Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0183 | 0.703 | 0.8319 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0028 | 0.0794 | 0.178 |
Brugia malayi | CXXC zinc finger family protein | 0.0061 | 0.2124 | 0.2854 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.1279 | 0.287 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.1406 | 0.3154 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.002 | 0.0488 | 0.1094 |
Echinococcus granulosus | serine protein kinase ATM | 0.0028 | 0.0791 | 0.1037 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0028 | 0.0794 | 0.2736 |
Brugia malayi | G-protein alpha subunit | 0.0008 | 0.001 | 0.0013 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.5558 | 0.5558 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0034 | 0.105 | 0.1242 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.105 | 0.141 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.1279 | 0.1719 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0028 | 0.0794 | 0.1041 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0028 | 0.0794 | 0.2736 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0028 | 0.0794 | 0.2736 |
Echinococcus multilocularis | cpg binding protein | 0.0064 | 0.2263 | 0.2969 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Loa Loa (eye worm) | glutathione reductase | 0.008 | 0.29 | 0.3897 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0434 | 0.0569 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.214 | 0.738 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0008 | 0.001 | 0.0013 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.214 | 0.2533 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Brugia malayi | beta-lactamase | 0.0034 | 0.105 | 0.141 |
Giardia lamblia | GTOR | 0.002 | 0.0488 | 0.3813 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0034 | 0.105 | 0.1242 |
Mycobacterium ulcerans | lipase LipD | 0.0034 | 0.105 | 0.1902 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.105 | 0.362 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0081 | 0.2943 | 0.3861 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.2124 | 0.2124 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0008 | 0.001 | 0.0013 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0183 | 0.703 | 0.8319 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0284 | 0.0373 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0434 | 0.0583 |
Trichomonas vaginalis | esterase, putative | 0.0034 | 0.105 | 0.7466 |
Plasmodium falciparum | thioredoxin reductase | 0.0028 | 0.0794 | 0.2736 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.214 | 0.2808 |
Onchocerca volvulus | 0.0034 | 0.105 | 0.4942 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.105 | 0.362 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0034 | 0.105 | 0.1242 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0008 | 0.001 | 0.001 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0028 | 0.0791 | 0.2726 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0008 | 0.001 | 0.0077 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.002 | 0.0488 | 0.1682 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0488 | 0.0655 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0028 | 0.0794 | 0.2736 |
Trichomonas vaginalis | GTP-binding protein (q) alpha-11 subunit, gna11, putative | 0.0008 | 0.001 | 0.0071 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0.001 | 0.0071 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.1299 | 0.1704 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0284 | 0.0284 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Brugia malayi | GTP-binding regulatory protein alpha chain - starfish, putative | 0.0008 | 0.001 | 0.0013 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.105 | 0.1242 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-6 subunit | 0.0008 | 0.001 | 0.0013 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0034 | 0.105 | 0.1377 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0203 | 0.785 | 1 |
Echinococcus granulosus | geminin | 0.0198 | 0.7622 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0008 | 0.001 | 0.0013 |
Brugia malayi | guanine nucleotide-binding protein alpha-7 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0008 | 0.001 | 0.001 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0028 | 0.0794 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0008 | 0.001 | 0.0071 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0284 | 0.0373 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.0488 | 0.1682 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1279 | 0.4411 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.0488 | 0.1682 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.0488 | 0.064 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.214 | 0.4802 |
Onchocerca volvulus | 0.0008 | 0.001 | 0.0047 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.214 | 1 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0008 | 0.001 | 0.001 |
Echinococcus granulosus | cpg binding protein | 0.0064 | 0.2263 | 0.2969 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0488 | 0.1682 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1299 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0183 | 0.703 | 0.8319 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0028 | 0.0794 | 0.2736 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.7442 | 0.7442 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.002 | 0.0488 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.105 | 0.7466 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0034 | 0.105 | 0.1242 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0028 | 0.0791 | 0.0791 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1279 | 0.9098 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.105 | 0.1242 |
Onchocerca volvulus | 0.0061 | 0.2124 | 1 | |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0028 | 0.0794 | 0.2736 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2263 | 0.2263 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.002 | 0.0497 | 0.0668 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0081 | 0.2943 | 0.3861 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.105 | 0.7466 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0008 | 0.001 | 0.001 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.002 | 0.0497 | 0.0668 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0008 | 0.001 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Entamoeba histolytica | Phosphatidylinositol 3- and 4-kinase family | 0.0011 | 0.0134 | 0.1031 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0183 | 0.703 | 0.8793 |
Brugia malayi | FAT domain containing protein | 0.0009 | 0.003 | 0.0041 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0.001 | 0.0071 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0008 | 0.001 | 0.0013 |
Brugia malayi | guanine nucleotide-binding protein G(o), alpha subunit, putative | 0.0008 | 0.001 | 0.0013 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0028 | 0.0794 | 0.0794 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0028 | 0.0794 | 0.2736 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0488 | 0.0655 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.004 | 0.1279 | 0.4411 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.214 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.105 | 0.105 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0488 | 0.0655 |
