Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.0378 | 0.06 |
Onchocerca volvulus | Alhambra homolog | 0.0033 | 0.0258 | 0.0046 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.012 | 0.376 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0056 | 0.0551 | 0.1278 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0144 | 0.0273 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0107 | 0.1201 | 0.201 |
Mycobacterium tuberculosis | Probable reductase | 0.0096 | 0.1064 | 0.1776 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.1633 | 0.3765 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0293 | 0.1146 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.0551 | 0.1278 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0273 | 0.0629 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0253 | 0.0253 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.0785 | 0.1822 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.012 | 0.012 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.3625 | 0.8439 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.0378 | 0.0874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0175 | 0.092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.2294 | 0.2294 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0107 | 0.1201 | 0.201 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.0295 | 0.0627 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.3625 | 0.8439 |
Onchocerca volvulus | 0.0048 | 0.0446 | 0.3606 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0107 | 0.1204 | 0.1301 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1633 | 0.3765 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.1835 | 0.3097 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0126 | 0.1437 | 0.3305 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.0785 | 0.1775 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0051 | 0.0487 | 0.1076 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0785 | 0.4728 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0087 | 0.0949 | 0.1025 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.1633 | 0.3765 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0351 | 0.4291 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0051 | 0.0487 | 0.0526 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.0034 | 0.0014 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0253 | 0.0244 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0374 | 0.0812 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0273 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.0378 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0293 | 0.0287 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0249 | 0.3003 | 0.7106 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0785 | 0.1297 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0188 | 0.2233 | 0.5203 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0144 | 0.0144 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0785 | 0.4728 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.4226 | 0.4549 |
Schistosoma mansoni | ran | 0.0024 | 0.0144 | 0.0126 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.0378 | 0.0874 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.0034 | 0.0014 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.0378 | 0.0821 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0051 | 0.0487 | 0.1131 |
Onchocerca volvulus | 0.0074 | 0.0785 | 1 | |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0253 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0487 | 0.1148 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.012 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0949 | 0.0998 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.0785 | 0.1775 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0042 | 0.0369 | 0.087 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.012 | 0.0158 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0175 | 0.0346 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.0378 | 0.0874 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0949 | 0.0998 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.3397 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0025 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.334 | 0.7903 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0175 | 0.092 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0141 | 0.1629 | 0.176 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0421 | 0.0421 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0034 | 0.0273 | 0.0575 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0107 | 0.1201 | 0.201 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0024 | 0.0144 | 0.0273 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.1545 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0551 | 0.1301 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0137 | 0.1579 | 0.9692 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.2294 | 0.2479 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.0785 | 0.1775 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0785 | 0.1775 |
Brugia malayi | hypothetical protein | 0.0233 | 0.2804 | 0.6535 |
Echinococcus multilocularis | dna polymerase eta | 0.0051 | 0.0487 | 0.0487 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0785 | 0.082 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8729 |
Schistosoma mansoni | hypothetical protein | 0.0742 | 0.9255 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.0378 | 0.0877 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0096 | 0.1064 | 0.1776 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0949 | 0.0998 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.012 | 0.012 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.0378 | 0.0821 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8729 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.0551 | 0.1228 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.0258 | 0.0279 |
Entamoeba histolytica | Ran family GTPase | 0.0024 | 0.0144 | 0.0162 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0141 | 0.1629 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0785 | 0.1775 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0258 | 0.0249 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.0258 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.2804 | 0.6635 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0279 | 0.0279 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0141 | 0.1629 | 0.176 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0087 | 0.0949 | 0.0949 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0087 | 0.0949 | 0.1025 |
Brugia malayi | glutathione reductase | 0.0042 | 0.0378 | 0.0877 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0141 | 0.1629 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0249 | 0.3003 | 0.6998 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.0785 | 0.1775 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.1545 | 0.3598 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.0551 | 0.1228 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0141 | 0.1629 | 0.1629 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.0551 | 0.1278 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0351 | 0.4291 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.3397 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.3625 | 0.8439 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0785 | 0.1775 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0293 | 0.1146 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.012 | 0.028 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0069 | 0.0719 | 0.0749 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0785 | 0.1825 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.0295 | 0.0627 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0785 | 0.1854 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.1437 | 0.3305 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0785 | 0.4728 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0785 | 0.1825 |
