Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0639 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0639 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0639 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0639 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0639 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0639 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0639 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0639 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0639 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0639 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0639 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0639 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0639 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0639 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0639 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0639 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0639 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0639 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0639 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0639 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DNA cleavage (functional) | = 3 ug ml-1 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | ChEMBL. | 2002456 |
DNA cleavage (functional) | = 3 ug ml-1 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | ChEMBL. | 2002456 |
IC50 (functional) | = 9 ug ml-1 | Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) | ChEMBL. | 1469702 |
MIC (functional) | = 0.003 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus (UC76) | ChEMBL. | 2002456 |
MIC (functional) | = 0.003 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pneumoniae (SV-1) | ChEMBL. | 2002456 |
MIC (functional) | = 0.006 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pyogenes (C203) | ChEMBL. | 2002456 |
MIC (functional) | = 0.01 ug ml-1 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | ChEMBL. | 1469702 |
MIC (functional) | = 0.01 ug ml-1 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | ChEMBL. | 1469702 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus (H228) | ChEMBL. | 2002456 |
MIC (functional) | = 0.025 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. faecalis (MGH-2) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | ChEMBL. | 2002456 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against gram negative organism, Escherichia cloacae (MA2646) | ChEMBL. | 2002456 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity was determined against gram negative organism, K. pneumonia(MGH-2) | ChEMBL. | 2002456 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. rettgeri. (M1771) | ChEMBL. | 2002456 |
MIC (functional) | = 0.28 ug ml-1 | Antibacterial activity against five Gram-negative bacteria | ChEMBL. | 1469702 |
MIC (functional) | = 0.8 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. aeruginosa (UI-18) | ChEMBL. | 2002456 |
PD50 (functional) | = 1.6 mg kg-1 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with S. pneumoniae | ChEMBL. | 2002456 |
PD50 (functional) | = 1.6 mg kg-1 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with S. pneumoniae | ChEMBL. | 2002456 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with S. pneumoniae | ChEMBL. | 2002456 |
PD50 (functional) | = 2.8 mg kg-1 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with S. pneumoniae | ChEMBL. | 2002456 |
PD50 (functional) | = 3 mg kg-1 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with E. coli (vogel) | ChEMBL. | 2002456 |
PD50 (functional) | = 3 mg kg-1 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with E. coli (vogel) | ChEMBL. | 2002456 |
PD50 (functional) | = 14 mg kg-1 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with E. coli (vogel) | ChEMBL. | 2002456 |
PD50 (functional) | = 14 mg kg-1 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with E. coli (vogel) | ChEMBL. | 2002456 |
Ratio (functional) | = 0.0071 | MIC ratio measured as the mean MICs of gram-positive bacteria | ChEMBL. | 2002456 |
Ratio (functional) | = 0.15 | MIC ratio measured as the mean MICs of gram-negative bacteria | ChEMBL. | 2002456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.