Detailed information for compound 1647976

Basic information

Technical information
  • TDR Targets ID: 1647976
  • Name: N-[(2,4-dichlorophenyl)methyl]-3-thiophen-2-y lquinoxalin-2-amine
  • MW: 386.298 | Formula: C19H13Cl2N3S
  • H donors: 1 H acceptors: 2 LogP: 5.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)CNc1nc2ccccc2nc1c1cccs1
  • InChi: 1S/C19H13Cl2N3S/c20-13-8-7-12(14(21)10-13)11-22-19-18(17-6-3-9-25-17)23-15-4-1-2-5-16(15)24-19/h1-10H,11H2,(H,22,24)
  • InChiKey: KEXQXBOEEOIAKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2,4-dichlorophenyl)methyl]-3-(2-thienyl)quinoxalin-2-amine
  • N-[(2,4-dichlorophenyl)methyl]-3-(2-thienyl)-2-quinoxalinamine
  • (2,4-dichlorobenzyl)-[3-(2-thienyl)quinoxalin-2-yl]amine
  • N-[(2,4-dichlorophenyl)methyl]-3-thiophen-2-yl-quinoxalin-2-amine
  • NCI60_012376
  • AIDS-136255
  • AIDS136255
  • N-(2,4-Dichlorobenzyl)-3-(2-thienyl)-2-quinoxalinamine
  • N-(2,4-Dichlorobenzyl)-N-(3-(2-thienyl)-2-quinoxalinyl)amine
  • NSC637412

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1348 0.1348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0134 0.1471 0.3952
Onchocerca volvulus Protein ultraspiracle homolog 0.0285 0.3343 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1115 0.2994
Loa Loa (eye worm) hypothetical protein 0.015 0.1672 0.449
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.0901 0.2419
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0148 0.0397
Schistosoma mansoni nuclear receptor 0.0134 0.1471 0.1471
Schistosoma mansoni nuclear receptor 0.0134 0.1471 0.1471
Schistosoma mansoni hypothetical protein 0.0028 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0285 0.3343 0.8981
Brugia malayi hypothetical protein 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.015 0.1672 0.449
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.1471 0.3952
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0285 0.3343 0.8981
Echinococcus granulosus peregrin 0.0032 0.0201 0.054
Brugia malayi jmjC domain containing protein 0.0106 0.1115 0.2994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0285 0.3343 0.8981
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0134 0.1471 0.3952
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0285 0.3343 0.3343
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0 0.5
Schistosoma mansoni zinc finger protein 0.0134 0.1471 0.1471
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0285 0.3343 0.8981
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.015 0.1672 0.449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0148 0.0397
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0285 0.3343 0.8981
Brugia malayi Muscleblind-like protein 0.0315 0.3723 1
Schistosoma mansoni hypothetical protein 0.0301 0.3543 0.3543
Schistosoma mansoni hypothetical protein 0.0028 0.0148 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.1672 0.449
Echinococcus multilocularis lamin dm0 0.0023 0.0087 0.0234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0285 0.3343 0.8981
Onchocerca volvulus 0.0167 0.1881 0.5509
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.015 0.1672 0.449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0285 0.3343 0.8981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0285 0.3343 0.8981
Echinococcus multilocularis lamin 0.0023 0.0087 0.0234
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.015 0.1672 0.1672
Brugia malayi nuclear receptor NHR-88 0.0285 0.3343 0.8981
Schistosoma mansoni lamin 0.0023 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0552 0.1483
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0285 0.0285
Brugia malayi nuclear receptor RXR 0.0134 0.1471 0.3952
Echinococcus granulosus geminin 0.0301 0.3543 0.9518
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.1672 0.449
Schistosoma mansoni thyroid hormone receptor 0.0285 0.3343 0.3343
Brugia malayi ecdysone receptor 0.0134 0.1471 0.3952
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0134 0.1471 0.3952
Schistosoma mansoni nuclear receptor nhr-48 0.0134 0.1471 0.1471
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0201 0.054
Echinococcus multilocularis FTZ F1 alpha 0.0285 0.3343 0.8981
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0148 0.0397
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0087 0.0234
Echinococcus granulosus FTZ F1 alpha 0.0285 0.3343 0.8981
Brugia malayi nuclear receptor NHR-67 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Onchocerca volvulus Bile acid receptor homolog 0.0285 0.3343 1
Schistosoma mansoni hypothetical protein 0.0028 0.0148 0.0148
Brugia malayi Bromodomain containing protein 0.0032 0.0201 0.054
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1348 0.3622
Brugia malayi intermediate filament protein 0.0023 0.0087 0.0234
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0285 0.3343 0.3343
Onchocerca volvulus 0.0285 0.3343 1
Schistosoma mansoni nuclear hormone receptor 0.0285 0.3343 0.3343
Echinococcus multilocularis GPCR, family 2 0.0028 0.0148 0.0397
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0285 0.3343 0.8981
Loa Loa (eye worm) hypothetical protein 0.0055 0.0488 0.131
