.0172 0.2994 0.2922
Schistosoma mansoni hypothetical protein 0.0073 0.0992 0.1343
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Brugia malayi conserved hypotetical protein 0.0081 0.1154 0.1063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0586 0.0543
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Leishmania major hypothetical protein, conserved 0.0059 0.0706 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0172 0.2994 0.4051
Brugia malayi nuclear receptor NHR-88 0.0081 0.1154 0.1063
Loa Loa (eye worm) hypothetical protein 0.0073 0.0992 0.0992
Schistosoma mansoni hypothetical protein 0.0388 0.739 1
Brugia malayi glutathione reductase 0.0055 0.0632 0.0536
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.2994 0.2962
Schistosoma mansoni hypothetical protein 0.0073 0.0992 0.1343
Loa Loa (eye worm) glutaminase 0.032 0.5995 0.5995
Echinococcus granulosus thyroid hormone receptor alpha 0.0081 0.1154 0.1113
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.1154 0.1113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.1154 0.1113
Schistosoma mansoni hypothetical protein 0.0073 0.0992 0.1343
Loa Loa (eye worm) hypothetical protein 0.0517 1 1
Brugia malayi hypothetical protein 0.0081 0.1154 0.1063
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.1154 0.3423
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.1154 0.3423
Schistosoma mansoni nuclear receptor 0.0081 0.1154 0.1561
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0172 0.2994 0.2922
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.2355 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0464 0.0421
Brugia malayi Thioredoxin reductase 0.0055 0.0632 0.0536
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.1351 0.1262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0172 0.2994 0.2994
Brugia malayi nuclear hormone receptor family member nhr-6 0.0081 0.1154 0.1063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0172 0.2994 0.2994
Brugia malayi hypothetical protein 0.0091 0.1351 0.1262
Onchocerca volvulus 0.0081 0.1154 0.3423
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.2994 0.2922
Onchocerca volvulus Bile acid receptor homolog 0.0172 0.2994 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0172 0.2994 0.2994
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.2994 0.2922
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0047 0.0002
Brugia malayi nuclear receptor NHR-67 0.0081 0.1154 0.1063
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0081 0.1154 0.1561
Loa Loa (eye worm) hepatopoietin HPO2 0.004 0.0324 0.0324
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0091 0.1351 0.1828
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.2994 0.2962
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.2994 0.2922
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Schistosoma mansoni hypothetical protein 0.0073 0.0992 0.1343
Brugia malayi Nuclear hormone receptor-like 1 0.0172 0.2994 0.2922
Brugia malayi Bromodomain containing protein 0.0037 0.0252 0.0152
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0081 0.1154 0.1113
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0196 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0632 0.8058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.1154 0.1113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0172 0.2994 0.2994
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.1351 0.1828
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0363 0.0319
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Echinococcus granulosus GPCR family 2 0.0073 0.0992 0.0951
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0091 0.1351 0.1351
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0385 0.0342
Loa Loa (eye worm) hypothetical protein 0.0231 0.4194 0.4194
Echinococcus multilocularis muscleblind protein 0.0517 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0059 0.0706 1
Brugia malayi hypothetical protein 0.0091 0.1351 0.1262
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.004 0.0324 0.028
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0992 0.0951
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Loa Loa (eye worm) hypothetical protein 0.0091 0.1351 0.1351
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.1351 0.1262
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0632 0.059
Brugia malayi Bromodomain containing protein 0.0045 0.0419 0.0321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.1154 0.1113
Schistosoma mansoni glutaminase 0.032 0.5995 0.8113
Schistosoma mansoni bromodomain containing protein 0.0074 0.1012 0.1369
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.2069 0.8342
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0385 0.0522
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0158 0.2712 0.2712
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0081 0.1154 0.1113
Loa Loa (eye worm) hypothetical protein 0.0058 0.0686 0.0686
Echinococcus granulosus geminin 0.0388 0.739 0.7378
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Schistosoma mansoni RAR-like nuclear receptor 0.0172 0.2994 0.4051
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0045 0.0061
Schistosoma mansoni nuclear receptor nhr-48 0.0081 0.1154 0.1561
