Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0184 | 0.0627 |
Brugia malayi | hypothetical protein | 0.011 | 0.0229 | 0.0779 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.0018 | 0.0063 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1582 | 0.4515 | 1 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Leishmania major | pteridine reductase 1 | 0.0197 | 0.0482 | 0.0595 |
Echinococcus multilocularis | thymidylate synthase | 0.1039 | 0.2933 | 0.2933 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.011 | 0.0227 | 0.0774 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.0018 | 0.0063 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.0018 | 0.0063 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0018 | 0.0063 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0737 | 0.2053 | 0.2053 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.0089 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0228 | 0.0572 | 0.0572 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1582 | 0.4515 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0973 | 0.2741 | 0.2741 |
Trypanosoma brucei | pteridine reductase 1 | 0.0195 | 0.0475 | 0.0577 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | thymidylate synthase | 0.1039 | 0.2933 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1347 | 1 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.011 | 0.0227 | 0.0774 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0494 | 0.1347 | 0.4326 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0184 | 0.0627 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0089 | 0.0304 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1039 | 0.2933 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0241 | 0.0821 |
Echinococcus multilocularis | geminin | 0.0114 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0227 | 0.0774 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1582 | 0.4515 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0033 | 0.0004 | 0.0012 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0737 | 0.2053 | 0.6852 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0737 | 0.2053 | 0.6852 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0737 | 0.2053 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1039 | 0.2933 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0184 | 0.0627 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.0089 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.3465 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0018 | 0.0063 |
Echinococcus multilocularis | tumor protein p63 | 0.0228 | 0.0572 | 0.0572 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0973 | 0.2741 | 0.2741 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.0041 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0018 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0146 | 0.0499 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.0257 | 0.0876 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0005 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0018 | 0.0063 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0737 | 0.2053 | 0.7001 |
Brugia malayi | MH2 domain containing protein | 0.0206 | 0.0509 | 0.1734 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.0041 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0146 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0942 | 0.2652 | 0.9042 |
Onchocerca volvulus | 0.0033 | 0.0003 | 0.001 | |
Brugia malayi | PAS domain containing protein | 0.0033 | 0.0004 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0018 | 0.0063 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0089 | 0.0304 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0062 | 0.0089 | 0.0089 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0062 | 0.0089 | 0.0304 |
Brugia malayi | hypothetical protein | 0.0494 | 0.1347 | 0.4593 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | Dihydrofolate reductase | 0.0737 | 0.2053 | 0.7001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0184 | 0.0627 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0206 | 0.0509 | 0.1734 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Echinococcus granulosus | thymidylate synthase | 0.1039 | 0.2933 | 0.2933 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.0146 | 0.0499 |
Schistosoma mansoni | dihydrofolate reductase | 0.0737 | 0.2053 | 0.7001 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.1039 | 0.2933 | 1 | |
Onchocerca volvulus | 0.0033 | 0.0005 | 0.0018 | |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0241 | 0.0821 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0159 | 0.0373 | 0.0373 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.0089 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0737 | 0.2053 | 0.6852 |
Brugia malayi | dihydrofolate reductase family protein | 0.0737 | 0.2053 | 0.7001 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0973 | 0.2741 | 0.9345 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | single-minded | 0.0033 | 0.0004 | 0.0012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.0257 | 0.0876 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | survival motor neuron protein | 0.0033 | 0.0003 | 0.001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0184 | 0.0184 |
Mycobacterium ulcerans | thymidylate synthase | 0.1039 | 0.2933 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.0227 | 0.0735 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1582 | 0.4515 | 1 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0257 | 0.0876 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.2422 | 0.8258 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1582 | 0.4515 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0229 | 0.0779 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0184 | 0.0184 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Echinococcus granulosus | geminin | 0.0114 | 0.0241 | 0.0241 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.011 | 0.0227 | 0.0227 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0018 | 0.0018 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0033 | 0.0005 | 0.0018 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0206 | 0.0509 | 0.1734 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0494 | 0.1347 | 0.2612 |
Brugia malayi | hypoxia-induced factor 1 | 0.0102 | 0.0204 | 0.0695 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0062 | 0.0089 | 0.0089 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.011 | 0.0227 | 0.0774 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0184 | 0.0627 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.0018 | 0.0018 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0184 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0003 | 0.001 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0033 | 0.0003 | 0.001 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0018 | 0.0018 |
Echinococcus granulosus | dihydrofolate reductase | 0.0737 | 0.2053 | 0.2053 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1039 | 0.2933 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.0257 | 0.0876 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | thymidylate synthase | 0.1039 | 0.2933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0373 | 0.127 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1582 | 0.4515 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0159 | 0.0373 | 0.0373 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0184 | 0.0184 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.011 | 0.0227 | 0.0227 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Brugia malayi | hypothetical protein | 0.0159 | 0.0373 | 0.127 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.011 | 0.0227 | 0.0735 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0102 | 0.0204 | 0.0695 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -7.433 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.654 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.534 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.508 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.472 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.466 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.384 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.234 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.645 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.