Detailed information for compound 1646109

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.931 | Formula: C24H24ClN5O5
  • H donors: 3 H acceptors: 5 LogP: 0.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccccc4c(c3Cn1c2=O)/C=N\NC(=O)C(N)C.Cl
  • InChi: 1S/C24H23N5O5.ClH/c1-3-24(33)17-8-19-20-15(10-29(19)22(31)16(17)11-34-23(24)32)14(9-26-28-21(30)12(2)25)13-6-4-5-7-18(13)27-20;/h4-9,12,33H,3,10-11,25H2,1-2H3,(H,28,30);1H/b26-9-;/t12?,24-;/m0./s1
  • InChiKey: STZLIGFSTBEMSS-NEEDQATFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0185 0.0145 0.0148
Trichomonas vaginalis esterase, putative 0.0042 0.0016 0.0035
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0047 0.0021 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0536 0.0463 0.0472
Trypanosoma brucei glucosidase, putative 0.012 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0074
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0081 0.0052 0.0053
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0045 0.0019 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.002 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0064 0.0065
Brugia malayi Prion-like- 0.0081 0.0052 0.0053
Echinococcus granulosus lysosomal alpha glucosidase 0.0541 0.0467 0.0476
Loa Loa (eye worm) hypothetical protein 0.0107 0.0075 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0045 0.0046
Echinococcus granulosus Immunoglobulin 0.0318 0.0266 0.027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0004 0.0004
Schistosoma mansoni cell adhesion molecule 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0074
Schistosoma mansoni nephrin related 0.0081 0.0052 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0541 0.0467 0.0476
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0024 0.0013
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0047 0.0021 0.001
Echinococcus granulosus peroxidasin 0.0185 0.0145 0.0148
Schistosoma mansoni titin 0.0185 0.0145 0.0148
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.0031 0.0032
Brugia malayi Immunoglobulin domain containing protein 0.0104 0.0072 0.0074
Echinococcus granulosus titin 0.0081 0.0052 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0016 0.0035
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 1.1095 1 1
Schistosoma mansoni cell adhesion molecule 0.0104 0.0072 0.0074
Schistosoma mansoni septate junction protein 0.0185 0.0145 0.0148
Echinococcus multilocularis titin 0.0081 0.0052 0.0053
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Leishmania major hypothetical protein, conserved 0.0029 0.0005 0.0005
Echinococcus multilocularis twitchin 0.0081 0.0052 0.0053
Echinococcus multilocularis titin 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.0073 0.0075
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Schistosoma mansoni septate junction protein 0.0104 0.0072 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 1.0895 0.982 1
Schistosoma mansoni alpha-glucosidase 0.0465 0.0399 0.0406
Echinococcus multilocularis Immunoglobulin 0.0318 0.0266 0.027
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 1.0895 0.982 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0046 0.002 0.0021
Trichomonas vaginalis maltase-glucoamylase, putative 0.012 0.0087 0.0187
Schistosoma mansoni microtubule-associated protein tau 0.153 0.136 0.1385
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0045 0.0019 0.0019
Echinococcus granulosus ornithine aminotransferase 0.0047 0.0021 0.0021
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 1.0895 0.982 1
Schistosoma mansoni alpha glucosidase 0.012 0.0087 0.0089
Echinococcus multilocularis Immunoglobulin 0.0318 0.0266 0.027
Trichomonas vaginalis alpha-glucosidase, putative 0.012 0.0087 0.0187
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0047 0.0021 0.0021
Echinococcus granulosus lachesin 0.0185 0.0145 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0024 0.0013
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0329 0.0276 0.027
Onchocerca volvulus 0.0313 0.0261 0.0266
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0185 0.0145 0.0148
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0104 0.0072 0.0074
Schistosoma mansoni intermediate filament proteins 0.0058 0.0031 0.0032
Loa Loa (eye worm) beta-lactamase 0.0042 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0045 0.0046
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0081 0.0052 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0019 0.0041
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 1.1095 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.012 0.0087 0.0089
Brugia malayi Glycosyl hydrolases family 31 protein 0.0045 0.0019 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0019 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.012 0.0087 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0045 0.0046
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0075 0.8651
Loa Loa (eye worm) projectin 0.0081 0.0052 0.0053
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0016 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0031 0.0032
Echinococcus multilocularis protein dispatched 1 0.0052 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0074
