Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0036 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0477 | 0.061 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0333 | 0.0426 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0477 | 0.1457 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.7822 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0036 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0036 | 0.0046 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.0036 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0333 | 0.0426 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0341 | 1 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0167 | 0.4166 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0036 | 0.0046 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.3276 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0167 | 0.4166 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0333 | 0.0426 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.3276 | 0.4187 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.3276 | 0.4187 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.3276 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0036 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.3276 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0333 | 0.0426 |
Brugia malayi | RNA binding protein | 0.014 | 0.3276 | 0.4187 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0477 | 0.1457 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0036 | 1 |
Brugia malayi | TAR-binding protein | 0.014 | 0.3276 | 0.4187 |
Brugia malayi | hypothetical protein | 0.0276 | 0.7822 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.3276 | 0.4187 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.3276 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0341 | 1 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0036 | 0.0036 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0036 | 0.0046 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0167 | 0.4166 | 0.5503 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0036 | 0.0046 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 0.3276 | 0.4187 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0036 | 0.0036 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0036 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.3276 | 0.4187 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.7822 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0036 | 0.0111 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.7822 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 0.3276 | 0.4187 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.3276 | 1 |
Onchocerca volvulus | 0.0056 | 0.0477 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.7571 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0036 | 0.0111 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0036 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.503 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.353 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.982 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.901 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.766 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.755 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.744 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.624 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.621 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.