Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0044 | 0.1585 | 0.2064 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0056 | 0.2326 | 0.481 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0056 | 0.2326 | 0.481 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3546 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0044 | 0.1585 | 0.2064 |
Loa Loa (eye worm) | fatty acid synthase | 0.0052 | 0.2082 | 0.1773 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0053 | 0.2125 | 0.4065 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3546 | 0.2019 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0038 | 0.1213 | 0.3255 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0079 | 0.3727 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.2125 | 0.4065 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3546 | 0.2019 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0043 | 0.1492 | 0.172 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0053 | 0.2125 | 0.5702 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0052 | 0.2026 | 0.5436 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.2326 | 0.481 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0056 | 0.2326 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0079 | 0.3727 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3546 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0053 | 0.2125 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0701 | 0.0338 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.7897 | 0.74 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0052 | 0.2026 | 0.5436 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0053 | 0.2125 | 0.4065 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0056 | 0.2326 | 0.6242 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0044 | 0.1585 | 0.4254 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0043 | 0.1492 | 0.172 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.2125 | 0.4065 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.005 | 0.1912 | 0.5131 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.003 | 0.0728 | 0.1953 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3546 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0079 | 0.3727 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3546 | 0.2019 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0079 | 0.3727 | 1 |
Onchocerca volvulus | 0.0093 | 0.4523 | 0.3228 | |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.7897 | 0.74 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3546 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0053 | 0.2125 | 0.0263 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0056 | 0.2326 | 0.481 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0053 | 0.2125 | 0.4065 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0043 | 0.1492 | 0.172 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0034 | 0.0987 | 0.2574 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3546 | 0.3293 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3546 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0038 | 0.1192 | 0.3708 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3546 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0053 | 0.2125 | 0.4065 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0053 | 0.2125 | 0.5702 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3546 | 0.3293 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.2326 | 0.6242 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0022 | 0.0196 | 0.0527 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.2326 | 0.481 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3546 | 0.3293 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0056 | 0.2326 | 0.6242 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3546 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.7897 | 0.7815 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0101 | 0.5025 | 0.3848 |
Brugia malayi | hypothetical protein | 0.0148 | 0.7897 | 0.74 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.7897 | 0.7815 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0096 | 0.4724 | 0.3477 |
Mycobacterium ulcerans | thioesterase | 0.0044 | 0.1585 | 0.2064 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.2326 | 0.481 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0053 | 0.2125 | 0.5702 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.4327 | 0.4105 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0043 | 0.1535 | 0.4119 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.005 | 0.1912 | 0.1596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.