Detailed information for compound 164711

Basic information

Technical information
  • TDR Targets ID: 164711
  • Name: 1-(1,3-benzodioxol-5-yl)-4-(4-benzylpiperazin -1-yl)cyclohexan-1-ol
  • MW: 394.507 | Formula: C24H30N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1(CCC(CC1)N1CCN(CC1)Cc1ccccc1)c1ccc2c(c1)OCO2
  • InChi: 1S/C24H30N2O3/c27-24(20-6-7-22-23(16-20)29-18-28-22)10-8-21(9-11-24)26-14-12-25(13-15-26)17-19-4-2-1-3-5-19/h1-7,16,21,27H,8-15,17-18H2
  • InChiKey: QWOWPFGONZKUAH-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(1,3-benzodioxol-5-yl)-4-(4-benzylpiperazin-1-yl)cyclohexanol
  • 1-(1,3-benzodioxol-5-yl)-4-(4-benzyl-1-piperazinyl)cyclohexanol
  • 1-(1,3-benzodioxol-5-yl)-4-[4-(phenylmethyl)piperazin-1-yl]cyclohexan-1-ol
  • 1-(1,3-benzodioxol-5-yl)-4-(4-benzylpiperazino)cyclohexanol
  • 1-(1,3-benzodioxol-5-yl)-4-[4-(phenylmethyl)-1-piperazinyl]-1-cyclohexanol
  • 1-(1,3-benzodioxol-5-yl)-4-[4-(benzyl)piperazin-1-yl]cyclohexan-1-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Rattus norvegicus Serotonin 2 (5-HT2) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 332 aa 21.7 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Brugia malayi sulfakinin receptor protein Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 23.3 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Brugia malayi GnHR receptor homolog Serotonin 1b (5-HT1b) receptor   386 aa 335 aa 21.8 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 30.8 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1b (5-HT1b) receptor   386 aa 310 aa 21.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Onchocerca volvulus Forkhead box protein biniou homolog Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.3 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1b (5-HT1b) receptor   386 aa 371 aa 26.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus multilocularis serotonin receptor Serotonin 1b (5-HT1b) receptor   386 aa 393 aa 32.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus multilocularis neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.4 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 1b (5-HT1b) receptor   386 aa 350 aa 18.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Echinococcus granulosus neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.8 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 334 aa 24.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 363 aa 34.4 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 33.4 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 354 aa 20.1 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 1b (5-HT1b) receptor   386 aa 359 aa 22.0 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0048 0.0332 0.0568
Echinococcus granulosus Niemann Pick C1 protein 0.0094 0.095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0149 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Brugia malayi TATA binding protein associated factor 0.0025 0.0025 0.0034
Brugia malayi CHE-14 protein 0.004 0.0236 0.0312
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0028 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0584 0.189
Echinococcus multilocularis serotonin receptor 0.0181 0.2106 0.2086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0149 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Plasmodium vivax endoplasmin, putative 0.0031 0.0112 1
Onchocerca volvulus 0.0034 0.0149 0.0805
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0112 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0028 0.0003
Brugia malayi neuropeptide F receptor 0.0034 0.0149 0.0198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0156 0.0131
Entamoeba histolytica hypothetical protein 0.0034 0.0156 0.1641
Brugia malayi hypothetical protein 0.0025 0.0025 0.0034
Echinococcus multilocularis microtubule associated protein 2 0.0659 0.8465 0.8461
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0149 0.0146
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0025 0.1612
Schistosoma mansoni neuropeptide receptor 0.0034 0.0149 0.0146
Brugia malayi Endoplasmin precursor 0.0031 0.0112 0.0148
Schistosoma mansoni patched 1 0.004 0.0236 0.0249
Loa Loa (eye worm) hypothetical protein 0.0084 0.0818 0.1399
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Schistosoma mansoni hypothetical protein 0.0033 0.0132 0.0126
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0025 0.0034
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Loa Loa (eye worm) hypothetical protein 0.0391 0.4901 0.8382
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0149 0.0146
Echinococcus multilocularis expressed conserved protein 0.0088 0.0874 0.085
Schistosoma mansoni amine GPCR 0.0034 0.0149 0.0146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.005 0.0083
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0149 0.0146
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Onchocerca volvulus 0.0034 0.0149 0.0805
Schistosoma mansoni eyes absent homolog 0.0084 0.0818 0.0939
Trypanosoma brucei glucosidase, putative 0.0035 0.0158 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1769 0.1747
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Schistosoma mansoni biogenic amine receptor 0.0034 0.0149 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0149 0.0146
Brugia malayi RE15519p 0.0034 0.0149 0.0198
Brugia malayi Niemann-Pick C1 protein precursor 0.0094 0.095 0.1259
Schistosoma mansoni opsin-like receptor 0.0034 0.0149 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0112 0.0292
Schistosoma mansoni heat shock protein 0.0031 0.0112 0.0102
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0149 0.0146
Echinococcus multilocularis heat shock protein 90 0.0025 0.0028 0.0002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0158 0.0449
Brugia malayi hypothetical protein 0.0084 0.0818 0.1085
Brugia malayi larval opioid receptor 0.0034 0.0149 0.0198
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0149 0.0146