Echinococcus granulosus hemicentin 1 0.0185 0.0145 0.0148
Loa Loa (eye worm) one IG domain family member 0.0081 0.0052 0.0053
Echinococcus multilocularis netrin receptor unc 5 0.0104 0.0072 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0064 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0203 0.0207
Loa Loa (eye worm) dihydrofolate reductase 0.0522 0.045 0.0458
Brugia malayi kettin 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Echinococcus granulosus tyrosine protein kinase otk 0.0185 0.0145 0.0148
Onchocerca volvulus 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0064 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0016 0.0016
Echinococcus multilocularis roundabout 2 0.0185 0.0145 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Echinococcus granulosus lamin dm0 0.0058 0.0031 0.0032
Onchocerca volvulus 0.0081 0.0052 0.0053
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0019
Echinococcus granulosus titin 0.0081 0.0052 0.0053
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0329 0.0276 0.0592
Brugia malayi Fibronectin type III domain containing protein 0.0318 0.0266 0.027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Brugia malayi Prion-like- 0.0081 0.0052 0.0053
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0203 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0117 0.0119
Echinococcus granulosus netrin receptor unc 5 0.0104 0.0072 0.0074
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0016 0.0006
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0104 0.0072 0.0074
Echinococcus multilocularis lamin 0.0058 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Leishmania major glycosyl hydrolase-like protein 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0104 0.0072 0.0074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.012 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0502 0.0432 0.044
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.016 0.0123 0.0115
Onchocerca volvulus 0.0081 0.0052 0.0053
Loa Loa (eye worm) thymidylate synthase 1.0895 0.982 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0024 0.0013
Loa Loa (eye worm) LAD-2 short isoform 0.0104 0.0072 0.0074
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0185 0.0145 0.0148
Echinococcus granulosus lamin 0.0058 0.0031 0.0032
Onchocerca volvulus Putative titin 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0024 0.0013
Onchocerca volvulus 0.0081 0.0052 0.0053
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0045 0.0019 0.0019
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0185 0.0145 0.0148
Mycobacterium tuberculosis Hypothetical protein 0.5183 0.466 0.474
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0021 0.0021
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0185 0.0145 0.0148
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0074
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0047 0.0021 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0064 0.0065
Schistosoma mansoni nephrin 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.0502 0.0432 0.044
Schistosoma mansoni hemicentin 0.0081 0.0052 0.0053
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0943 0.0831 0.0846
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0104 0.0072 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0318 0.0266 0.027
Loa Loa (eye worm) TK protein kinase 0.0105 0.0073 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0016 0.0035
Brugia malayi Myb-like DNA-binding domain containing protein 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.0219 0.0213
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0012 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0103 0.0105
Plasmodium falciparum ornithine aminotransferase 0.0047 0.0021 0.0021
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0016 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Echinococcus granulosus down syndrome cell adhesion 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Conserved protein 0.0042 0.0016 0.0006
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0047 0.0021 0.001
Brugia malayi Prion-like- 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0072 0.0074
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0016 0.0017
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0329 0.0276 0.027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0007 0.0007
Echinococcus multilocularis Immunoglobulin 0.0104 0.0072 0.0074
Onchocerca volvulus 0.0042 0.0016 0.0017
Schistosoma mansoni septate junction protein 0.0185 0.0145 0.0148
Schistosoma mansoni hypothetical protein 0.0172 0.0134 0.0136
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0104 0.0072 0.0074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0046 0.002 0.0021
Trypanosoma brucei glycosyl hydrolase-like protein 0.0045 0.0019 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0075 0.0077
Chlamydia trachomatis dihydrofolate reductase 0.0522 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0074
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0522 0.045 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0052 0.0053
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0045 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Schistosoma mansoni neuroglian 0.0185 0.0145 0.0148
