Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1157 | 0.3362 | 0.2662 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1157 | 0.3362 | 0.2662 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0749 | 0.1756 | 0.0887 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1157 | 0.3362 | 1 |
Brugia malayi | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1157 | 0.3362 | 1 |
Onchocerca volvulus | 0.1157 | 0.3362 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0749 | 0.1756 | 0.3331 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1157 | 0.3362 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1157 | 0.3362 | 1 |
Brugia malayi | nuclear hormone receptor | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0749 | 0.1756 | 0.3331 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1157 | 0.3362 | 1 |
Brugia malayi | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0611 | 0.1212 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1157 | 0.3362 | 0.2662 |
Schistosoma mansoni | coup transcription factor | 0.1157 | 0.3362 | 0.2662 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1157 | 0.3362 | 0.2662 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0611 | 0.1212 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0749 | 0.1756 | 0.3331 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1157 | 0.3362 | 0.2662 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1157 | 0.3362 | 0.2662 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.1157 | 0.3362 | 0.2662 |
Brugia malayi | nuclear receptor RXR | 0.0611 | 0.1212 | 0.1071 |
Brugia malayi | ecdysteroid receptor | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1157 | 0.3362 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0749 | 0.1756 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1157 | 0.3362 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1157 | 0.3362 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1157 | 0.3362 | 1 |
Brugia malayi | steroid hormone receptor | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0708 | 0.1592 | 0.0705 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0708 | 0.1592 | 0.0705 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1157 | 0.3362 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0749 | 0.1756 | 0.3331 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1157 | 0.3362 | 0.2662 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1157 | 0.3362 | 0.2662 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1157 | 0.3362 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0611 | 0.1212 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1157 | 0.3362 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1157 | 0.3362 | 0.2662 |
Brugia malayi | kinase, mitochondrial precursor | 0.0749 | 0.1756 | 0.3331 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0611 | 0.1212 | 0.1071 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0304 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0611 | 0.1212 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0611 | 0.1212 | 0.0285 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0749 | 0.1756 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1157 | 0.3362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1157 | 0.3362 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1157 | 0.3362 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1157 | 0.3362 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0611 | 0.1212 | 0.1071 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1157 | 0.3362 | 0.2662 |
Echinococcus granulosus | FTZ F1 alpha | 0.1157 | 0.3362 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0749 | 0.1756 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1157 | 0.3362 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1157 | 0.3362 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0611 | 0.1212 | 0.0285 |
Schistosoma mansoni | thyroid hormone receptor | 0.1157 | 0.3362 | 0.2662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.676 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.596 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.442 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.426 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.321 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.307 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.284 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.274 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.203 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.173 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.139 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.