Leishmania major | DNA polymerase eta, putative | 0.0051 | 0.0487 | 0.1076 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.2233 | 0.239 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0034 | 0.0273 | 0.1014 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0293 | 0.0293 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0096 | 0.1064 | 0.1776 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0785 | 0.4728 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0452 | 0.0996 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.0258 | 0.0258 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8729 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.012 | 0.0216 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.0258 | 0.0258 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.004 | 0.0346 | 0.0346 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0021 | 0.0104 | 0.0239 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0351 | 0.4291 | 0.7305 |
Echinococcus granulosus | geminin | 0.0742 | 0.9255 | 1 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0551 | 0.1281 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.0785 | 0.1297 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.012 | 0.0576 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.012 | 0.013 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0374 | 0.0812 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0273 | 0.0629 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0144 | 0.0338 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0141 | 0.1629 | 0.1629 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.3305 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0175 | 0.0365 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.0295 | 0.0627 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.0258 | 0.0249 |
Plasmodium falciparum | glutathione reductase | 0.0015 | 0.0028 | 0.0057 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.0785 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0034 | 0.0273 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0949 | 0.2242 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0137 | 0.1579 | 0.9692 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0258 | 0.0594 |
Echinococcus multilocularis | snurportin 1 | 0.0345 | 0.4226 | 0.4226 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0087 | 0.0949 | 0.2208 |
Echinococcus granulosus | peregrin | 0.0033 | 0.0258 | 0.0279 |
Echinococcus multilocularis | GPCR, family 2 | 0.0087 | 0.0949 | 0.0949 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0015 | 0.0028 | 0.0057 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0421 | 0.0455 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.016 | 0.0143 |
Leishmania major | trypanothione reductase | 0.0042 | 0.0378 | 0.0821 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0374 | 0.0812 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.0785 | 0.1297 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0043 | 0.0385 | 0.0385 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0015 | 0.0028 | 0.0057 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0374 | 0.0812 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0015 | 0.0028 | 0.003 |
Schistosoma mansoni | DNA polymerase eta | 0.0051 | 0.0487 | 0.0497 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.0034 | 0.0014 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0096 | 0.1064 | 0.1776 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0137 | 0.1579 | 0.9692 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.3346 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0253 | 0.0582 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.0034 | 0.0014 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.0551 | 0.1228 |
Echinococcus multilocularis | geminin | 0.0742 | 0.9255 | 0.9255 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0042 | 0.0369 | 0.037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.2294 | 0.2479 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.012 | 0.0216 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0701 | 0.1655 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0555 | 0.131 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0126 | 0.1437 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0144 | 0.0156 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.0625 | 0.1402 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0126 | 0.1437 | 0.186 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0024 | 0.0144 | 0.0329 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0015 | 0.0028 | 0.0028 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.0258 | 0.939 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.2294 | 0.2456 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0107 | 0.1201 | 0.1187 |
Echinococcus granulosus | GPCR family 2 | 0.0087 | 0.0949 | 0.1025 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0015 | 0.0028 | 0.0057 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0019 | 0.0081 | 0.0057 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.012 | 0.0276 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.2804 | 0.303 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0785 | 0.1775 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0144 | 0.0273 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0785 | 0.082 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0279 | 0.0302 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0785 | 0.4728 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.012 | 0.0216 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0276 | 0.334 | 0.7903 |
Leishmania major | GTP-binding protein, putative | 0.0024 | 0.0144 | 0.0273 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0051 | 0.0487 | 0.1076 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0144 | 0.0273 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0253 | 0.0528 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.012 | 0.0216 |
Schistosoma mansoni | jumonji domain containing protein | 0.0085 | 0.0924 | 0.0971 |
Onchocerca volvulus | 0.0074 | 0.0785 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.2804 | 0.2804 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0446 | 0.1037 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0144 | 0.0329 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.0785 | 0.1297 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0042 | 0.0369 | 0.0399 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0253 | 0.0585 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.0258 | 0.0594 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0785 | 0.1297 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0256 | 0.0601 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0141 | 0.1629 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0351 | 0.4291 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.0785 | 0.4728 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0096 | 0.1064 | 0.1776 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.0785 | 0.1297 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0258 | 0.054 |
Onchocerca volvulus | 0.0074 | 0.0785 | 1 | |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.012 | 0.0576 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0785 | 0.1854 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.0378 | 0.0891 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.0258 | 0.0607 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.2294 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0785 | 0.1854 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0273 | 0.1531 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8802 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0258 | 0.054 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0785 | 0.1825 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0351 | 0.4291 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0273 | 0.0629 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0256 | 0.0592 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.012 | 0.0216 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0351 | 0.4291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0258 | 0.0607 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.0034 | 0.0014 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.1527 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.0785 | 0.1297 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0253 | 0.0528 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.1527 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8802 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0949 | 0.0998 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.0258 | 0.0598 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0175 | 0.0346 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0107 | 0.1204 | 0.1204 |