Schistosoma mansoni hypothetical protein 0.0038 0.0013 0.0013
Echinococcus granulosus leucine rich repeat containing protein 4 0.0081 0.0052 0.0053
Echinococcus granulosus titin 0.0081 0.0052 0.0053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin domain containing protein 0.0104 0.0072 0.0074
Echinococcus granulosus intermediate filament protein 0.0058 0.0031 0.0032
Schistosoma mansoni tyrosine kinase 0.0208 0.0167 0.017
Echinococcus multilocularis Immunoglobulin subtype 0.0104 0.0072 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Entamoeba histolytica hypothetical protein 0.0038 0.0013 0.1507
Schistosoma mansoni hypothetical protein 0.0172 0.0134 0.0136
Brugia malayi AMP-binding enzyme family protein 0.005 0.0024 0.0024
Schistosoma mansoni netrin receptor unc5 0.0104 0.0072 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0016 0.0017
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.5183 0.466 0.466
Onchocerca volvulus 1.0895 0.982 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Echinococcus granulosus roundabout 2 0.0185 0.0145 0.0148
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0024 0.2716
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Echinococcus multilocularis neutral alpha glucosidase AB 0.012 0.0087 0.0089
Schistosoma mansoni basigin related 0.0104 0.0072 0.0074
Schistosoma mansoni dihydrofolate reductase 0.0522 0.045 0.0458
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0045 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0012 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.5183 0.466 1
Trichomonas vaginalis alpha-glucosidase, putative 0.012 0.0087 0.0187
Onchocerca volvulus 0.0058 0.0031 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0016 0.0035
Brugia malayi thymidylate synthase 1.0895 0.982 1
Echinococcus granulosus defective proboscis extension response 0.0318 0.0266 0.027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0013
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0081 0.0052 0.0053
Echinococcus multilocularis insulin growth factor binding 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0024 0.0013
Echinococcus granulosus basement membrane specific heparan sulfate 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Echinococcus granulosus Aminotransferase class III 0.0047 0.0021 0.0021
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0104 0.0072 0.0074
Schistosoma mansoni roundabout 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0024 0.0013
Onchocerca volvulus 0.0081 0.0052 0.0053
Brugia malayi basement membrane proteoglycan precursor 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0013
Echinococcus granulosus roundabout 2 0.0185 0.0145 0.0148
Echinococcus multilocularis hemicentin 1 0.0185 0.0145 0.0148
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0104 0.0072 0.0074
Onchocerca volvulus 0.0028 0.0004 0.0004
Leishmania major alpha glucosidase II subunit, putative 0.012 0.0087 0.0087
Schistosoma mansoni cell adhesion molecule 0.0421 0.0359 0.0366
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Echinococcus multilocularis 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0016 0.0006
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0024 0.2716
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0016 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 1.1095 1 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Brugia malayi CHE-14 protein 0.0046 0.002 0.0021
Mycobacterium ulcerans hypothetical protein 0.0042 0.0016 0.0006
Brugia malayi TAR-binding protein 0.0073 0.0045 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0047 0.0021 0.0909
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0016 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0024 0.0013
Mycobacterium ulcerans hypothetical protein 0.005 0.0024 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Brugia malayi hypothetical protein 0.5183 0.466 0.4746
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0318 0.0266 0.027
Echinococcus multilocularis roundabout 2 0.0502 0.0432 0.044
Echinococcus granulosus titin 0.0081 0.0052 0.0053
Schistosoma mansoni vesicular amine transporter 0.0318 0.0266 0.027
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Echinococcus multilocularis lamin dm0 0.0058 0.0031 0.0032
Schistosoma mansoni lamin 0.0058 0.0031 0.0032
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0104 0.0072 0.0074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Giardia lamblia Kinase 0.0024 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0045 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0318 0.0266 0.027
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni lamin 0.0058 0.0031 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0016 0.0035
Onchocerca volvulus 0.4712 0.4235 0.4312
Echinococcus multilocularis roundabout 2 0.0185 0.0145 0.0148
Schistosoma mansoni peroxidasin 0.0104 0.0072 0.0074
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0081 0.0052 0.0053
Brugia malayi beta-lactamase family protein 0.0042 0.0016 0.0017
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0105 0.0073 0.0075
