Detailed information for compound 1647373

Basic information

Technical information
  • TDR Targets ID: 1647373
  • Name: 2,3,5-trichloro-6-[2-(1,3-thiazol-2-ylamino)e thyl]benzene-1,4-diol
  • MW: 339.625 | Formula: C11H9Cl3N2O2S
  • H donors: 3 H acceptors: 3 LogP: 4.4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(CCNc2nccs2)c(Cl)c(c(c1Cl)Cl)O
  • InChi: 1S/C11H9Cl3N2O2S/c12-6-5(1-2-15-11-16-3-4-19-11)9(17)7(13)8(14)10(6)18/h3-4,17-18H,1-2H2,(H,15,16)
  • InChiKey: GRAQIRKMUUFLSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3,5-trichloro-6-[2-(thiazol-2-ylamino)ethyl]benzene-1,4-diol
  • 2,3,5-trichloro-6-[2-(2-thiazolylamino)ethyl]benzene-1,4-diol
  • 2,3,5-trichloro-6-[2-(thiazol-2-ylamino)ethyl]hydroquinone
  • 2-[(2-thiazolyl)amino]ethyl-3,5,6-trichlorohydroquinone
  • NSC724208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G-protein coupled receptor 0.0015 0.0093 0.0409
Schistosoma mansoni hypothetical protein 0.0018 0.0125 0.021
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0093 0.1318
Echinococcus granulosus serotonin receptor 0.0015 0.0093 0.1318
Echinococcus granulosus nibrin 0.0011 0.0059 0.0828
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0048 0.0048
Schistosoma mansoni cell adhesion molecule 0.0015 0.01 0.0168
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0015 0.0093 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0093 0.0093
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni nephrin 0.0012 0.0067 0.0113
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0093 0.0093
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0059 0.0059
Schistosoma mansoni topbp1 0.0011 0.0059 0.0099
Brugia malayi Melatonin receptor type 1A 0.0015 0.0093 0.0409
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0093 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0067 0.0296
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0125 0.1759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0093 0.0093
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni hypothetical protein 0.0015 0.0093 0.0157
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0093 0.0409
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0037 0.0061
Echinococcus multilocularis roundabout 2 0.0015 0.01 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0093 0.0409
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0093 0.0093
Schistosoma mansoni ets 0.0011 0.0048 0.0081
Brugia malayi Fli-1 protein 0.022 0.228 1
Schistosoma mansoni ets-related 0.022 0.228 0.3835
Schistosoma mansoni hypothetical protein 0.0011 0.0048 0.0081
Echinococcus granulosus roundabout 2 0.0015 0.01 0.1412
Schistosoma mansoni ets-related 0.0011 0.0048 0.0081
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0048 0.0684
Schistosoma mansoni amine GPCR 0.0015 0.0093 0.0157
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0093 0.1318
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0093 0.0093
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0093 0.0409
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0018 0.0125 0.021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0296
Schistosoma mansoni hypothetical protein 0.0564 0.5945 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0037 0.0061
Brugia malayi Fibronectin type III domain containing protein 0.0012 0.0067 0.0296
Brugia malayi ORL1-like opioid receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.016
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0093 0.0093
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0093 0.0093
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0048 0.0684
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0062 0.0596 0.2616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Echinococcus granulosus twitchin 0.0009 0.0037 0.0515
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0303
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0093 0.1318
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0093 0.0409
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi sulfakinin receptor protein 0.0015 0.0093 0.0409
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0093 0.1318
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0093 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Echinococcus granulosus orexin receptor type 2 0.0015 0.0093 0.1318
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0125 0.0547
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0093 0.1318
Schistosoma mansoni biogenic amine receptor 0.0015 0.0093 0.0157
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0059 0.5
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0093 0.0093
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Echinococcus multilocularis protein C ets 2 0.0011 0.0048 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Brugia malayi putative neuropeptide receptor 0.0015 0.0093 0.0409
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0504 0.0848
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0059 0.5
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0048 0.0048
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0093 0.0157
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0343 0.1504
Brugia malayi neuropeptide F receptor 0.0015 0.0093 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus fmrfamide receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0093 0.0409
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0048 0.0212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0048 0.0212
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0093 0.0093
Echinococcus multilocularis nibrin 0.0011 0.0059 0.0059
Brugia malayi Dopamine receptor 0.0015 0.0093 0.0409
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.016
Onchocerca volvulus 0.0015 0.0093 1
Brugia malayi topoisomerase 0.0011 0.0059 0.0257
Echinococcus granulosus neuropeptide receptor 0.0015 0.0093 0.1318
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0093 0.0093
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0069 0.0976
Brugia malayi DKFZp564C0469 protein 0.0011 0.0059 0.0257
Schistosoma mansoni hypothetical protein 0.0018 0.0125 0.021
