Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.3196 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0356 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4676 | 1 |
Brugia malayi | RNA binding protein | 0.0135 | 0.3196 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3196 | 0.6836 |
Onchocerca volvulus | 0.0052 | 0.0634 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4676 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0103 | 0.2211 | 0.2211 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0204 | 0.0204 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.3196 | 0.3196 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0634 | 0.1357 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3196 | 0.6836 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.0381 | 0.0381 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0204 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0164 | 0.0351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3196 | 0.6836 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.2905 | 0.9088 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0164 | 0.0513 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.3196 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3196 | 0.6836 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0204 | 0.0204 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0164 | 0.0513 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.069 | 0.2158 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.2905 | 0.9088 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0204 | 0.0437 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0183 | 0.4676 | 0.4676 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.3196 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0634 | 0.1984 |
Schistosoma mansoni | jumonji domain containing protein | 0.0082 | 0.1557 | 0.3329 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.069 | 0.2158 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.3196 | 0.6836 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0204 | 0.0437 |
Brugia malayi | jmjC domain containing protein | 0.0103 | 0.2211 | 0.6916 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.3196 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.0381 | 0.0381 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0103 | 0.2211 | 0.2211 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.3196 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0204 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0694 | 0.2172 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0183 | 0.4676 | 0.4676 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.069 | 0.2158 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.069 | 0.2158 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.3196 | 0.3196 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0065 | 0.1035 | 0.3237 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.2905 | 0.9088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.