Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Kynurenine 3-monooxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | potential monooxygenase similar to S. cerevisiae BNA4 (YBL098W) kynurenine 3-monooxygenase, biosynthesis of Nicotinic Acid | Get druggable targets OG5_129812 | All targets in OG5_129812 |
Candida albicans | potential monooxygenase similar to S. cerevisiae BNA4 (YBL098W) kynurenine 3-monooxygenase, biosynthesis of Nicotinic Acid | Get druggable targets OG5_129812 | All targets in OG5_129812 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.1076 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0603 | 0.5268 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0603 | 0.5268 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0603 | 0.5268 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0603 | 0.5268 | 0.5491 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0077 | 0 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0603 | 0.5268 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0349 | 0.2725 | 0.2725 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0603 | 0.5268 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0603 | 0.5268 | 0.5268 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1036 | 0.9594 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0603 | 0.5268 | 0.5 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0603 | 0.5268 | 0.5268 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0077 | 0 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0603 | 0.5268 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0349 | 0.2725 | 0.2841 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.48 uM | Inhibition of rat brain KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 0.48 uM | Inhibition of rat brain KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 1.1 uM | Inhibition of rat liver KYN 3-OHase. | ChEMBL. | 9873646 |
IC50 (binding) | = 1.1 uM | Inhibition of rat liver KYN 3-OHase. | ChEMBL. | 9873646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.