Echinococcus multilocularis Aminotransferase class III 0.0047 0.0021 0.0021
Onchocerca volvulus 0.0042 0.0016 0.0017
Mycobacterium ulcerans beta-lactamase 0.0042 0.0016 0.0006
Echinococcus multilocularis transfer RNA-Phe 0.0081 0.0052 0.0053
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0329 0.0276 0.027
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0024 0.2716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0064 0.0065
Brugia malayi beta-lactamase 0.0042 0.0016 0.0017
Echinococcus granulosus neutral alpha glucosidase AB 0.012 0.0087 0.0089
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0081 0.0052 0.0053
Brugia malayi AMP-binding enzyme family protein 0.005 0.0024 0.0024
Brugia malayi Immunoglobulin domain containing protein 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0013 0.0013
Brugia malayi Prion-like- 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0045 0.0019 0.2187
Echinococcus granulosus Immunoglobulin subtype 0.0104 0.0072 0.0074
Loa Loa (eye worm) TK/KIN16 protein kinase 0.5156 0.4636 0.4721
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0047 0.0021 0.001
Echinococcus multilocularis musashi 0.0058 0.0031 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0045 0.0046
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0047 0.0021 0.0197
Giardia lamblia Protein 21.1 0.0024 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Brugia malayi hypothetical protein 0.0038 0.0013 0.0013
Echinococcus granulosus expressed conserved protein 0.0101 0.0069 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.5156 0.4636 0.4721
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0021 0.0021
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0185 0.0145 0.0148
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) RNA binding protein 0.0073 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni netrin receptor unc5 0.0104 0.0072 0.0074
Brugia malayi hypothetical protein 0.0104 0.0072 0.0074
Echinococcus multilocularis neuroglian 0.0185 0.0145 0.0148
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0045 0.0046
Echinococcus granulosus Immunoglobulin 0.0104 0.0072 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0024 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0541 0.0467 0.0476
Giardia lamblia Kinase, NEK 0.0024 0 0.5
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.016 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0081 0.0052 0.0053
Schistosoma mansoni cell adhesion molecule 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0024 0.0013
Onchocerca volvulus 0.0081 0.0052 0.0053
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0021 0.001
Onchocerca volvulus 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0005
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0185 0.0145 0.0148
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0081 0.0052 0.0053
Echinococcus multilocularis lysosomal alpha glucosidase 0.0541 0.0467 0.0476
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0185 0.0145 0.0148
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0104 0.0072 0.0074
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0522 0.045 0.0448
Echinococcus multilocularis neuropeptide s receptor 0.0536 0.0463 0.0472
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0052 0.0053
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0081 0.0052 0.0053
Brugia malayi hypothetical protein 0.0318 0.0266 0.027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0024 0.0013
Mycobacterium ulcerans L-lysine aminotransferase 0.0047 0.0021 0.001
Echinococcus multilocularis peroxidasin 0.0185 0.0145 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.012 0.0087 0.0187
Loa Loa (eye worm) hypothetical protein 0.0318 0.0266 0.027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) TK/ROR protein kinase 0.0105 0.0073 0.0075
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0077 0.0078
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.012 0.0087 0.0187
Brugia malayi beta-lactamase family protein 0.0042 0.0016 0.0017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 1.1095 1 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0016 0.0006
Onchocerca volvulus 0.0042 0.0016 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0045 0.0046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0541 0.0467 0.0476
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0047 0.0021 0.001
Schistosoma mansoni alpha-glucosidase 0.0465 0.0399 0.0406
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0064 0.0065
Trichomonas vaginalis sucrase-isomaltase, putative 0.012 0.0087 0.0187
Schistosoma mansoni myosin-binding protein-related 0.0081 0.0052 0.0053
Echinococcus multilocularis protein patched 0.0046 0.002 0.0021
Plasmodium vivax ornithine aminotransferase, putative 0.0047 0.0021 0.0021
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0047 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0087 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.012 0.0087 0.0187
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0019
Echinococcus multilocularis geminin 0.0172 0.0134 0.0136
Brugia malayi Leucine Rich Repeat family protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0185 0.0145 0.0148
