TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.776 | Formula: C14H16ClN7O
H donors: 2 H acceptors: 2 LogP: 3.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(/N=N\c1c(C)[nH]nc1C(=O)N/N=C/c1ccccc1Cl)C
InChi: 1S/C14H16ClN7O/c1-9-12(19-21-22(2)3)13(18-17-9)14(23)20-16-8-10-6-4-5-7-11(10)15/h4-8H,1-3H3,(H,17,18)(H,20,23)/b16-8+,21-19-
InChiKey: XCBMEIMBCIKJPR-NHWLLTSQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0557	0.0557
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0103	0.0128
Toxoplasma gondii	dgat2l1-prov protein	0.0429	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1569	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3213	0.3213
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0095	0.1992	0.1992
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.2342	0.8837
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0737	0.2912
Leishmania major	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0665	0.259
Schistosoma mansoni	hypothetical protein	0.0016	0.0103	0.0103
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.2326	0.2326
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0419	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0112	0.0651
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.1411	0.1411
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0112	0.0112
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.2326	0.2326
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0195	0.0195
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0112	0.0053
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.2636	1
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Leishmania major	DNA polymerase eta, putative	0.0077	0.1569	0.1518
Echinococcus granulosus	Immunoglobulin	0.0019	0.0162	0.02
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0053
Brugia malayi	RNA binding protein	0.0076	0.1548	0.1548
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Loa Loa (eye worm)	RecQ helicase	0.0029	0.0408	0.0408
Toxoplasma gondii	diacylglycerol acyltransferase	0.0095	0.1992	0.1992
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0755	0.0755
Schistosoma mansoni	chromobox protein	0.0071	0.1411	0.1411
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0665	0.0216
Schistosoma mansoni	vesicular amine transporter	0.0019	0.0162	0.0162
Schistosoma mansoni	chromobox protein	0.0071	0.1411	0.1411
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0019	0.0162	0.02
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0019	0.0162	0.0162
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0419	0.4456
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0112	0.0053
Leishmania major	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Onchocerca volvulus		0.005	0.0907	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.2326	1
Onchocerca volvulus		0.0278	0.6373	0.6198
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Trichomonas vaginalis	DNA helicase recq, putative	0.0029	0.0408	0.1445
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0195	0.0492
Schistosoma mansoni	ap endonuclease	0.002	0.0195	0.0195
Onchocerca volvulus		0.0429	1	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0047	0.0831	0.333
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0195	0.0326
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0195	0.0241
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0231
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.0162	0.0162
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0017	0.0112	0.0231
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.2326	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1548	0.1916
Mycobacterium ulcerans	DNA polymerase IV	0.0047	0.0831	0.3402
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0866	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.2326	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Brugia malayi	6-phosphofructokinase	0.0109	0.2326	0.2326
Entamoeba histolytica	hypothetical protein	0.0043	0.0755	0.2992
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0178	0.0178
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0195	0.0195
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0112	0.0053
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0755	0.0935
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0103	0.0128
Trypanosoma cruzi	DNA polymerase eta, putative	0.0077	0.1569	0.1518
Schistosoma mansoni	blooms syndrome DNA helicase	0.0023	0.0262	0.0262
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.2342	0.8837
Brugia malayi	hypothetical protein	0.0244	0.5567	0.5567
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0195	0.0594
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1548	0.1548
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0429	1	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0419	0.484
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.2636	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0103	0.0128
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0095	0.1992	0.1992
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1411	0.5919
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0484	0.0427
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0139
Schistosoma mansoni	tyrosine kinase	0.0013	0.0015	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Echinococcus granulosus	dna polymerase eta	0.0077	0.1569	0.1942
Echinococcus multilocularis	survival motor neuron protein 1	0.0244	0.5567	0.6892
Entamoeba histolytica	hypothetical protein	0.0043	0.0755	0.2992
Schistosoma mansoni	DNA polymerase eta	0.0077	0.1569	0.1569
Echinococcus multilocularis	dna polymerase eta	0.0077	0.1569	0.1942
Echinococcus granulosus	defective proboscis extension response	0.0019	0.0162	0.02
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.2326	0.2326
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1548	0.1548
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0095	0.1992	0.1944
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.2342	0.8837
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Brugia malayi	hypothetical protein	0.0019	0.0162	0.0162
Schistosoma mansoni	ap endonuclease	0.002	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0016	0.0103	0.0103
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0195	1
Echinococcus multilocularis	neuroglian	0.0023	0.0277	0.0342
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0195	0.2249
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0866	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0419	0.1492
Schistosoma mansoni	hypothetical protein	0.005	0.0907	0.0907
Onchocerca volvulus	Tyrosine kinase homolog	0.0284	0.6528	0.6361
Brugia malayi	6-phosphofructokinase	0.0109	0.2326	0.2326
Trypanosoma brucei	DNA polymerase IV, putative	0.0047	0.0831	0.0776
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0047	0.0831	0.2848
Brugia malayi	ImpB/MucB/SamB family protein	0.0077	0.1569	0.1569