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0081 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.0706 1
Brugia malayi orphan nuclear receptor NR2E1 0.0081 0.1154 0.1063
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.034 0.0296
Onchocerca volvulus Protein ultraspiracle homolog 0.0172 0.2994 1
Schistosoma mansoni hypothetical protein 0.0388 0.739 1
Echinococcus multilocularis FTZ F1 alpha 0.0172 0.2994 0.2962
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0992 0.0951
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0632 0.8547
Onchocerca volvulus 0.0172 0.2994 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Echinococcus granulosus nuclear receptor nhr 48 0.0081 0.1154 0.1113
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.0706 1
Schistosoma mansoni coup transcription factor 0.0172 0.2994 0.4051
Loa Loa (eye worm) hypothetical protein 0.0091 0.1351 0.1351
Brugia malayi PHD-finger family protein 0.0034 0.0196 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0172 0.2994 0.4051
Leishmania major trypanothione reductase 0.0055 0.0632 0.8058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0172 0.2994 0.2994
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0172 0.2994 0.2922
Loa Loa (eye worm) hypothetical protein 0.0083 0.1188 0.1188
Echinococcus multilocularis peregrin 0.0037 0.0252 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.2994 0.2962
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0172 0.2994 0.2962
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0196 0.0151
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.2355 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0172 0.2994 1
Echinococcus granulosus peregrin 0.0037 0.0252 0.0208
Brugia malayi nuclear hormone receptor 0.0172 0.2994 0.2922
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0477
Echinococcus granulosus muscleblind protein 0.0517 1 1
Plasmodium vivax glutathione reductase, putative 0.0055 0.0632 0.8547
Plasmodium falciparum thioredoxin reductase 0.0055 0.0632 0.8547
Brugia malayi Steroid receptor seven-up type 2 0.0172 0.2994 0.2922
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.2355 1
Echinococcus granulosus FTZ F1 alpha 0.0172 0.2994 0.2962
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.004 0.0324 0.2515
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.0324 0.2515
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0927 0.0885
Mycobacterium tuberculosis Probable reductase 0.0126 0.2069 0.8342
Loa Loa (eye worm) hypothetical protein 0.0172 0.2994 0.2994
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0081 0.1154 0.1063
Echinococcus multilocularis ecdysone induced protein 78C 0.0172 0.2994 0.2962
Brugia malayi nuclear hormone receptor 0.0081 0.1154 0.1063
Onchocerca volvulus 0.0081 0.1154 0.3423
Schistosoma mansoni nuclear hormone receptor 0.0081 0.1154 0.1561
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0172 0.2994 0.2922
Brugia malayi Augmenter of liver regeneration 0.004 0.0324 0.0225
Schistosoma mansoni zinc finger protein 0.0081 0.1154 0.1561
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0196
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0196 0.0151
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.004 0.0324 0.2515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0172 0.2994 0.2994
Echinococcus multilocularis GPCR, family 2 0.0073 0.0992 0.0951
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0992 0.09
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.1755 0.1718
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0464 0.0421
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0926 0.0926
Brugia malayi steroid hormone receptor 0.0172 0.2994 0.2922
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0172 0.2994 0.2962
Toxoplasma gondii thioredoxin reductase 0.0055 0.0632 0.8547
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.004 0.0324 0.028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0172 0.2994 0.2922
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0081 0.1154 0.1113
Schistosoma mansoni nuclear receptor 0.0081 0.1154 0.1561
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0231 0.4194 0.4194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0172 0.2994 0.4051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0172 0.2994 0.2962
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0385 0.0522
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0172 0.2994 0.4051
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.1755 0.1718
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0059 0.0706 0.0706
Trichomonas vaginalis glutaminase, putative 0.032 0.5995 0.5
Brugia malayi Nuclear hormone receptor E75 0.0081 0.1154 0.1063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.2994 0.2962
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0927 0.0885
Loa Loa (eye worm) hypothetical protein 0.0517 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0231 0.4194 0.4134
Brugia malayi ecdysone receptor 0.0081 0.1154 0.1063
Loa Loa (eye worm) DR-78 0.0081 0.1154 0.1154
Schistosoma mansoni hypothetical protein 0.0034 0.0196 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0172 0.2994 0.2922
Brugia malayi Nuclear hormone receptor E75 0.0081 0.1154 0.1063
Loa Loa (eye worm) hypothetical protein 0.0091 0.1351 0.1351
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0992 0.0951