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0031 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0019 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0024 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0064 0.0065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0185 0.0145 0.0148
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0522 0.045 0.0448
Schistosoma mansoni hypothetical protein 0.0104 0.0072 0.0074
Echinococcus granulosus neuropeptide receptor A26 0.0536 0.0463 0.0472
Brugia malayi Disorganized muscle protein 1 0.0081 0.0052 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0013 0.0013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0045 0.0019 0.0041
Schistosoma mansoni nephrin 0.0399 0.0339 0.0345
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0016 0.0035
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.002 0.0021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Mycobacterium leprae Probable lipase LipE 0.0042 0.0016 0.0006
Onchocerca volvulus Tyrosine kinase homolog 0.4816 0.4329 0.4409
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.002 0.0021
Brugia malayi RNA binding protein 0.0073 0.0045 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.012 0.0087 0.0187
Onchocerca volvulus 0.0035 0.0011 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0016 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0016 0.0017
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0104 0.0072 0.0074
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0052 0.0053
Echinococcus granulosus geminin 0.0172 0.0134 0.0136
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0075 0.0077
Giardia lamblia Kinase, NEK 0.0024 0 0.5
Schistosoma mansoni cell adhesion molecule 0.0081 0.0052 0.0053
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0421 0.0359 0.0366
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0005 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0042 0.0016 0.0016
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.012 0.0087 0.0089
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni cell adhesion molecule 0.0081 0.0052 0.0053
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0031 0.0032
Mycobacterium tuberculosis Probable aminotransferase 0.0329 0.0276 0.027
Mycobacterium ulcerans thymidylate synthase 1.0895 0.982 1
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0104 0.0072 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0019 0.0041
Echinococcus granulosus tar DNA binding protein 0.0073 0.0045 0.0046
Echinococcus granulosus titin 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0185 0.0145 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0072 0.0074
Echinococcus multilocularis tyrosine protein kinase otk 0.0185 0.0145 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0185 0.0145 0.0148
Brugia malayi AMP-binding enzyme family protein 0.005 0.0024 0.0024
Schistosoma mansoni slit 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Schistosoma mansoni basigin related 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0005 0.0005
Onchocerca volvulus 0.0081 0.0052 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0016 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.012 0.0087 0.0187
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0005 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0005 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148
Schistosoma mansoni basigin related 0.0104 0.0072 0.0074
Echinococcus granulosus roundabout 2 0.0502 0.0432 0.044
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0104 0.0072 0.0074
Schistosoma mansoni cell adhesion molecule 0.0185 0.0145 0.0148
Brugia malayi intermediate filament protein 0.0058 0.0031 0.0032
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.016 0.0123 0.0115
Echinococcus multilocularis Immunoglobulin 0.0104 0.0072 0.0074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0013 0.0013
Toxoplasma gondii ABC1 family protein 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0421 0.0359 0.0366
Schistosoma mansoni cell adhesion molecule 0.0081 0.0052 0.0053
Echinococcus granulosus microtubule associated protein 2 0.153 0.136 0.1385
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0104 0.0072 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0017
Echinococcus granulosus neuroglian 0.0185 0.0145 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0072 0.0074
Brugia malayi basement membrane proteoglycan 0.0104 0.0072 0.0074
Echinococcus granulosus neuropeptide s receptor 0.0536 0.0463 0.0472
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0047 0.0021 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0087 0.0087
Mycobacterium ulcerans hypothetical protein 0.0329 0.0276 0.027
Onchocerca volvulus 0.0081 0.0052 0.0053
Echinococcus multilocularis hemicentin 1 0.0185 0.0145 0.0148
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0045 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0016 0.0006
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 1.1095 1 1
Echinococcus multilocularis dihydrofolate reductase 0.0522 0.045 0.0458
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.0072 0.0074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.012 0.0087 1
