Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0248 | 0.3221 | 0.3205 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0101 | 0.0945 | 0.0945 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0685 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0205 | 0.2553 | 0.2536 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0119 | 0.0096 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0685 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0101 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.3765 | 0.3751 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0685 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0283 | 0.3765 | 0.3751 |
Loa Loa (eye worm) | sirtuin 4 | 0.0101 | 0.0945 | 0.0924 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0101 | 0.0945 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0685 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0047 | 0.0103 | 0.0103 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0685 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0115 | 0.0091 |
Loa Loa (eye worm) | transcriptional regulator | 0.0685 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0103 | 0.008 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0047 | 0.0103 | 0.008 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0205 | 0.2553 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0283 | 0.3765 | 0.3751 |
Onchocerca volvulus | 0.0048 | 0.0119 | 0.0064 | |
Echinococcus multilocularis | geminin | 0.0379 | 0.5254 | 0.5243 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0101 | 0.0945 | 0.0924 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 7 | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | steroid hormone receptor | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | carboxylesterase | 0.0283 | 0.3765 | 0.3751 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0103 | 0.008 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0101 | 0.0945 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0101 | 0.0945 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0156 | 0.1801 | 0.0946 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1528 | 0.1508 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0103 | 0.0103 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0164 | 0.1928 | 0.1086 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.0882 | 0.0861 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0101 | 0.0945 | 0.0069 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0048 | 0.0119 | 0.0096 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0685 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0047 | 0.0103 | 0.0103 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0685 | 1 | 1 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0685 | 1 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0685 | 1 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0685 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0047 | 0.0103 | 0.0103 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0101 | 0.0945 | 0.0069 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.0882 | 0.0861 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0047 | 0.0103 | 0.0103 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0048 | 0.0119 | 0.0096 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0119 | 0.0119 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.5254 | 0.5254 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0119 | 0.0096 |
Entamoeba histolytica | NAD-dependent deacetylase 1, putative | 0.0101 | 0.0945 | 0.0069 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0101 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0198 | 0.0175 |
Loa Loa (eye worm) | transcriptional regulator | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0685 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0882 | 0.0861 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0047 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0101 | 0.0945 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0103 | 0.008 |
Onchocerca volvulus | 0.0048 | 0.0119 | 0.0064 | |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.2553 | 0.2536 |
Echinococcus granulosus | geminin | 0.0379 | 0.5254 | 0.5243 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0119 | 0.0096 |
Echinococcus granulosus | tumor protein p63 | 0.0361 | 0.4984 | 0.4972 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0119 | 0.0096 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0119 | 0.0119 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0047 | 0.0103 | 0.0103 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0103 | 0.008 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0101 | 0.0945 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0283 | 0.3765 | 0.3751 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0048 | 0.0119 | 0.0119 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.3765 | 0.3751 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0047 | 0.0103 | 0.008 |
Leishmania major | squalene monooxygenase-like protein | 0.0164 | 0.1928 | 0.1086 |
Loa Loa (eye worm) | transcriptional regulator | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0119 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0086 | 0.0719 | 0.7268 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0103 | 0.008 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0685 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0101 | 0.0945 | 0.0924 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0047 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0061 | 0.0321 | 0.0298 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0198 | 0.0198 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0164 | 0.1928 | 0.1086 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0164 | 0.1928 | 0.1086 |