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.2342	0.8837
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0139
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.2326	0.2326
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0112	0.0053
Schistosoma mansoni	nephrin	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0103	0.0103
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0737	0.0291
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Brugia malayi	Fibronectin type III domain containing protein	0.0019	0.0162	0.0162
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0429	1	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0112	0.1353
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.002	0.0183	0.1529
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0866	0.1071
Echinococcus granulosus	neuroglian	0.0023	0.0277	0.0342
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.2326	0.2326
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0006	0.0006
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0112	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0387	0.135
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0014	0.006	0.006
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0047	0.0831	0.0831
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0112	0.0125
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0484	0.0427
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0387	0.135
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1548	0.1548
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.2326	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0112	0.1298
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0112	0.0651
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0084	0.0025
Schistosoma mansoni	hypothetical protein	0.0205	0.4621	0.4621
Trypanosoma brucei	trypanothione reductase	0.0048	0.0866	0.081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0459	0.0459
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0103	0.0103
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Trypanosoma brucei	unspecified product	0.0047	0.0831	0.0776
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0112	0.0053
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0195	0.0492
Schistosoma mansoni	hypothetical protein	0.0016	0.0103	0.0103
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0025	0.0308	0.0382
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0045	0.0798	0.0798
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.2326	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0419	0.4456
Giardia lamblia	DNA damage repair protein	0.0014	0.006	0.0722
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.2636	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0112	0.0112
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0047	0.0831	0.0776
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.2326	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0665	0.0665
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0419	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0947	0.0947
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0112	0.1298
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1548	0.1548
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0047	0.0831	0.333
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0019	0.0162	0.0162
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0484	0.0427
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0195	0.0372
Schistosoma mansoni	hypothetical protein	0.0043	0.0755	0.0755
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0047	0.0831	0.2848
Echinococcus granulosus	twitchin	0.0023	0.0277	0.0342
Echinococcus multilocularis	geminin	0.0205	0.4621	0.572
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0103	0.0128
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1411	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0557	0.0557
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Schistosoma mansoni	cell adhesion molecule	0.0025	0.0308	0.0308
Entamoeba histolytica	hypothetical protein	0.0043	0.0755	0.2992
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.0831	0.0831
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0429	1	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0112	0.0053
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0866	0.081
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0112	0.1298
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.2342	0.052
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0112	0.0053
Schistosoma mansoni	hypothetical protein	0.0095	0.1992	0.1992
Trypanosoma brucei	DNA polymerase IV, putative	0.0047	0.0831	0.0776
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0014	0.006	0.006
Mycobacterium tuberculosis	Probable reductase	0.011	0.2342	0.8837
Giardia lamblia	DINP protein human, muc B family	0.0047	0.0831	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0304	0.7009	0.7009
Trypanosoma brucei	unspecified product	0.0032	0.0484	0.0427
Plasmodium falciparum	glutathione reductase	0.0048	0.0866	1
Echinococcus multilocularis	roundabout 2	0.003	0.0423	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Leishmania major	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.2326	0.2879
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0866	0.0866
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.1411	0.5919
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0103	0.0128
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.2326	1
Brugia malayi	phosphofructokinase	0.0109	0.2326	0.2326
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1548	0.1548
Leishmania major	trypanothione reductase	0.0048	0.0866	0.081
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.2326	0.2879
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0103	0.0128
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3171	0.3171
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Echinococcus granulosus	roundabout 2	0.003	0.0423	0.0524
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0053
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0017	0.0112	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Toxoplasma gondii	exonuclease III APE	0.002	0.0195	0.0195
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0006	0.0006
Echinococcus multilocularis	Immunoglobulin	0.0019	0.0162	0.02
Echinococcus granulosus	bloom syndrome protein	0.0029	0.0408	0.0505
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0014	0.006	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1548	0.1548
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0084	0.0025
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0947	0.0947
Echinococcus multilocularis	dna polymerase kappa	0.0047	0.0831	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0937	0.0937
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0419	0.0419