Schistosoma mansoni | GTP-binding protein (I) alpha subunit gnai | 0.0008 | 0.001 | 0.001 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0434 | 0.0569 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.5558 | 0.7467 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Onchocerca volvulus | 0.0008 | 0.001 | 0.0047 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1262 | 0.9714 |
Plasmodium vivax | glutathione reductase, putative | 0.008 | 0.29 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.214 | 0.2808 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.1406 | 0.4848 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.004 | 0.1279 | 0.3606 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Onchocerca volvulus | 0.0034 | 0.105 | 0.4942 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0218 | 0.845 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0034 | 0.105 | 0.1242 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Brugia malayi | glutathione reductase | 0.008 | 0.29 | 0.3897 |
Toxoplasma gondii | thioredoxin reductase | 0.008 | 0.29 | 0.6506 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1262 | 0.9865 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0488 | 0.1682 |
Loa Loa (eye worm) | beta-lactamase | 0.0034 | 0.105 | 0.141 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0028 | 0.0794 | 0.1066 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0008 | 0.001 | 0.0013 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.002 | 0.0488 | 0.3754 |
Mycobacterium ulcerans | hypothetical protein | 0.0034 | 0.105 | 0.1902 |
Brugia malayi | hypothetical protein | 0.004 | 0.1299 | 0.1745 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.002 | 0.0488 | 0.1682 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0013 | 0.0186 | 0.0418 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0028 | 0.0791 | 0.2726 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0028 | 0.0794 | 0.2736 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0489 | 0.1687 |
Toxoplasma gondii | FATC domain-containing protein | 0.0028 | 0.0791 | 0.1774 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.105 | 0.362 |
Brugia malayi | Guanine nucleotide-binding protein alpha-12 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0119 | 0.4457 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.1279 | 0.1678 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0034 | 0.105 | 0.1902 |
Echinococcus multilocularis | expressed protein | 0.0008 | 0.001 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0134 | 0.018 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0488 | 0.1682 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.002 | 0.0488 | 0.064 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1299 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0011 | 0.0134 | 0.0462 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.214 | 0.214 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.5558 | 0.7467 |
Mycobacterium ulcerans | beta-lactamase | 0.0034 | 0.105 | 0.1902 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2263 | 0.2263 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.002 | 0.0488 | 0.1682 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.1279 | 0.1678 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.1406 | 0.1844 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0635 | 0.2188 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.214 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0186 | 0.1325 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0027 | 0.0027 |
Entamoeba histolytica | protein kinase rad3, putative | 0.0011 | 0.0134 | 0.1031 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.002 | 0.0488 | 0.0488 |
Plasmodium falciparum | thioredoxin reductase | 0.008 | 0.29 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0008 | 0.001 | 0.001 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.1279 | 0.1719 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.008 | 0.29 | 0.3432 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0028 | 0.0791 | 0.1037 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0028 | 0.0794 | 0.1041 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0488 | 0.0655 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.7442 | 0.9764 |
Brugia malayi | Guanine nucleotide-binding protein alpha-6 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0008 | 0.001 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.003 | 0.003 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.003 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0186 | 0.025 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0203 | 0.785 | 0.9291 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0008 | 0.001 | 0.001 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0034 | 0.105 | 0.141 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0061 | 0.2124 | 0.2854 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0008 | 0.001 | 0.0013 |
Loa Loa (eye worm) | thioredoxin reductase | 0.008 | 0.29 | 0.3897 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.1406 | 0.3154 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0034 | 0.105 | 0.1242 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.7442 | 0.7442 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0011 | 0.0134 | 0.0176 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.7442 | 0.9764 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.7442 | 0.9764 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.7442 | 0.7442 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0203 | 0.785 | 0.9291 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1279 | 0.4411 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.5558 | 0.7291 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.002 | 0.0488 | 0.1682 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.1299 | 0.1299 |
Brugia malayi | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.002 | 0.0488 | 0.1682 |
Brugia malayi | guanine nucleotide-binding protein G-o protein alpha subunit | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0183 | 0.703 | 0.8319 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.008 | 0.29 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0008 | 0.001 | 0.001 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0008 | 0.001 | 0.001 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.0488 | 0.064 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.1406 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.5393 | 0.7075 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0028 | 0.0794 | 0.5644 |
Mycobacterium tuberculosis | Probable reductase | 0.0183 | 0.703 | 0.8319 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0034 | 0.105 | 0.7466 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.004 | 0.1279 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.105 | 0.105 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.002 | 0.0488 | 0.1682 |
Plasmodium falciparum | glutathione reductase | 0.0028 | 0.0794 | 0.2736 |