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0093 0.0409
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0504 0.2211
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0048 0.0048
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0093 0.1318
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Schistosoma mansoni amine GPCR 0.0015 0.0093 0.0157
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0093 0.1318
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0093 0.0409
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0048 0.0212
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0048 0.0684
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0093 0.1318
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni histamine h1 receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0048 0.0212
Onchocerca volvulus 0.0015 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0093 0.0093
Brugia malayi Dopamine receptor protein 1 0.0015 0.0093 0.0409
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus sex peptide receptor 0.0015 0.0093 0.1318
Brugia malayi neuropeptide F receptor 0.0015 0.0093 0.0409
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0093 0.1318
Echinococcus granulosus g protein coupled receptor 0.0015 0.0093 0.1318
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0093 0.0093
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus multilocularis Immunoglobulin 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0093 0.0409
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0078 0.0343
Echinococcus granulosus g protein coupled receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0093 0.0409
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0059 0.0257
Echinococcus multilocularis GPCR, family 2 0.0018 0.0125 0.0125
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi AKH receptor 0.0015 0.0093 0.0409
Onchocerca volvulus 0.0015 0.0093 1
Brugia malayi G protein-coupled receptor 0.0015 0.0093 0.0409
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0059 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0125 0.0547
Brugia malayi Ets-domain containing protein 0.0011 0.0048 0.0212
Echinococcus granulosus protein C ets 2 0.0011 0.0048 0.0684
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0048 0.0684
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0059 0.5
Brugia malayi hypothetical protein 0.0012 0.0067 0.0296
Brugia malayi Serotonin receptor 0.0015 0.0093 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0504 0.0848
Schistosoma mansoni hypothetical protein 0.0018 0.0125 0.021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0093 0.0409
Chlamydia trachomatis DNA ligase 0.0011 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0531 0.2329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis serotonin receptor 0.0015 0.0093 0.0093
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0093 0.0409
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0547
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0059 0.5
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0708 1
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0059 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Brugia malayi larval opioid receptor 0.0015 0.0093 0.0409
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0093 0.0093
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0093 0.1318
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0059 0.0257
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0296
Echinococcus granulosus g protein coupled receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0059 1
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0093 0.1318
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Loa Loa (eye worm) fli-1 protein 0.022 0.228 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0059 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Echinococcus granulosus somatostatin receptor 0.0015 0.0093 0.1318
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0708 0.0708
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0093 0.1318
Brugia malayi RE15519p 0.0015 0.0093 0.0409
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Schistosoma mansoni amine GPCR 0.0015 0.0093 0.0157
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni DNA ligase IV 0.0011 0.0059 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0531 0.2329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0093 0.1318
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0093 0.0157
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0093 0.0157
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0093 0.1318
Schistosoma mansoni neuropeptide receptor 0.0015 0.0093 0.0157
Brugia malayi Ets-domain containing protein 0.0072 0.0708 0.3107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0048 0.0684
Schistosoma mansoni amine GPCR 0.0015 0.0093 0.0157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0048 0.0048
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0093 0.1318
Schistosoma mansoni biogenic amine receptor 0.0015 0.0093 0.0157
Echinococcus granulosus hypothetical protein 0.0015 0.0093 0.1318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0093 0.0093
Brugia malayi hypothetical protein 0.0011 0.0059 0.0257
Loa Loa (eye worm) hypothetical protein 0.0038 0.0343 0.1504
Brugia malayi G-protein coupled receptor 0.0015 0.0093 0.0409
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0059 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0093 0.1318
Brugia malayi transcription factor E74 isoform 0.0011 0.0048 0.0212
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0212
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0093 0.0409
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0093 0.1318
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0125 0.0547
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni hypothetical protein 0.0038 0.0343 0.0577
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni neuropeptide receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Echinococcus multilocularis neuroglian 0.0009 0.0037 0.0037