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0419	0.484
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1548	0.1548
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0195	0.0241
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.2326	0.228
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0665	0.259
Trypanosoma brucei	DNA polymerase eta, putative	0.0077	0.1569	0.1518
Mycobacterium ulcerans	DNA polymerase IV	0.0047	0.0831	0.3402
Echinococcus granulosus	chromobox protein 1	0.0071	0.1411	0.1747
Schistosoma mansoni	hypothetical protein	0.0205	0.4621	0.4621
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0195	0.0135
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0047	0.0831	0.0831
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0866	0.1071
Trypanosoma brucei	unspecified product	0.0032	0.0484	0.0427
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.2326	0.228
Brugia malayi	Thioredoxin reductase	0.0048	0.0866	0.0866
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.2326	0.228
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0866	0.0866
Mycobacterium ulcerans	hypothetical protein	0.0095	0.1992	0.8526
Leishmania major	DNA polymerase eta, putative	0.0045	0.0798	0.0742
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.2636	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0195	0.0492
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0195	0.1672
Brugia malayi	MH2 domain containing protein	0.0144	0.3171	0.3171
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0195	0.0135
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0084	0.0025
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0112	0.0112
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.2326	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0047	0.0831	0.0831
Schistosoma mansoni	survival motor neuron protein	0.005	0.0907	0.0907
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0947	0.0947
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0866	0.2985
Schistosoma mansoni	hypothetical protein	0.0035	0.0557	0.0557
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0047	0.0831	0.333
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0937	0.0937
Echinococcus granulosus	survival motor neuron protein 1	0.0244	0.5567	0.6892
Brugia malayi	chromobox protein homolog 3	0.004	0.0665	0.0665
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0095	0.1992	0.1944
Brugia malayi	Bloom's syndrome protein homolog	0.0029	0.0408	0.0408
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0195	0.2342
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0419	0.0419
Schistosoma mansoni	hypothetical protein	0.0016	0.0103	0.0103
Echinococcus granulosus	tumor protein p63	0.0349	0.8078	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0029	0.0408	0.1445
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0907	0.0907
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0798	0.0742
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0429	1	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0755	0.2992
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.2326	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1548	0.1916
Plasmodium falciparum	glutathione reductase	0.0017	0.0112	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0308	0.0308
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0103	0.0103
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0324	0.3741
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0103	0.0103
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0195	0.0135
Brugia malayi	hypothetical protein	0.0043	0.0755	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0831	0.0776
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0195	0.0135
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0112	0.0112
Echinococcus granulosus	chromobox protein 1	0.0071	0.1411	0.1747
Trypanosoma brucei	DNA polymerase IV, putative	0.0047	0.0831	0.0776
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.2342	0.8837
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0737	0.2912
Echinococcus multilocularis	chromobox protein 1	0.0071	0.1411	0.1747
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0866	0.0866
Leishmania major	diacylglycerol acyltransferase, putative	0.0429	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1548	0.1548
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0866	1
Brugia malayi	glutathione reductase	0.0048	0.0866	0.0866
Schistosoma mansoni	DNA polymerase IV / kappa	0.0014	0.006	0.006
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0095	0.1992	0.1992
Brugia malayi	TAR-binding protein	0.0076	0.1548	0.1548
Echinococcus multilocularis	tumor protein p63	0.0349	0.8078	1
Loa Loa (eye worm)	hypothetical protein	0.0244	0.5567	0.5567
Brugia malayi	polk-prov protein	0.0014	0.006	0.006
Echinococcus multilocularis	Immunoglobulin	0.0019	0.0162	0.02
Onchocerca volvulus		0.0051	0.0937	0.0501
Plasmodium falciparum	DNA repair protein REV1, putative	0.0014	0.006	0.0693
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.2326	0.8773
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0112	0.0053
Echinococcus multilocularis	bloom syndrome protein	0.0029	0.0408	0.0505
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0047	0.0831	0.1029
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3171	0.3171
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0304	0.7009	0.7009
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0419	0.5042
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0162	0.0162
Echinococcus granulosus	geminin	0.0205	0.4621	0.572
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0755	0.0935
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0429	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0947	0.0947
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1548	0.1548
Brugia malayi	Heterochromatin protein 1	0.0071	0.1411	0.1411
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0419	0.1492
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0047	0.0831	0.1029
Echinococcus granulosus	dna polymerase kappa	0.0047	0.0831	0.1029
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0419	0.1385
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0419	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.369	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.317	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.255	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.837	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.621	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.592	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.404	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.265	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.263	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.238	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1989898

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1646072