Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.4916 | 0.4916 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.6848 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.6848 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.6848 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.6848 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.6848 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.6848 | 0.6848 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.6848 | 0.6848 |
Onchocerca volvulus | 0.0011 | 0.6848 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.6848 | 1 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.6848 | 0.6848 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.6848 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.6848 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.6848 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.6848 | 0.6848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DNA cleavage (functional) | = 0.3 ug ml-1 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | ChEMBL. | 2002456 |
DNA cleavage (functional) | = 0.3 ug ml-1 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | ChEMBL. | 2002456 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | ChEMBL. | 2002456 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus (UC76) | ChEMBL. | 2002456 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | ChEMBL. | 2002456 |
MIC (functional) | = 0.025 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus (H228) | ChEMBL. | 2002456 |
MIC (functional) | = 0.025 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pneumoniae (SV-1) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity against gram negative organism, Escherichia cloacae (MA2646) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram negative organism, K. pneumonia(MGH-2) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. rettgeri. (M1771) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. faecalis (MGH-2) | ChEMBL. | 2002456 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pyogenes (C203) | ChEMBL. | 2002456 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. aeruginosa (UI-18) | ChEMBL. | 2002456 |
Ratio (functional) | = 0.029 | MIC ratio measured as the mean MICs of gram-positive bacteria | ChEMBL. | 2002456 |
Ratio (functional) | = 0.05 | MIC ratio measured as the mean MICs of gram-negative bacteria | ChEMBL. | 2002456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.