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0158 0.0449
Schistosoma mansoni opsin-like receptor 0.0034 0.0149 0.0146
Onchocerca volvulus 0.0034 0.0149 0.0805
Loa Loa (eye worm) serotonin transporter b 0.0073 0.067 0.1146
Echinococcus granulosus heat shock protein 90 0.0025 0.0028 0.0003
Echinococcus granulosus tar DNA binding protein 0.006 0.0504 0.0566
Onchocerca volvulus 0.0073 0.067 0.3619
Echinococcus multilocularis protein patched 0.004 0.0236 0.0211
Schistosoma mansoni tar DNA-binding protein 0.006 0.0504 0.0566
Plasmodium falciparum heat shock protein 90 0.0031 0.0112 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0149 0.0146
Schistosoma mansoni adenoreceptor 0.0034 0.0149 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0332 0.044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.067 0.0889
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0149 0.0805
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis serotonin receptor 0.0181 0.2106 0.2086
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0095 0.0969 0.1118
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0149 0.0124
Echinococcus granulosus geminin 0.0162 0.1851 0.2164
Onchocerca volvulus 0.0034 0.0149 0.0805
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0149 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1967 0.6573
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1769 0.1747
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus chromobox protein 1 0.0067 0.0584 0.0662
Loa Loa (eye worm) hypothetical protein 0.0143 0.1596 0.273
Onchocerca volvulus 0.0034 0.0149 0.0805
Schistosoma mansoni biogenic amine (5HT) receptor 0.0181 0.2106 0.2465
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0028 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0025 0.9223
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0149 0.0255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0332 0.044
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0149 0.0124
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0112 0.0191
Echinococcus granulosus g protein coupled receptor 0.0034 0.0149 0.0146
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0149 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0073 0.067 0.1146
Brugia malayi heat shock protein 90 0.0031 0.0112 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.028 0.0301
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 1
Echinococcus multilocularis geminin 0.0162 0.1851 0.1831
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0149 0.0146
Brugia malayi Heterochromatin protein 1 0.0067 0.0584 0.0774
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis chromobox protein 1 0.0067 0.0584 0.056
Onchocerca volvulus 0.009 0.0896 0.4839
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0149 0.0146
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0233 0.1256
Echinococcus multilocularis muscleblind protein 1 0.0143 0.1596 0.1575
Schistosoma mansoni hypothetical protein 0.0039 0.0216 0.0226
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0149 0.0124
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0084 0.0818 0.1399
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0149 0.0255
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0149 0.0255
Onchocerca volvulus 0.0034 0.0149 0.0805
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.067 1
Echinococcus granulosus muscleblind protein 0.0143 0.1596 0.1861
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis serotonin transporter 0.0073 0.067 0.0646
Trichomonas vaginalis chromobox protein, putative 0.004 0.0233 0.0701
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0156 0.1769 0.3024
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0149 0.0146
Trichomonas vaginalis chromobox protein, putative 0.004 0.0233 0.0701
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0149 0.0255
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0149 0.0146
Brugia malayi RNA binding protein 0.006 0.0504 0.0668
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0112 0.6503
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0025 0.0268
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Schistosoma mansoni chromobox protein 0.0067 0.0584 0.0662
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0112 0.6503
Echinococcus granulosus g protein coupled receptor 0.0034 0.0149 0.0146
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0149 0.0255
Onchocerca volvulus 0.0034 0.0149 0.0805
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0112 0.1177
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0112 0.6503
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0149 0.0146
Echinococcus multilocularis Niemann Pick C1 protein 0.0134 0.1486 0.1464
Echinococcus multilocularis muscleblind protein 0.0143 0.1596 0.1575
Brugia malayi G protein-coupled receptor 0.0034 0.0149 0.0198
Brugia malayi G-protein coupled receptor 0.0034 0.0149 0.0198
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Schistosoma mansoni tar DNA-binding protein 0.006 0.0504 0.0566
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Brugia malayi hypothetical protein 0.0034 0.0156 0.0207
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0158 0.021
Brugia malayi Glycosyl hydrolases family 31 protein 0.0156 0.1769 0.2345
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0149 0.0124
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0195 0.1053
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0149 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Schistosoma mansoni hypothetical protein 0.0039 0.0216 0.0226
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0158 0.1665
Loa Loa (eye worm) RNA binding protein 0.006 0.0504 0.0861
Brugia malayi chromobox protein homolog 3 0.0037 0.0195 0.0259
Echinococcus granulosus leukotriene A 4 hydrolase 0.0462 0.5847 0.6898
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0154
