Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | nuclear hormone receptor | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0095 | 0.3868 | 0.3868 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0095 | 0.3868 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.005 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.005 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0414 | 0.0414 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Echinococcus multilocularis | muscleblind protein | 0.0175 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.005 | 0.0414 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Schistosoma mansoni | coup transcription factor | 0.0095 | 0.3868 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0666 | 0.1722 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | muscleblind protein | 0.0175 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0414 | 0.0414 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | FTZ F1 alpha | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0666 | 0.0666 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0666 | 0.0666 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0095 | 0.3868 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0095 | 0.3868 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0095 | 0.3868 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0095 | 0.3868 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | thyroid hormone receptor | 0.0095 | 0.3868 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.005 | 0.0414 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0095 | 0.3868 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0095 | 0.3868 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0095 | 0.3868 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0095 | 0.3868 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0666 | 0.1722 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0666 | 0.1722 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0095 | 0.3868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0095 | 0.3868 | 0.3868 |
Schistosoma mansoni | nuclear hormone receptor | 0.0095 | 0.3868 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0095 | 0.3868 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0095 | 0.3868 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.005 | 0.0414 | 0.0414 |
Onchocerca volvulus | 0.0095 | 0.3868 | 1 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0666 | 0.0666 |
Brugia malayi | steroid hormone receptor | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | nuclear receptor RXR | 0.005 | 0.0414 | 0.0414 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0095 | 0.3868 | 0.3868 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0095 | 0.3868 | 0.3868 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0095 | 0.3868 | 0.3868 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0666 | 0.0666 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0095 | 0.3868 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.3868 | 0.3868 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.