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Entamoeba histolytica hypothetical protein 0.0038 0.0013 0.1507
Echinococcus granulosus nephrin 0.0081 0.0052 0.0053
Echinococcus granulosus twitchin 0.0399 0.0339 0.0345
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0013
Entamoeba histolytica hypothetical protein 0.0038 0.0013 0.1507
Onchocerca volvulus 0.0081 0.0052 0.0053
Brugia malayi hypothetical protein 0.0029 0.0005 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0016 0.0017
Echinococcus multilocularis down syndrome cell adhesion 0.0081 0.0052 0.0053
Onchocerca volvulus 0.0081 0.0052 0.0053
Echinococcus multilocularis titin 0.0081 0.0052 0.0053
Brugia malayi Dihydrofolate reductase 0.0522 0.045 0.0458
Schistosoma mansoni cell adhesion molecule 0.0104 0.0072 0.0074
Brugia malayi dihydrofolate reductase family protein 0.0522 0.045 0.0458
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0318 0.0266 0.027
Brugia malayi Heparan sulfate 0.0104 0.0072 0.0074
Schistosoma mansoni septate junction protein 0.0104 0.0072 0.0074
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0075 0.0077
Echinococcus multilocularis titin 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0056 0.0029 0.003
Brugia malayi Peroxidasin 0.0185 0.0145 0.0148
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0117 0.0119
Brugia malayi MH2 domain containing protein 0.0138 0.0103 0.0105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Mycobacterium ulcerans lipase LipD 0.0042 0.0016 0.0006
Schistosoma mansoni titin 0.0081 0.0052 0.0053
Echinococcus granulosus thymidylate synthase 1.0895 0.982 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0047 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0042 0.0016 0.0006
Echinococcus multilocularis expressed conserved protein 0.0101 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0052 0.0053
Echinococcus granulosus contactin 0.0185 0.0145 0.0148
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0185 0.0145 0.0148
Schistosoma mansoni patched 1 0.0046 0.002 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0016 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0016 0.0006
Echinococcus multilocularis neuroglian 0.0399 0.0339 0.0345
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0024 0.0024
Onchocerca volvulus 0.005 0.0024 0.0024
Echinococcus granulosus neuroglian 0.0399 0.0339 0.0345
Echinococcus granulosus Immunoglobulin 0.0104 0.0072 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0005 0.0005
Brugia malayi protein unc-22 0.0081 0.0052 0.0053
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0047 0.0021 0.0011
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0104 0.0072 0.0074
Loa Loa (eye worm) CAMK protein kinase 0.0081 0.0052 0.0053
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0105 0.0073 0.0075
Entamoeba histolytica hypothetical protein 0.0038 0.0013 0.1507
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0019 0.0041
Schistosoma mansoni nephrin related 0.0104 0.0072 0.0074
Echinococcus multilocularis lachesin 0.0185 0.0145 0.0148
Onchocerca volvulus 0.0058 0.0031 0.0032
Onchocerca volvulus Netrin receptor homolog 0.0081 0.0052 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0103 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0064 0.0065
Echinococcus granulosus insulin growth factor binding 0.0081 0.0052 0.0053
Echinococcus granulosus low density lipoprotein receptor ldl 0.0104 0.0072 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0052 0.0053
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0081 0.0052 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.153 0.136 0.1385
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0019
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0104 0.0072 0.0074
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0081 0.0052 0.0053
Echinococcus granulosus dihydrofolate reductase 0.0522 0.045 0.0458
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0047 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0185 0.0145 0.0148
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.002 0.0021
Mycobacterium ulcerans acetylornithine aminotransferase 0.0047 0.0021 0.001
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0012 0.0012
Loa Loa (eye worm) disorganized muscle protein 1 0.0081 0.0052 0.0053
Echinococcus multilocularis thymidylate synthase 1.0895 0.982 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.003 0.0031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.0145 0.0148

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.934 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.67 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.666 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.553 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.397 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.748 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.739 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.624 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.873 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.786 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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