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0149 0.0146
Echinococcus granulosus allatostatin A receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0181 0.2106 0.3601
Onchocerca volvulus Glucosylceramidase homolog 0.0162 0.1851 1
Echinococcus granulosus neuropeptide receptor 0.0034 0.0149 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0149 0.0146
Schistosoma mansoni endoplasmin 0.0031 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0073 0.067 0.1146
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0584 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0158 0.1665
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.067 0.0764
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0149 0.0198
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0149 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0149 0.0146
Schistosoma mansoni biogenic amine receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0049 0.0356 0.0609
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0149 0.0146
Onchocerca volvulus 0.0025 0.0025 0.0138
Brugia malayi neuropeptide F receptor 0.0034 0.0149 0.0198
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0149 0.0146
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0112 0.6503
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0332 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Schistosoma mansoni alpha-glucosidase 0.0134 0.148 0.1724
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0028 0.0162
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Onchocerca volvulus 0.0025 0.0025 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0149 0.0146
Brugia malayi hypothetical protein 0.0212 0.2526 0.3349
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.067 0.1146
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0162 0.1851 0.2164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus Niemann Pick C1 protein 0.0134 0.1486 0.1731
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0195 0.0574
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0149 0.0124
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0094 0.095 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0195 0.0574
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0158 0.0449
Schistosoma mansoni hypothetical protein 0.0162 0.1851 0.2164
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0158 0.0449
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Schistosoma mansoni opsin-like receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0149 0.0255
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0149 0.0124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0504 0.0861
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0462 0.5847 0.6898
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0158 0.0449
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.028 0.0371
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0132 0.0175
Echinococcus granulosus lysosomal alpha glucosidase 0.0156 0.1769 0.2065
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0584 0.189
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0149 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Echinococcus granulosus serotonin receptor 0.0034 0.0149 0.0146
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0149 0.0198
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0149 0.0124
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.5993 0.7071
Echinococcus granulosus expressed conserved protein 0.0088 0.0874 0.1005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0195 0.0333
Schistosoma mansoni hypothetical protein 0.0039 0.0216 0.0226
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Brugia malayi ORL1-like opioid receptor 0.0034 0.0149 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.028 0.0301
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus chromobox protein 1 0.0067 0.0584 0.0662
Echinococcus granulosus fmrfamide receptor 0.0034 0.0149 0.0146
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0149 0.0146
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0025 0.0044
Onchocerca volvulus 0.0034 0.0149 0.0805
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0149 0.0146
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0025 0.9223
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0044
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0149 0.0124
Brugia malayi AKH receptor 0.0034 0.0149 0.0198
Onchocerca volvulus 0.0029 0.0088 0.0474
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0247 0.298 0.5095
Onchocerca volvulus 0.0025 0.0025 0.0138
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Schistosoma mansoni amine GPCR 0.0034 0.0149 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1967 0.6573
Onchocerca volvulus 0.0034 0.0149 0.0805
Schistosoma mansoni amine GPCR 0.0034 0.0149 0.0146
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0391 0.4901 0.6499
Echinococcus granulosus neuropeptide receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis sex peptide receptor 0.0034 0.0149 0.0124
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0158 0.0157
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0025 0.1612
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0149 0.0124
Onchocerca volvulus 0.0034 0.0149 0.0805
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0149 0.0805
Echinococcus granulosus neuropeptide s receptor 0.0473 0.5993 0.7071
Schistosoma mansoni tar DNA-binding protein 0.006 0.0504 0.0566
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0149 0.0124
Schistosoma mansoni hypothetical protein 0.0039 0.0216 0.0226
Echinococcus granulosus endoplasmin 0.0025 0.0028 0.0003
Schistosoma mansoni tar DNA-binding protein 0.006 0.0504 0.0566
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Echinococcus multilocularis tar DNA binding protein 0.006 0.0504 0.0479
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0028 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0462 0.5847 1
