Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0604 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.1305 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.3088 | 0.4583 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.1305 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.1941 | 0.1941 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0044 | 0.1305 | 0.1305 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.3088 | 0.4583 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1305 | 0.1305 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.1941 | 0.1941 |
Brugia malayi | hypothetical protein | 0.002 | 0.0022 | 0.0032 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.3088 | 0.3088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.1941 | 0.1941 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0031 | 0.0604 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.3088 | 0.4583 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.1941 | 0.1941 |
Brugia malayi | RNA binding protein | 0.0077 | 0.3088 | 0.4583 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.3088 | 0.3088 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0056 | 0.1941 | 0.2881 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3088 | 0.3088 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.1305 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0031 | 0.0604 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0604 | 0.0896 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0145 | 0.6739 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0604 | 0.0896 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0031 | 0.0604 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0031 | 0.0604 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0206 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.1941 | 0.1941 |
Brugia malayi | hypothetical protein | 0.0044 | 0.1305 | 0.1937 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.3088 | 0.4583 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0056 | 0.1941 | 0.2881 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.3088 | 0.4583 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0044 | 0.1305 | 0.1305 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.1941 | 0.1941 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0031 | 0.0604 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0031 | 0.0604 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.1305 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3088 | 0.3088 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0031 | 0.0604 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0044 | 0.1305 | 0.1305 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.1941 | 0.1941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3088 | 0.3088 |
Brugia malayi | MH2 domain containing protein | 0.0145 | 0.6739 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3088 | 0.3088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0145 | 0.6739 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.