Detailed information for compound 1648652

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 508.47 | Formula: C22H19F3N4O5S
  • H donors: 2 H acceptors: 6 LogP: 5.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCOC(=O)c1ccc(o1)c1ccc2c(c1)c(ncn2)NCc1csc(n1)C
  • InChi: 1S/C20H18N4O3S.C2HF3O2/c1-3-26-20(25)18-7-6-17(27-18)13-4-5-16-15(8-13)19(23-11-22-16)21-9-14-10-28-12(2)24-14;3-2(4,5)1(6)7/h4-8,10-11H,3,9H2,1-2H3,(H,21,22,23);(H,6,7)
  • InChiKey: UKCALWNCLPWCIB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0026 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.1018 0.5
Schistosoma mansoni hypothetical protein 0.0026 1 1
Schistosoma mansoni ryanodine receptor related 0.0026 1 1
Brugia malayi Cytochrome P450 family protein 0.002 0.632 0.5903
Leishmania major cytochrome p450-like protein 0.002 0.632 0.5903
Loa Loa (eye worm) voltage-gated potassium channel 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0026 1 1
Trypanosoma brucei cytochrome P450, putative 0.002 0.632 0.5903
Schistosoma mansoni transient receptor potential channel 0.0026 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0026 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.1018 0.5
Toxoplasma gondii hypothetical protein 0.0026 1 1
Brugia malayi voltage-dependent calcium channel 0.0026 1 1
Echinococcus granulosus calcium activated potassium channel 0.0026 1 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0026 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 1 1
Echinococcus multilocularis calcium activated potassium channel 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 1 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0026 1 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0026 1 1
Echinococcus granulosus potassium large conductance calcium activated 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0026 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 1 1
Echinococcus granulosus ryanodine receptor 44f 0.0026 1 1
Echinococcus multilocularis ryanodine receptor 44f 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.1018 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.1018 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0026 1 1
Echinococcus multilocularis sodium channel protein 0.0026 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0026 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0026 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0026 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.1018 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0026 1 1
Schistosoma mansoni voltage-gated ion channel 0.0026 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 1 1
Toxoplasma gondii hypothetical protein 0.0026 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0026 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 1 0.5
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 1 1
Leishmania major hypothetical protein, conserved 0.0026 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.1018 0.5
Schistosoma mansoni transient receptor potential channel 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0026 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0026 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.1018 0.1018
Echinococcus granulosus voltage gated potassium channel 0.0026 1 1
Brugia malayi hypothetical protein 0.0026 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.632 0.632
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0026 1 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0026 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0026 1 1
Echinococcus granulosus sodium channel protein 0.0026 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0026 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus multilocularis shaker cognate 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0026 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0026 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 1 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0026 1 1
Leishmania major hypothetical protein, unknown function 0.0026 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0026 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0026 1 1
Brugia malayi Cytochrome P450 family protein 0.002 0.632 0.5903
Toxoplasma gondii transporter, cation channel family protein 0.0026 1 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0026 1 1
Echinococcus granulosus sodium leak channel non selective protein 0.0026 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.1018 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.632 0.5903
Echinococcus granulosus shaker cognate 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 1 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0026 1 1
Loa Loa (eye worm) ion channel NompC 0.0026 1 1
Schistosoma mansoni voltage-gated cation channel 0.0026 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0026 1 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0026 1 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.1018 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 1 1
Loa Loa (eye worm) ryanodine receptor 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.1018 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0026 1 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.1018 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Brugia malayi cation channel family protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Brugia malayi Transient-receptor-potential like protein 0.0026 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0026 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.1018 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 1 0.5
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 1 1
Echinococcus granulosus voltage gated potassium channel 0.0026 1 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus granulosus two pore calcium channel protein 1 0.0026 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0026 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0026 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 1 1
Schistosoma mansoni voltage-dependent calcium channel 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0026 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0026 1 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.632 0.5903
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.1018 0.5
Brugia malayi ion channel NompC 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.1018 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Schistosoma mansoni 60S ribosomal protein L21 0.0026 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 1 1
Loa Loa (eye worm) CYP4Cod1 0.002 0.632 0.632
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0026 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 1 1
Loa Loa (eye worm) cytochrome P450 0.0011 0.1018 0.1018
Loa Loa (eye worm) calcium channel 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0026 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0026 1 1
Onchocerca volvulus 0.0026 1 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.1018 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0026 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0026 1 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0026 1 1
Schistosoma mansoni transient receptor potential channel 0.0026 1 1
Echinococcus multilocularis transfer RNA-Gly 0.0026 1 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0026 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.1018 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.632 0.632
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0026 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0026 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0026 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.632 1
Echinococcus granulosus two pore calcium channel protein 2 0.0026 1 1
Schistosoma mansoni vesicular amine transporter 0.0026 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.1018 0.5
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.1018 0.5
Echinococcus granulosus transient receptor potential gamma protein 0.0026 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0026 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0026 1 1
Schistosoma mansoni two-pore calcium channel 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.1018 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Mycobacterium leprae putative cytochrome p450 0.0011 0.1018 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0026 1 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.1018 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.1018 0.5
Brugia malayi cation channel family protein 0.0026 1 1
Echinococcus granulosus hypothetical protein 0.0026 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0026 1 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0026 1 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.1018 0.5
Schistosoma mansoni calcium-activated potassium channel 0.0026 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0026 1 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0026 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0026 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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