Onchocerca volvulus | 0.0034 | 0.105 | 0.4942 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1299 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.002 | 0.0488 | 0.3754 |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0008 | 0.001 | 0.0013 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0028 | 0.0791 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0183 | 0.703 | 0.8319 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.002 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.7622 | 0.7622 |
Echinococcus multilocularis | geminin | 0.0198 | 0.7622 | 1 |
Trichomonas vaginalis | GTP-binding protein (O) alpha subunit, gnao, putative | 0.0008 | 0.001 | 0.0071 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.1279 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1279 | 0.9098 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1279 | 0.1279 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.002 | 0.0488 | 0.1682 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.1279 | 0.9848 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.7442 | 0.9764 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0028 | 0.0794 | 0.0939 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0011 | 0.0134 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.0424 | 0.057 |
Loa Loa (eye worm) | G protein alpha subunit 3 | 0.0008 | 0.001 | 0.0013 |
Leishmania major | trypanothione reductase | 0.008 | 0.29 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0008 | 0.001 | 0.001 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0008 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.105 | 0.141 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0008 | 0.001 | 0.0013 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0488 | 0.1682 |
Treponema pallidum | NADH oxidase | 0.0028 | 0.0794 | 0.6204 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.003 | 0.0214 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0034 | 0.105 | 0.7466 |
Echinococcus multilocularis | PIK kinase, FAT and Armadillo domain containing protein | 0.0009 | 0.003 | 0.004 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0013 | 0.0186 | 0.1325 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0129 | 0.4868 | 0.4868 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0008 | 0.001 | 0.0013 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.105 | 0.141 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Echinococcus granulosus | PIK kinase FAT and Armadillo domain containing protein | 0.0009 | 0.003 | 0.004 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0791 | 0.5624 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0034 | 0.105 | 0.1242 |
Brugia malayi | guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.004 | 0.1279 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.1406 | 1 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-12 subunit | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0.001 | 0.0071 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.105 | 0.362 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Onchocerca volvulus | 0.0008 | 0.001 | 0.0047 | |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0028 | 0.0794 | 0.2736 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0203 | 0.785 | 0.9291 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0028 | 0.0794 | 0.2736 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Plasmodium vivax | thioredoxin reductase, putative | 0.008 | 0.29 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.105 | 0.1242 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.1299 | 0.1704 |
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0008 | 0.001 | 0.0013 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0028 | 0.0794 | 0.178 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1279 | 0.4411 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.004 | 0.1279 | 0.4411 |
Brugia malayi | Thioredoxin reductase | 0.008 | 0.29 | 0.3897 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.002 | 0.0488 | 0.064 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0193 | 0.7442 | 1 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0008 | 0.001 | 0.001 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0028 | 0.0794 | 0.5644 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0284 | 0.0373 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0193 | 0.7442 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1299 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0284 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.001 | 0.0013 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0028 | 0.0794 | 0.6204 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0008 | 0.001 | 0.0071 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0011 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.004 | 0.1279 | 0.1514 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1262 | 0.4351 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0134 | 0.0953 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0034 | 0.105 | 0.1377 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1279 | 0.4411 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1299 | 0.1299 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0013 | 0.0186 | 0.0642 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0489 | 0.1687 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Plasmodium falciparum | glutathione reductase | 0.008 | 0.29 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0635 | 0.0853 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0011 | 0.0134 | 0.0176 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0791 | 0.6087 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0034 | 0.105 | 0.362 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.7622 | 0.7622 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0028 | 0.0794 | 0.2736 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.214 | 0.214 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0034 | 0.105 | 0.141 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0231 | 0.1643 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0028 | 0.0794 | 0.2736 |
Toxoplasma gondii | ABC1 family protein | 0.0034 | 0.105 | 0.2355 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0034 | 0.105 | 0.1902 |
Echinococcus granulosus | expressed protein | 0.0008 | 0.001 | 0.0013 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0.001 | 0.0071 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1279 | 0.1279 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0231 | 0.1643 |
Trypanosoma brucei | trypanothione reductase | 0.008 | 0.29 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.002 | 0.0488 | 0.1682 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0488 | 0.3469 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.105 | 0.7466 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.533 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.477 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.412 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.239 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.213 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.148 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.079 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.