Schistosoma mansoni hypothetical protein 0.0301 0.3543 0.3543
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0285 0.3343 0.8981
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0167 0.1881 0.5053
Schistosoma mansoni coup transcription factor 0.0285 0.3343 0.3343
Echinococcus granulosus thyroid hormone receptor alpha 0.0134 0.1471 0.3952
Trichomonas vaginalis ap endonuclease, putative 0.0016 0 0.5
Brugia malayi hypothetical protein 0.0134 0.1471 0.3952
Giardia lamblia PHD finger protein 15 0.0032 0.0201 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0285 0.3343 0.8981
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1348 0.1348
Echinococcus granulosus muscleblind protein 0.0315 0.3723 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0285 0.3343 0.8981
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0148 0.0397
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0201 0.054
Brugia malayi orphan nuclear receptor NR2E1 0.0134 0.1471 0.3952
Schistosoma mansoni retinoid-x-receptor (RXR) 0.015 0.1672 0.1672
Echinococcus granulosus ecdysone induced protein 78C 0.0285 0.3343 0.8981
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0201 1
Loa Loa (eye worm) RNA binding protein 0.0124 0.1348 0.3622
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0285 0.3343 0.8981
Echinococcus multilocularis geminin 0.0301 0.3543 0.9518
Brugia malayi Nuclear hormone receptor-like 1 0.0285 0.3343 0.8981
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0148 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1348 0.1348
Brugia malayi steroid hormone receptor 0.0285 0.3343 0.8981
Loa Loa (eye worm) hypothetical protein 0.015 0.1672 0.449
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0285 0.3343 0.8981
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0285 0.3343 0.8981
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0201 0.0201
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0134 0.1471 0.1471
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0285 0.0767
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0285 0.3343 0.3343
Brugia malayi hypothetical protein 0.015 0.1672 0.449
Loa Loa (eye worm) hypothetical protein 0.006 0.0552 0.1483
Brugia malayi nuclear hormone receptor family member nhr-6 0.0134 0.1471 0.3952
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0148 0.0397
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.1471 0.3952
Echinococcus granulosus lamin dm0 0.0023 0.0087 0.0234
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Schistosoma mansoni hypothetical protein 0.006 0.0552 0.0552
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0285 0.3343 0.8981
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1348 0.1348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0285 0.3343 0.8981
Brugia malayi tailless protein 0.0134 0.1471 0.3952
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0285 0.3343 0.8981
Echinococcus multilocularis peregrin 0.0032 0.0201 0.054
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Schistosoma mansoni hypothetical protein 0.0032 0.0201 0.0201
Loa Loa (eye worm) nuclear receptor NHR-67 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0315 0.3723 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0285 0.3343 0.8981
Schistosoma mansoni intermediate filament proteins 0.0023 0.0087 0.0087
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0358 0.0962
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0087 0.0234
Brugia malayi photoreceptor-specific nuclear receptor 0.0285 0.3343 0.8981
Onchocerca volvulus 0.0134 0.1471 0.425
Brugia malayi nuclear hormone receptor 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Schistosoma mansoni nuclear hormone receptor 0.0134 0.1471 0.1471
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Loa Loa (eye worm) DR-78 0.0134 0.1471 0.3952
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.0901 0.2419
Loa Loa (eye worm) steroid hormone receptor 0.0285 0.3343 0.8981
Brugia malayi hypothetical protein 0.015 0.1672 0.449
Echinococcus granulosus intermediate filament protein 0.0023 0.0087 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0285 0.3343 0.8981
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0629 0.1688
Schistosoma mansoni lamin 0.0023 0.0087 0.0087
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0134 0.1471 0.3952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0285 0.3343 0.8981
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0358 0.0962
Trichomonas vaginalis ap endonuclease, putative 0.0016 0 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0134 0.1471 0.3952
Brugia malayi Nuclear hormone receptor E75 0.0134 0.1471 0.3952
Brugia malayi conserved hypotetical protein 0.0134 0.1471 0.3952
Brugia malayi nuclear hormone receptor 0.0285 0.3343 0.8981
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0148 0.0397
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0285 0.3343 0.8981
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0285 0.3343 0.8981
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.1471 0.425
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0234
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0201 0.054