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0586 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.2994 0.2922
Trypanosoma brucei PAB1-binding protein , putative 0.0059 0.0706 1
Brugia malayi jmjC domain containing protein 0.0043 0.0385 0.0287
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.1154 0.1113
Loa Loa (eye worm) nuclear receptor NHR-67 0.0081 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.005 0.0522 0.0522
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.2069 0.8342
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0172 0.2994 0.2922
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.2994 0.2922
Loa Loa (eye worm) hypothetical protein 0.0091 0.1351 0.1351
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0091 0.1351 0.1311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0586 0.0793
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0172 0.2994 0.2962
Schistosoma mansoni nuclear hormone receptor 0.0172 0.2994 0.4051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0586 0.0543
Schistosoma mansoni jumonji domain containing protein 0.0088 0.1294 0.1751
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.1154 0.1113
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0172 0.2994 0.2962
Brugia malayi hypothetical protein 0.0081 0.1154 0.1063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0586 0.0793
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0047 0.0002
Brugia malayi tailless protein 0.0081 0.1154 0.1063
Brugia malayi hypothetical protein 0.0059 0.0706 0.0611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0992 0.0951
Brugia malayi nuclear receptor NHR-88 0.0172 0.2994 0.2922
Echinococcus granulosus ecdysone induced protein 78C 0.0172 0.2994 0.2962
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0172 0.2994 0.2962
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0231 0.4194 0.4134
Loa Loa (eye worm) hypothetical protein 0.0045 0.0421 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0172 0.2994 0.2922
Toxoplasma gondii LsmAD domain-containing protein 0.0059 0.0706 1
Trypanosoma brucei trypanothione reductase 0.0055 0.0632 0.8058
Schistosoma mansoni thyroid hormone receptor 0.0172 0.2994 0.4051
Echinococcus multilocularis muscleblind protein 1 0.0517 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.0706 1
Loa Loa (eye worm) glutaminase 2 0.032 0.5995 0.5995
Brugia malayi jmjC domain containing protein 0.0111 0.1755 0.1671
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0091 0.1351 0.1311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.2994 0.2962
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0172 0.2994 0.2962
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0172 0.2994 0.4051
Loa Loa (eye worm) steroid hormone receptor 0.0172 0.2994 0.2994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0586 0.0793
Plasmodium falciparum glutathione reductase 0.0055 0.0632 0.8547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0586 0.0543
Brugia malayi hypothetical protein 0.0038 0.0283 0.0183
Schistosoma mansoni hypothetical protein 0.0026 0.0047 0.0063
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.0706 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0081 0.1154 0.1113
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Echinococcus multilocularis geminin 0.0388 0.739 0.7378
Brugia malayi latrophilin 2 splice variant baaae 0.0158 0.2712 0.2637
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0992 0.09
Loa Loa (eye worm) nuclear hormone receptor 0.0081 0.1154 0.1154
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0992 0.0992
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0586 0.0489
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0363 0.0319
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0172 0.2994 0.4051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0586 0.0543
Brugia malayi photoreceptor-specific nuclear receptor 0.0172 0.2994 0.2922
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0172 0.2994 0.2962
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.2069 0.8342
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0172 0.2994 0.2962
Mycobacterium ulcerans glutaminase 0.032 0.5995 0.5
Giardia lamblia PHD finger protein 15 0.0034 0.0196 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.2994 0.2922
Loa Loa (eye worm) hypothetical protein 0.0081 0.1154 0.1154
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0081 0.1154 0.1561
Schistosoma mansoni thyroid hormone receptor 0.0172 0.2994 0.4051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0172 0.2994 0.4051
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.2069 0.8342
Loa Loa (eye worm) glutathione reductase 0.0055 0.0632 0.0632
Schistosoma mansoni nuclear hormone receptor 0.0081 0.1154 0.1561
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.2069 0.8342
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0632 0.059
Brugia malayi Bromodomain containing protein 0.0088 0.129 0.12
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0172 0.2994 0.2994
Toxoplasma gondii Erv1 / Alr family protein 0.004 0.0324 0.2515
Brugia malayi nuclear receptor RXR 0.0091 0.1351 0.1262

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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