Plasmodium falciparum | thioredoxin reductase | 0.0015 | 0.0028 | 0.0057 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0096 | 0.1064 | 0.0798 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.1835 | 0.4239 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0087 | 0.0949 | 0.0949 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.2294 | 0.2294 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.012 | 0.013 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0475 | 0.5863 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0293 | 0.1146 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0351 | 0.4291 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0175 | 0.092 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0253 | 0.0595 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0351 | 0.4291 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0137 | 0.1579 | 0.3678 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0087 | 0.0949 | 0.2208 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0351 | 0.4291 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.03 | 0.0695 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0126 | 0.1437 | 0.2414 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0351 | 0.4291 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8802 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.3625 | 0.8439 |
Schistosoma mansoni | hypothetical protein | 0.0742 | 0.9255 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0293 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.2233 | 0.5283 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.1545 | 0.3654 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0126 | 0.1437 | 0.1437 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0276 | 0.334 | 0.7783 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0087 | 0.0949 | 0.2242 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0293 | 0.1146 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.2294 | 0.2456 |
Trichomonas vaginalis | ran, putative | 0.0024 | 0.0144 | 0.0728 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0137 | 0.1579 | 0.3639 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0446 | 0.0454 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0253 | 0.0528 |
Schistosoma mansoni | ran | 0.0024 | 0.0144 | 0.0126 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.0378 | 0.0891 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0042 | 0.0369 | 0.037 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0273 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0351 | 0.4291 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0126 | 0.1437 | 0.3397 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.0785 | 0.1297 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0193 | 0.2294 | 0.5427 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0785 | 0.1297 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0253 | 0.0273 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0144 | 0.4754 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.0378 | 0.0821 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0015 | 0.0028 | 0.0057 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0144 | 0.0333 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0351 | 0.4291 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.0785 | 0.1775 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0056 | 0.0551 | 0.1228 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0293 | 0.0316 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.1437 | 0.3346 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.101 | 0.2351 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0491 | 0.1085 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0446 | 0.0454 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.012 | 0.0216 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0351 | 0.4291 | 0.462 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0279 | 0.0272 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0351 | 0.4291 | 1 |
Brugia malayi | phosphofructokinase | 0.0126 | 0.1437 | 0.3346 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.1437 | 0.8802 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0034 | 0.0273 | 0.174 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0351 | 0.4291 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0034 | 0.0273 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0025 | 0.016 | 0.0173 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.0785 | 0.1775 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0056 | 0.0551 | 0.1228 |
Brugia malayi | jmjC domain containing protein | 0.0107 | 0.1204 | 0.2804 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0126 | 0.1437 | 0.1552 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0273 | 0.0629 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0015 | 0.0028 | 0.0061 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0293 | 0.0287 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.012 | 0.0216 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0193 | 0.2294 | 0.5344 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0345 | 0.4226 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0256 | 0.0247 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.012 | 0.0158 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.012 | 0.01 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0034 | 0.0273 | 0.0575 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0276 | 0.334 | 0.7783 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0785 | 0.0785 |
Echinococcus granulosus | snurportin 1 | 0.0345 | 0.4226 | 0.4566 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0785 | 0.0848 |
Brugia malayi | jmjC domain containing protein | 0.0042 | 0.0369 | 0.0857 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0137 | 0.1579 | 0.9692 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0279 | 0.0272 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0096 | 0.1064 | 0.1776 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0785 | 0.1825 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0043 | 0.0385 | 0.0416 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.1437 | 0.3305 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Effect on SOD2 gene expression in Saccharomyces cerevisiae K6001 at 10 uM by RT-PCR | ChEMBL. | 20093034 | |
Activity (functional) | Antiaging effect in Saccharomyces cerevisiae K6001 assessed as extension of replicative life span at 10 uM after 2 days | ChEMBL. | 20093034 | |
Activity (functional) | Effect on SIRT1 expression in Saccharomyces cerevisiae K6001 by SIRT1/Sir2 deacetylase fluorometric assay | ChEMBL. | 20093034 | |
Activity (functional) | Antiaging effect in Saccharomyces cerevisiae K6001 expressing skn7 mutant assessed as extension of replicative life span after 2 days | ChEMBL. | 20093034 | |
Activity (functional) | Effect on SOD1 gene expression in Saccharomyces cerevisiae K6001 at 10 uM by RT-PCR | ChEMBL. | 20093034 | |
Activity (functional) | Antiaging effect in Saccharomyces cerevisiae K6001 expressing uth1 mutant assessed as extension of replicative life span after 2 days | ChEMBL. | 20093034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.