Echinococcus granulosus nuclear receptor nhr 48 0.0134 0.1471 0.3952
Brugia malayi MH2 domain containing protein 0.0109 0.1162 0.3122
Loa Loa (eye worm) nuclear hormone receptor 0.0134 0.1471 0.3952
Echinococcus multilocularis nuclear receptor nhr 48 0.0134 0.1471 0.3952
Brugia malayi ecdysteroid receptor 0.0285 0.3343 0.8981
Brugia malayi hypothetical protein 0.0167 0.1881 0.5053
Echinococcus multilocularis thyroid hormone receptor alpha 0.0285 0.3343 0.8981
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0285 0.3343 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0285 0.3343 0.3343
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0134 0.1471 0.1471
Onchocerca volvulus 0.0134 0.1471 0.425
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Schistosoma mansoni thyroid hormone receptor 0.0285 0.3343 0.3343
Echinococcus multilocularis ecdysone induced protein 78C 0.0285 0.3343 0.8981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0285 0.3343 0.8981
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1348 0.3622
Brugia malayi PHD-finger family protein 0.0032 0.0201 0.054
Echinococcus multilocularis muscleblind protein 1 0.0315 0.3723 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0285 0.3343 0.3343
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0285 0.3343 0.8981
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0087 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0201 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0134 0.1471 0.425
Echinococcus granulosus GPCR family 2 0.0028 0.0148 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0285 0.3343 0.8981
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0285 0.3343 0.8981
Brugia malayi nuclear receptor RXR 0.015 0.1672 0.449
Loa Loa (eye worm) hypothetical protein 0.0134 0.1471 0.3952
Loa Loa (eye worm) transcription factor SMAD2 0.0109 0.1162 0.3122
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.0901 0.2419
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1348 0.3622
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0285 0.3343 0.8981
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1115 0.2994
Loa Loa (eye worm) hypothetical protein 0.0315 0.3723 1
Brugia malayi Nuclear hormone receptor E75 0.0134 0.1471 0.3952
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0285 0.3343 0.8981
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0285 0.0767
Schistosoma mansoni retinoic acid receptor RXR 0.0285 0.3343 0.3343
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1348 0.1348
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0844 0.0844
Loa Loa (eye worm) MH2 domain-containing protein 0.0109 0.1162 0.3122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.0901 0.2419
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Brugia malayi Steroid receptor seven-up type 2 0.0285 0.3343 0.8981
Brugia malayi nuclear receptor NHR-88 0.0134 0.1471 0.3952
Brugia malayi jmjC domain containing protein 0.0039 0.0285 0.0767
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0201 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0134 0.1471 0.3952
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.015 0.1672 0.449
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0285 0.3343 0.8981
Echinococcus granulosus lamin 0.0023 0.0087 0.0234
Echinococcus multilocularis muscleblind protein 0.0315 0.3723 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0285 0.3343 0.8981
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0148 0.0397
Loa Loa (eye worm) hypothetical protein 0.0285 0.3343 0.8981
Echinococcus multilocularis musashi 0.0023 0.0087 0.0234
Brugia malayi RNA binding protein 0.0124 0.1348 0.3622
Plasmodium falciparum phd finger protein, putative 0.0032 0.0201 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0285 0.3343 0.8981
Onchocerca volvulus Alhambra homolog 0.0032 0.0201 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0285 0.3343 0.8981
Brugia malayi TAR-binding protein 0.0124 0.1348 0.3622
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.022
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0134 0.1471 0.3952
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0285 0.3343 0.3343
Schistosoma mansoni RAR-like nuclear receptor 0.0285 0.3343 0.3343
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0285 0.0767
Brugia malayi nuclear hormone receptor family member odr-7 0.0134 0.1471 0.3952
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1348 0.3622
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0285 0.0285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0285 0.3343 0.3343
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0134 0.1471 0.3952
Loa Loa (eye worm) hypothetical protein 0.015 0.1672 0.449
Loa Loa (eye worm) hypothetical protein 0.015 0.1672 0.449
Echinococcus granulosus tar DNA binding protein 0.0124 0.1348 0.3622

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.884 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.66 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.164 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.124 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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