Schistosoma mansoni neuropeptide receptor 0.0034 0.0149 0.0146
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0149 0.0198
Brugia malayi Serotonin receptor 0.0589 0.7541 1
Brugia malayi G-protein coupled receptor 0.0034 0.0149 0.0198
Onchocerca volvulus 0.0034 0.0149 0.0805
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0149 0.0124
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0158 0.0449
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Echinococcus granulosus hypothetical protein 0.0034 0.0149 0.0146
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0025 0.0034
Brugia malayi Dopamine receptor protein 1 0.0034 0.0149 0.0198
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0028 1
Schistosoma mansoni chromobox protein 0.0067 0.0584 0.0662
Onchocerca volvulus 0.0034 0.0149 0.0805
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0025 0.1612
Schistosoma mansoni histamine h1 receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0149 0.0124
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0149 0.0124
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0149 0.0198
Onchocerca volvulus 0.0034 0.0149 0.0805
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.067 0.0764
Echinococcus granulosus Protein patched homolog 1 0.004 0.0236 0.0249
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0028 0.0162
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.0149 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0149 0.0146
Schistosoma mansoni myosin xvIII 0.0034 0.0149 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.5993 0.5983
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0028 0.0007
Brugia malayi Dopamine receptor 0.0034 0.0149 0.0198
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.067 0.1146
Loa Loa (eye worm) hypothetical protein 0.0391 0.4901 0.8382
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0112 0.6503
Brugia malayi Melatonin receptor type 1A 0.0034 0.0149 0.0198
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0158 0.0449
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0149 0.0124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0149 0.0146
Schistosoma mansoni endoplasmin 0.0031 0.0112 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0149 0.0124
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0149 0.0124
Entamoeba histolytica hypothetical protein 0.0034 0.0156 0.1641
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0149 0.0146
Echinococcus granulosus heat shock protein 0.0031 0.0112 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.028 0.0301
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0025 0.0044
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0028 1
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Loa Loa (eye worm) hypothetical protein 0.0143 0.1596 0.273
Loa Loa (eye worm) hypothetical protein 0.0346 0.4307 0.7366
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0112 0.1177
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0149 0.0124
Echinococcus multilocularis Niemann Pick C1 protein 0.0094 0.095 0.0926
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0112 0.6503
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0158 0.0449
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0225
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0112 0.6503
Brugia malayi Serotonin receptor 0.0034 0.0149 0.0198
Echinococcus granulosus orexin receptor type 2 0.0034 0.0149 0.0146
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0504 0.0668
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0149 0.0124
Echinococcus granulosus microtubule associated protein 2 0.0659 0.8465 1
Echinococcus multilocularis heat shock protein 90 0.0031 0.0112 0.0086
Trypanosoma brucei heat shock protein, putative 0.0031 0.0112 0.6503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.015
Echinococcus multilocularis endoplasmin 0.0025 0.0028 0.0002
Loa Loa (eye worm) hypothetical protein 0.0181 0.2106 0.3601
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.005 0.0083
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0028 0.0007
Brugia malayi hypothetical protein 0.0025 0.0025 0.0034
Entamoeba histolytica hypothetical protein 0.0034 0.0156 0.1641
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0149 0.0146
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0146
Echinococcus granulosus sex peptide receptor 0.0034 0.0149 0.0146
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0149 0.0255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0149 0.0124
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0236 0.0249
Echinococcus multilocularis chromobox protein 1 0.0067 0.0584 0.056
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0149 0.0146
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0149 0.0198
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0112 0.6503
Echinococcus granulosus serotonin transporter 0.0073 0.067 0.0764
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0236 0.0403
Echinococcus multilocularis somatostatin receptor 0.0034 0.0149 0.0124
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.5993 0.5983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.028 0.0301
Schistosoma mansoni amine GPCR 0.0034 0.0149 0.0146
Loa Loa (eye worm) endoplasmin 0.0031 0.0112 0.0191
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0112 1
Brugia malayi putative neuropeptide receptor 0.0034 0.0149 0.0198
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0149 0.0146
Brugia malayi follicle stimulating hormone receptor 0.0034 0.0149 0.0198
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0158 0.0449
Onchocerca volvulus 0.0034 0.0149 0.0805
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.028 0.0479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Schistosoma mansoni heat shock protein 0.0031 0.0112 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0149 0.0124