Plasmodium vivax | hypothetical protein, conserved | 0.0101 | 0.0945 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Carboxylesterase family protein | 0.0283 | 0.3765 | 0.3751 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 7 | 0.0101 | 0.0945 | 0.0924 |
Echinococcus granulosus | neuroligin | 0.0048 | 0.0119 | 0.0096 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0685 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0048 | 0.0119 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0945 | 0.0924 |
Schistosoma mansoni | gliotactin | 0.0048 | 0.0119 | 0.0119 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0048 | 0.0119 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0103 | 0.008 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0.0119 | 0.0096 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0101 | 0.0945 | 0.5 |
Leishmania major | lanosterol synthase, putative | 0.0135 | 0.1469 | 0.0579 |
Echinococcus granulosus | acetylcholinesterase | 0.0283 | 0.3765 | 0.3751 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0101 | 0.0945 | 0.0924 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.0791 | 0.0769 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0283 | 0.3765 | 0.3751 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0048 | 0.0119 | 0.0096 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Echinococcus multilocularis | tumor protein p63 | 0.0361 | 0.4984 | 0.4972 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1528 | 0.1508 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | acetylcholinesterase | 0.0283 | 0.3765 | 0.3751 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0048 | 0.0119 | 0.0119 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0283 | 0.3765 | 0.3765 |
Onchocerca volvulus | 0.0048 | 0.0119 | 0.0064 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0103 | 0.008 |
Giardia lamblia | Hypothetical protein | 0.0685 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0048 | 0.0119 | 0.0096 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 6 | 0.0101 | 0.0945 | 0.0924 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | nuclear hormone receptor | 0.0047 | 0.0103 | 0.008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0047 | 0.0103 | 0.0103 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0047 | 0.0103 | 0.008 |
Brugia malayi | follicle stimulating hormone receptor | 0.0248 | 0.3221 | 0.3205 |
Schistosoma mansoni | nuclear hormone receptor | 0.0047 | 0.0103 | 0.0103 |
Schistosoma mansoni | lipoxygenase | 0.0061 | 0.0321 | 0.0321 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0101 | 0.0945 | 0.0924 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0047 | 0.0103 | 0.0103 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 6 | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0047 | 0.0103 | 0.008 |
Trypanosoma brucei | lanosterol synthase | 0.0156 | 0.1801 | 0.0946 |
Echinococcus multilocularis | acetylcholinesterase | 0.0283 | 0.3765 | 0.3751 |
Onchocerca volvulus | 0.0048 | 0.0119 | 0.0064 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0119 | 0.0119 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.0905 | 0.0905 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0.0119 | 0.0096 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0119 | 0.0096 |
Schistosoma mansoni | thyroid hormone receptor | 0.0047 | 0.0103 | 0.0103 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0685 | 1 | 1 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0101 | 0.0945 | 0.5 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0101 | 0.0945 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0047 | 0.0103 | 0.008 |
Schistosoma mansoni | acetylcholinesterase | 0.0048 | 0.0119 | 0.0119 |
Echinococcus granulosus | carboxylesterase 5A | 0.0283 | 0.3765 | 0.3751 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0048 | 0.0119 | 0.0096 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0156 | 0.1801 | 0.0946 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.5254 | 0.5254 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0047 | 0.0103 | 0.008 |
Leishmania major | silent information regulator 2, putative | 0.0685 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0101 | 0.0945 | 0.0924 |
Schistosoma mansoni | coup transcription factor | 0.0047 | 0.0103 | 0.0103 |
Onchocerca volvulus | 0.0053 | 0.0198 | 0.0388 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0061 | 0.0321 | 0.0298 |
Brugia malayi | nuclear receptor NHR-88 | 0.0047 | 0.0103 | 0.008 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.0791 | 0.0769 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.0882 | 0.0861 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0101 | 0.0945 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0119 | 0.0096 |
Onchocerca volvulus | 0.0048 | 0.0119 | 0.0064 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0169 | 0.0146 |
Echinococcus granulosus | FTZ F1 alpha | 0.0047 | 0.0103 | 0.008 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0047 | 0.0103 | 0.008 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MIC (functional) | = 16 ug ml-1 | Antimycobacterial activity against Mycobacterium avium CIP 103317 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antibacterial activity against Mycobacterium smegmatis CIP 103599. | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium gordonae CIP 6427 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium marinum CIP 6423 | ChEMBL. | 9873650 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis CIP 103471 | ChEMBL. | 9873650 |
MTD50 (functional) | 0 ug ml-1 | Compound was tested for cytotoxicity against VERO cells; Not determined | ChEMBL. | 9873650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.