Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 0.2124 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3996 | 0.5699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Onchocerca volvulus | 0.0109 | 0.0125 | 0.0993 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.0125 | 0.0125 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1556 | 0.2199 | 0.2124 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3996 | 0.5699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.0125 | 0.0993 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1556 | 0.2199 | 0.2199 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3996 | 0.5699 | 1 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Echinococcus granulosus | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.0125 | 0.0125 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0267 | 0.0351 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.0125 | 0.0125 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.0125 | 0.0993 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.0125 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Loa Loa (eye worm) | hypothetical protein | 0.6994 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1556 | 0.2199 | 0.2199 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -0.33 | Binding affinity towards benzodiazepine receptor inverse agonist site by the displacement of [3H]-Diazepam in rat cerebral cortical membranes. | ChEMBL. | 8411009 |
Log 1/IC50 (binding) | = -0.33 | Binding affinity towards benzodiazepine receptor inverse agonist site by the displacement of [3H]-Diazepam in rat cerebral cortical membranes. | ChEMBL. | 8411009 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.