Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | conserved hypotetical protein | 0.0176 | 0.2294 | 0.4272 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0372 | 0.537 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0197 | 0.2624 | 0.2624 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0303 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | coup transcription factor | 0.0372 | 0.537 | 0.537 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0372 | 0.537 | 0.537 |
Brugia malayi | nuclear receptor NHR-67 | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0372 | 0.537 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0372 | 0.537 | 0.537 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0176 | 0.2294 | 0.4272 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0176 | 0.2294 | 0.2294 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0372 | 0.537 | 0.537 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0372 | 0.537 | 0.537 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0176 | 0.2294 | 0.2294 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0372 | 0.537 | 0.537 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0093 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0176 | 0.2294 | 0.2294 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0176 | 0.2294 | 0.2294 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0064 | 0.0064 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0082 | 0.0153 |
Loa Loa (eye worm) | DR-78 | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0372 | 0.537 | 1 |
Brugia malayi | ecdysone receptor | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | nuclear hormone receptor | 0.0176 | 0.2294 | 0.2294 |
Onchocerca volvulus | 0.0229 | 0.3136 | 0.5839 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0372 | 0.537 | 0.537 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0082 | 0.0082 |
Brugia malayi | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Schistosoma mansoni | nuclear receptor | 0.0176 | 0.2294 | 0.2294 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0372 | 0.537 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0176 | 0.2294 | 0.2294 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0372 | 0.537 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0197 | 0.2624 | 0.2624 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0064 | 0.0119 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0372 | 0.537 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0372 | 0.537 | 0.537 |
Brugia malayi | nuclear hormone receptor | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0197 | 0.2624 | 0.2624 |
Brugia malayi | nuclear receptor RXR | 0.0197 | 0.2624 | 0.4886 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0176 | 0.2294 | 0.4272 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0176 | 0.2294 | 0.2294 |
Onchocerca volvulus | 0.0176 | 0.2294 | 0.4272 | |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0176 | 0.2294 | 0.4272 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0064 | 0.0119 |
Brugia malayi | nuclear receptor RXR | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0303 | 0.0564 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0372 | 0.537 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0093 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0093 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0082 | 0.0082 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.0697 | 0.0697 |
Onchocerca volvulus | 0.0372 | 0.537 | 1 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | nuclear hormone receptor | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0372 | 0.537 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0197 | 0.2624 | 0.2624 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0372 | 0.537 | 0.537 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0082 | 0.0153 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0303 | 0.0564 |
Brugia malayi | nuclear receptor NHR-88 | 0.0372 | 0.537 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0372 | 0.537 | 1 |
Brugia malayi | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0372 | 0.537 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0372 | 0.537 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.27 | 0.5028 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0372 | 0.537 | 0.537 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0372 | 0.537 | 0.537 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0303 | 0.0564 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0093 | 0.0173 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0197 | 0.2624 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0305 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0176 | 0.2294 | 0.2294 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3136 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0162 | 0.0162 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0372 | 0.537 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0372 | 0.537 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0372 | 0.537 | 0.537 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0197 | 0.2624 | 0.4886 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0532 | 0.7869 | 0.7869 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.0994 | 0.1851 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0372 | 0.537 | 0.537 |
Brugia malayi | nuclear receptor NHR-88 | 0.0176 | 0.2294 | 0.4272 |
Brugia malayi | nuclear hormone receptor | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0372 | 0.537 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0372 | 0.537 | 0.537 |
Schistosoma mansoni | nuclear receptor | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0372 | 0.537 | 0.537 |
Brugia malayi | steroid hormone receptor | 0.0372 | 0.537 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0176 | 0.2294 | 0.2294 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0176 | 0.2294 | 0.2294 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0372 | 0.537 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0372 | 0.537 | 0.537 |
Brugia malayi | tailless protein | 0.0176 | 0.2294 | 0.4272 |
Onchocerca volvulus | 0.0176 | 0.2294 | 0.4272 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.046 | 0.0856 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0176 | 0.2294 | 0.2294 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0372 | 0.537 | 0.537 |
Brugia malayi | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0372 | 0.537 | 0.537 |
Brugia malayi | ecdysteroid receptor | 0.0372 | 0.537 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0093 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0372 | 0.537 | 0.537 |
Echinococcus granulosus | FTZ F1 alpha | 0.0372 | 0.537 | 0.537 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0372 | 0.537 | 0.537 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0372 | 0.537 | 0.537 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0372 | 0.537 | 0.537 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0176 | 0.2294 | 0.4272 |
Brugia malayi | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0372 | 0.537 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0176 | 0.2294 | 0.2294 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0176 | 0.2294 | 0.4272 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.0994 | 0.0994 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0372 | 0.537 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0372 | 0.537 | 0.537 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0372 | 0.537 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.27 | 0.5028 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2294 | 0.4272 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2624 | 0.4886 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0162 | 0.0162 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0197 | 0.2624 | 0.4886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.086 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.