TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.397 | Formula: C23H18F2N2O3
H donors: 1 H acceptors: 3 LogP: 3.58 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1Oc2c(C1)c(ccn2)c1cccc(c1)C(=O)C)NCc1ccc(c(c1)F)F
InChi: 1S/C23H18F2N2O3/c1-13(28)15-3-2-4-16(10-15)17-7-8-26-23-18(17)11-21(30-23)22(29)27-12-14-5-6-19(24)20(25)9-14/h2-10,21H,11-12H2,1H3,(H,27,29)
InChiKey: NBHAUQWWONBQMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	photoreceptor-specific nuclear receptor	0.0157	0.3972	0.3972
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Schistosoma mansoni	thyroid hormone receptor	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Echinococcus granulosus	FTZ F1 alpha	0.0157	0.3972	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1646	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Brugia malayi	Steroid receptor seven-up type 2	0.0157	0.3972	0.3972
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0157	0.3972	0.3777
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0157	0.3972	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0157	0.3972	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1174	0.089
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0157	0.3972	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0074	0.1573	0.1573
Brugia malayi	Nuclear hormone receptor-like 1	0.0157	0.3972	0.3972
Brugia malayi	Nuclear hormone receptor-like 1	0.0083	0.183	0.183
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0083	0.183	0.3604
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0074	0.1573	0.2837
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0157	0.3972	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1646	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0157	0.3972	1
Loa Loa (eye worm)	steroid hormone receptor	0.0157	0.3972	0.3777
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0074	0.1573	0.1301
Schistosoma mansoni	nuclear receptor nhr-48	0.0074	0.1573	0.2837
Schistosoma mansoni	zinc finger protein	0.0074	0.1573	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Brugia malayi	hypothetical protein	0.0074	0.1573	0.1573
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1646	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0083	0.183	0.1566
Brugia malayi	nuclear hormone receptor	0.0074	0.1573	0.1573
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0157	0.3972	1
Schistosoma mansoni	coup transcription factor	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0623	0.0623
Schistosoma mansoni	nuclear hormone receptor	0.0074	0.1573	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Brugia malayi	nuclear hormone receptor	0.0157	0.3972	0.3972
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1646	0.3056
Schistosoma mansoni	retinoic acid receptor RXR	0.0157	0.3972	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1646	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0312	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0157	0.3972	0.3972
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0083	0.183	0.1566
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1646	0.0306
Brugia malayi	nuclear receptor RXR	0.0074	0.1573	0.1573
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0083	0.183	0.1071
Onchocerca volvulus	Bile acid receptor homolog	0.0157	0.3972	0.2847
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0157	0.3972	0.3777
Brugia malayi	Nuclear hormone receptor E75	0.0074	0.1573	0.1573
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0157	0.3972	0.3777
Brugia malayi	ecdysteroid receptor	0.0157	0.3972	0.3972
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0157	0.3972	0.3777
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0157	0.3972	0.3972
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0157	0.3972	0.3972
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0623	0.032
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0157	0.3972	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0312	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0157	0.3972	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1646	0.1646
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0157	0.3972	0.3972
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0157	0.3972	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0157	0.3972	0.3972
Onchocerca volvulus		0.0157	0.3972	0.2847
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0312	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0312	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0157	0.3972	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0083	0.183	0.183
Loa Loa (eye worm)	hypothetical protein	0.0083	0.183	0.1566
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0157	0.3972	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1646	0.1377
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0157	0.3972	1
Schistosoma mansoni	nuclear receptor	0.0074	0.1573	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1174	0.1174
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1174	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0083	0.183	0.1566
Schistosoma mansoni	thyroid hormone receptor	0.0157	0.3972	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0157	0.3972	0.3972
Onchocerca volvulus		0.0365	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0074	0.1573	0.2837
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1646	0.3056
Echinococcus multilocularis	ecdysone induced protein 78C	0.0157	0.3972	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0312	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0157	0.3972	1
Brugia malayi	hypothetical protein	0.003	0.0312	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0157	0.3972	0.3972
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0074	0.1573	0.1573
Schistosoma mansoni	RAR-like nuclear receptor	0.0157	0.3972	1
Brugia malayi	tailless protein	0.0074	0.1573	0.1573
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0157	0.3972	0.3972
Loa Loa (eye worm)	hypothetical protein	0.006	0.1174	0.089
Brugia malayi	ecdysone receptor	0.0074	0.1573	0.1573
Brugia malayi	nuclear receptor NHR-88	0.0157	0.3972	0.3972
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0083	0.183	0.3604
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0157	0.3972	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0083	0.183	0.1566
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0157	0.3972	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0157	0.3972	1
Loa Loa (eye worm)	DR-78	0.0074	0.1573	0.1301
Schistosoma mansoni	nuclear hormone receptor	0.0157	0.3972	1
Brugia malayi	steroid hormone receptor	0.0157	0.3972	0.3972
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1646	0.3056
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0074	0.1573	0.1301
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0074	0.1573	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0365	1	1
Brugia malayi	RNA binding protein	0.0076	0.1646	0.1646
Brugia malayi	orphan nuclear receptor NR2E1	0.0074	0.1573	0.1573
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1646	0.1377
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0157	0.3972	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0312	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0074	0.1573	0.1301
Brugia malayi	nuclear receptor RXR	0.0083	0.183	0.183
Echinococcus multilocularis	FTZ F1 alpha	0.0157	0.3972	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0157	0.3972	0.3972
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0312	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0157	0.3972	0.3777
Brugia malayi	nuclear receptor NHR-88	0.0074	0.1573	0.1573
Brugia malayi	Nuclear hormone receptor E75	0.0074	0.1573	0.1573
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0157	0.3972	0.3777
Onchocerca volvulus	Protein ultraspiracle homolog	0.0157	0.3972	0.2847
Brugia malayi	hypothetical protein	0.0083	0.183	0.183
Brugia malayi	hypothetical protein	0.0074	0.1573	0.1573
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3972	0.3777
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0157	0.3972	0.3972
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0157	0.3972	1
Brugia malayi	nuclear receptor NHR-67	0.0074	0.1573	0.1573
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0157	0.3972	0.3972
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0157	0.3972	0.3777
Brugia malayi	TAR-binding protein	0.0076	0.1646	0.1646
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0157	0.3972	0.3972
Schistosoma mansoni	nuclear receptor	0.0074	0.1573	0.2837
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0157	0.3972	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.183	0.1566
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0074	0.1573	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1573	0.1301
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0083	0.183	0.1071
Leishmania major	hypothetical protein, conserved	0.003	0.0312	0.5
Brugia malayi	conserved hypotetical protein	0.0074	0.1573	0.1573
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0157	0.3972	0.3972
Brugia malayi	hypothetical protein	0.0083	0.183	0.183
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0157	0.3972	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.2258 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.8022 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9582 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.8048 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1990183

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1648313