Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0086 | 0.2709 | 0.6337 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0564 | 0.0427 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0081 | 0.2513 | 0.2513 |
Mycobacterium ulcerans | polyketide synthase | 0.0086 | 0.2709 | 0.6522 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0054 | 0.1441 | 0.2941 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0564 | 0.2043 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0086 | 0.2709 | 0.6522 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0564 | 0.0427 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2202 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0065 | 0.1894 | 0.4452 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.2202 | 0.2202 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0302 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.008 | 0.247 | 0.247 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0302 | 0.0455 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0121 | 0.4077 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0081 | 0.2513 | 0.6044 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.2202 | 0.2202 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.002 | 0.0143 | 0.0143 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.2202 | 0.2202 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0146 | 0.5051 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1522 | 0.6694 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0564 | 0.0427 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0273 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0302 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0068 | 0.1985 | 0.4398 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.002 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.2202 | 0.2202 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0058 | 0.1622 | 0.3791 |
Brugia malayi | AMP-binding enzyme family protein | 0.0076 | 0.2305 | 0.2305 |
Mycobacterium ulcerans | thioesterase | 0.0068 | 0.1985 | 0.4682 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0081 | 0.2513 | 0.6044 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0086 | 0.2709 | 0.6541 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0079 | 0.2416 | 0.5799 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0033 | 0.0628 | 0.128 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0025 | 0.0322 | 0.0505 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2202 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.2202 | 0.2089 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.2202 | 0.2089 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0081 | 0.2513 | 0.6023 |
Brugia malayi | RNA binding protein | 0.0073 | 0.2202 | 0.2202 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0046 | 0.1148 | 0.2593 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0053 | 0.1401 | 0.4903 |
Mycobacterium ulcerans | polyketide synthase | 0.0081 | 0.2513 | 0.6023 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0025 | 0.0343 | 0.0558 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0564 | 0.0427 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.2513 | 0.6023 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0065 | 0.1894 | 0.4452 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0086 | 0.2709 | 0.6337 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0564 | 0.0427 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0066 | 0.1936 | 0.4587 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.2202 | 0.2202 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0079 | 0.2416 | 0.5799 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0542 | 0.0542 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0065 | 0.1894 | 0.4155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.2513 | 0.6023 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2202 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0086 | 0.2709 | 0.6541 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.1522 | 0.6694 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.2043 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.002 | 0.0143 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0081 | 0.2513 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0028 | 0.0437 | 0.0795 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0121 | 0.4077 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2202 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0068 | 0.1985 | 0.4682 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0058 | 0.1601 | 0.5682 |
Schistosoma mansoni | methyltransferase-related | 0.0024 | 0.0302 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1122 | 0.1122 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0024 | 0.0302 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0086 | 0.2709 | 0.6541 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.002 | 0.0143 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0076 | 0.2305 | 0.5519 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0025 | 0.0322 | 0.0454 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0041 | 0.0948 | 0.3136 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.002 | 0.0143 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0068 | 0.1985 | 0.4711 |
Onchocerca volvulus | 0.0141 | 0.4855 | 0.9562 | |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0121 | 0.4077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4663 | 0.4663 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0154 | 0.5345 | 0.5345 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0121 | 0.4077 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0081 | 0.2513 | 0.6044 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0081 | 0.2513 | 0.581 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.002 | 0.0143 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0054 | 0.1441 | 0.3299 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.002 | 0.0143 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.002 | 0.0143 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0025 | 0.0343 | 0.0508 |
Giardia lamblia | Methyltransferase like 2 | 0.0024 | 0.0302 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.2043 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0024 | 0.0302 | 0.0302 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0054 | 0.1441 | 0.3299 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.002 | 0.0143 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0086 | 0.2709 | 0.6522 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.1522 | 0.1522 |
Onchocerca volvulus | 0.0056 | 0.1522 | 0.2134 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0086 | 0.2709 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0081 | 0.2513 | 0.6023 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0076 | 0.2305 | 0.2305 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.2202 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0086 | 0.2709 | 1 |
Onchocerca volvulus | 0.0076 | 0.2305 | 0.3879 | |
Loa Loa (eye worm) | acyl carrier protein | 0.0037 | 0.0804 | 0.0804 |
Echinococcus granulosus | lamin | 0.0031 | 0.0564 | 0.0427 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0273 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.185 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.