Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 0.9591 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 0.9591 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0155 | 0.3077 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0136 | 0.2372 | 0.056 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3077 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0136 | 0.2372 | 0.056 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0136 | 0.2372 | 0.2473 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 0.9591 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2688 | 0.2803 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3077 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.033 | 0.9591 | 0.9504 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.2372 | 0.2473 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 0.9591 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1757 | 0.1832 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.9591 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 0.9591 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.7312 | 0.7623 |
Brugia malayi | CHE-14 protein | 0.0136 | 0.2372 | 0.0746 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3077 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.033 | 0.9591 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.033 | 0.9591 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 0.9591 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1757 | 0.1832 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 nM | Tested in vivo for hypocholesterolemic activity by measuring its ability to decrease serum total cholesterol, after oral administration of 75 mg/kg body wt. per day in normolipemic NZW rabbits; Not significantly active | ChEMBL. | 1656041 |
IC50 (binding) | = 400 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (binding) | = 400 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (functional) | > 500 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (functional) | > 500 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
Relative potency (binding) | = 2 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (functional) | < 10 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 2 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (functional) | < 10 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.