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0025 0.1612
Schistosoma mansoni tar DNA-binding protein 0.006 0.0504 0.0566
Schistosoma mansoni microtubule-associated protein tau 0.0659 0.8465 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0094 0.095 0.1624
Echinococcus multilocularis protein dispatched 1 0.0046 0.0311 0.0287
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0149 0.0124
Schistosoma mansoni amine GPCR 0.0034 0.0149 0.0146
Echinococcus granulosus biogenic amine 5HT receptor 0.0181 0.2106 0.2465
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0391 0.4901 0.5777
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0247 0.298 0.3951
Schistosoma mansoni biogenic amine receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0149 0.0124
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0025 0.0044
Brugia malayi hypothetical protein 0.0034 0.0149 0.0198
Echinococcus multilocularis heat shock protein 0.0031 0.0112 0.0086
Loa Loa (eye worm) TAR-binding protein 0.006 0.0504 0.0861
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0149 0.0146
Schistosoma mansoni alpha glucosidase 0.0035 0.0158 0.0157
Echinococcus granulosus heat shock protein 90 0.0031 0.0112 0.0102
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0112 0.6503
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0149 0.0255
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0158 0.0133
Brugia malayi TAR-binding protein 0.006 0.0504 0.0668
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0149 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.028 0.0301
Brugia malayi sulfakinin receptor protein 0.0034 0.0149 0.0198
Echinococcus granulosus g protein coupled receptor 0.0034 0.0149 0.0146
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Brugia malayi Muscleblind-like protein 0.0143 0.1596 0.2117
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0236 0.0711
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0149 0.0146
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0149 0.0146
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0028 0.1748
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0462 0.5847 0.5837
Brugia malayi Dopamine receptor protein 2 0.0034 0.0149 0.0198
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0158 1
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1851 0.6181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0044
Echinococcus granulosus somatostatin receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.028 0.0255
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0236 0.0211
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0158 0.027
Schistosoma mansoni alpha-glucosidase 0.0134 0.148 0.1724
Schistosoma mansoni neuropeptide receptor 0.0034 0.0149 0.0146
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0112 0.6503
Trichomonas vaginalis glucosylceramidase, putative 0.0247 0.298 1
Onchocerca volvulus 0.0034 0.0149 0.0805
Leishmania major heat shock protein 83-1 0.0031 0.0112 0.7067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0255
Loa Loa (eye worm) hypothetical protein 0.0073 0.067 0.1146
Schistosoma mansoni neuropeptide receptor 0.0034 0.0149 0.0146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0149 0.0124
Entamoeba histolytica hypothetical protein 0.0034 0.0156 0.1641
Onchocerca volvulus 0.0034 0.0149 0.0805
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0149 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.028 0.0255
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0146
Brugia malayi GnHR receptor homolog 0.0034 0.0149 0.0198
Onchocerca volvulus 0.0034 0.0149 0.0805
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0149 0.0198

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20 nM Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal raphe ChEMBL. 12482441
IC50 (binding) = 20 nM Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal raphe ChEMBL. 12482441
IC50 (binding) = 410 nM Inhibitory concentration of the compound required against Alpha-2 adrenergic receptor in rat cortex [3H]-clonidine ChEMBL. 12482441
IC50 (binding) = 410 nM Inhibitory concentration of the compound required against Alpha-2 adrenergic receptor in rat cortex [3H]-clonidine ChEMBL. 12482441
IC50 (binding) = 700 nM Inhibitory concentration of the compound required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101 ChEMBL. 12482441
IC50 (binding) = 700 nM Inhibitory concentration of the compound required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101 ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HT ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergine ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-HT uptake in rat cortex ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HT ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergine ChEMBL. 12482441
IC50 (binding) > 1000 nM Inhibitory concentration of the compound required against 5-HT uptake in rat cortex ChEMBL. 12482441
IC50 (binding) = 1700 nM Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatum ChEMBL. 12482441
IC50 (binding) = 1700 nM Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatum ChEMBL. 12482441
IC50 (binding) = 11000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]-spiperone ChEMBL. 12482441
IC50 (binding) = 11000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]-spiperone ChEMBL. 12482441
IC50 (binding) = 13000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HT ChEMBL. 12482441
IC50 (binding) = 13000 nM Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HT ChEMBL. 12482441
Motor activity (functional) = 4700 Counts In vivo motor activity of the compound determined in rat at 0.1 mg/kg of ip administration ChEMBL. 12482441
Time (functional) = 104 s Social interaction time determined in vivo in rat at 0.1 mg/kg of ip administration ChEMBL. 12482441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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