Treponema pallidum DNA ligase (lig) 0.0011 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0059 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0093 0.0093
Onchocerca volvulus 0.0015 0.0093 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0093 0.0157
Echinococcus granulosus defective proboscis extension response 0.0009 0.0037 0.0515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0504 0.0504
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0708 0.3107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0125 0.1759
Brugia malayi Serotonin receptor 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0303
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0059 0.5
Echinococcus multilocularis serotonin receptor 0.0015 0.0093 0.0093
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0093 0.0093
Schistosoma mansoni vesicular amine transporter 0.0009 0.0037 0.0061
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus GPCR family 2 0.0018 0.0125 0.1759
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0093 0.0409
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0504 0.2211
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0015 0.0093 0.0157
Schistosoma mansoni amine GPCR 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0093 0.1318
Schistosoma mansoni gabp alpha 0.0072 0.0708 0.1192
Echinococcus granulosus neuropeptide receptor 0.0015 0.0093 0.1318
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0531 0.2329
Brugia malayi hypothetical protein 0.0011 0.0059 0.0257
Schistosoma mansoni hypothetical protein 0.0015 0.0093 0.0157
Brugia malayi Ets-domain containing protein 0.0072 0.0708 0.3107
Schistosoma mansoni myosin xvIII 0.0015 0.0093 0.0157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0093 0.0157
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0048 0.0684
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0125 0.0125
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0093 0.1318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0093 0.0157
Echinococcus multilocularis somatostatin receptor 0.0015 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0093 0.0093
Schistosoma mansoni topbp1 0.0011 0.0059 0.0099
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0093 0.0093
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0093 0.0157
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0059 0.0099
Schistosoma mansoni elf1 0.0011 0.0048 0.0081
Schistosoma mansoni opsin-like receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni opsin-like receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0504 0.7116
Schistosoma mansoni hypothetical protein 0.0011 0.0048 0.0081
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0093 0.0157
Echinococcus multilocularis ets variant gene 4 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0093 0.0157
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0093 0.0409
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0048 0.0212
Echinococcus granulosus allatostatin A receptor 0.0015 0.0093 0.1318
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0059 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0059 0.5
Schistosoma mansoni neuropeptide receptor 0.0015 0.0093 0.0157
Echinococcus granulosus neuroglian 0.0009 0.0037 0.0515
Onchocerca volvulus 0.0015 0.0093 1
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0093 0.1318
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0059 0.0828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0504 0.0848
Brugia malayi GnHR receptor homolog 0.0015 0.0093 0.0409
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0059 1
Schistosoma mansoni biogenic amine receptor 0.0015 0.0093 0.0157
Onchocerca volvulus 0.0015 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0504 0.7116
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0093 0.1318
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0093 0.1318
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0504 0.0504
Schistosoma mansoni opsin-like receptor 0.0015 0.0093 0.0157
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0013 0.0078 0.0343
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0093 0.0157
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0093 0.1318
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0093 0.0093
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0093 0.1318
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0093 0.0093
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0093 0.0093
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0093 0.0093
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0048 0.0081
Brugia malayi hypothetical protein 0.0015 0.0093 0.0409
Echinococcus granulosus Immunoglobulin 0.0009 0.0037 0.0515
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0531 0.2329
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0093 0.0093
Brugia malayi Dopamine receptor protein 2 0.0015 0.0093 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0409
Schistosoma mansoni adenoreceptor 0.0015 0.0093 0.0157
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0093 0.0409
Echinococcus multilocularis Immunoglobulin 0.0009 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0015 0.0093 0.0157
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0048 0.0048
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0048 0.0048
Echinococcus multilocularis sex peptide receptor 0.0015 0.0093 0.0093
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0093 0.0157

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.775 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.657 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.435 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.191 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.165 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.784 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.735 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.722 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.49 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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