Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0444 | 0.1356 | 0.0308 |
Echinococcus multilocularis | FTZ F1 alpha | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Onchocerca volvulus | Bile acid receptor homolog | 0.084 | 0.3644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.194 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0444 | 0.1356 | 0.0308 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0444 | 0.1356 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.194 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | steroid hormone receptor | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.084 | 0.3644 | 0.2874 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.194 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | steroid hormone receptor | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | nuclear receptor NHR-88 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0444 | 0.1356 | 0.0308 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | coup transcription factor | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.194 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.1832 | 0.9377 | 0.9301 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | nuclear hormone receptor | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.084 | 0.3644 | 0.2874 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0786 | 0.3334 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.194 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.084 | 0.3644 | 0.2874 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.084 | 0.3644 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | FTZ F1 alpha | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | nuclear hormone receptor | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | thyroid hormone receptor | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.194 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.1832 | 0.9377 | 0.9301 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.194 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.084 | 0.3644 | 0.2874 |
Onchocerca volvulus | 0.084 | 0.3644 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0209 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0444 | 0.1356 | 0.0308 |
Schistosoma mansoni | thyroid hormone receptor | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0444 | 0.1356 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.084 | 0.3644 | 0.2874 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.194 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0444 | 0.1356 | 0.0308 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.084 | 0.3644 | 0.2874 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | nuclear receptor RXR | 0.0444 | 0.1356 | 0.0308 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.084 | 0.3644 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.084 | 0.3644 | 0.2874 |
Brugia malayi | hypothetical protein | 0.0444 | 0.1356 | 0.0308 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.084 | 0.3644 | 0.2874 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.084 | 0.3644 | 0.2874 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.084 | 0.3644 | 0.2874 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.084 | 0.3644 | 0.2874 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.834 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.679 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.679 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.643 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.592 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.587 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.283 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.