Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0158 | 0.4144 | 0.4144 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0299 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0299 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Echinococcus multilocularis | NMDA receptor | 0.0078 | 0.0836 | 0.0836 |
Schistosoma mansoni | nuclear hormone receptor | 0.0141 | 0.3442 | 0.3442 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0299 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0299 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0299 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0299 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0141 | 0.3442 | 0.3442 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0299 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0299 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0299 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0141 | 0.3442 | 0.3442 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0299 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0299 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0141 | 0.3442 | 0.3442 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0158 | 0.4144 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0141 | 0.3442 | 0.3442 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0299 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0299 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0299 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0299 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0078 | 0.0836 | 0.0836 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0158 | 0.4144 | 0.4144 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0299 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0158 | 0.4144 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0299 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0141 | 0.3442 | 0.3442 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0299 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0299 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0078 | 0.0836 | 0.0836 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0141 | 0.3442 | 0.3442 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0299 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0299 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0299 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0141 | 0.3442 | 0.3442 |
Schistosoma mansoni | glutamate receptor kainate | 0.0109 | 0.2114 | 0.2114 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0158 | 0.4144 | 0.4144 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0141 | 0.3442 | 0.3442 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0141 | 0.3442 | 0.3442 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0299 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0158 | 0.4144 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0299 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0078 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0299 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0141 | 0.3442 | 0.3442 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0299 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0299 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0299 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0141 | 0.3442 | 0.3442 |
Schistosoma mansoni | zinc finger protein | 0.0141 | 0.3442 | 0.3442 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0158 | 0.4144 | 0.1071 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0078 | 0.0836 | 0.0836 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0118 | 0.2498 | 0.2498 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0141 | 0.3442 | 0.3442 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0141 | 0.3442 | 0.3442 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0299 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0299 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0299 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0299 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0109 | 0.2114 | 0.2114 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0158 | 0.4144 | 0.4144 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4144 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0299 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.573 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.465 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.316 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.268 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.25 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.2 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.165 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.055 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.