Detailed information for compound 1649911

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.616 | Formula: C28H40O2
  • H donors: 1 H acceptors: 2 LogP: 5.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@H](/C=C/[C@H]([C@H]1C[C@H](C2=C3C(CC[C@]12C)[C@@]1(C)CCC(=O)C=C1C=C3)O)C)C)C
  • InChi: 1S/C28H40O2/c1-17(2)18(3)7-8-19(4)24-16-25(30)26-22-10-9-20-15-21(29)11-13-27(20,5)23(22)12-14-28(24,26)6/h7-10,15,17-19,23-25,30H,11-14,16H2,1-6H3/b8-7+/t18-,19+,23?,24+,25+,27-,28+/m0/s1
  • InChiKey: MMVSNLKSAHIETF-APORJJJJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0378 0.06
Schistosoma mansoni hypothetical protein 0.0188 0.2233 0.239
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0785 0.4728
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0785 0.0785
Schistosoma mansoni importin beta-1 0.0032 0.0253 0.0244
Giardia lamblia PHD finger protein 15 0.0033 0.0258 0.939
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0141 0.1629 0.176
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.4226 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.0351 0.4291 0.462
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0378 0.0891
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0785 0.1297
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1437 0.8802
Onchocerca volvulus Alhambra homolog 0.0033 0.0258 0.0046
Mycobacterium ulcerans hypothetical protein 0.0074 0.0785 0.1775
Brugia malayi hypothetical protein 0.0036 0.03 0.0695
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0351 0.4291 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1204 0.1204
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0551 0.1228
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0785 0.082
Mycobacterium ulcerans hypothetical protein 0.0157 0.1835 0.4239
Brugia malayi Thioredoxin reductase 0.0042 0.0378 0.0877
Trypanosoma brucei unspecified product 0.0015 0.0034 0.0014
Echinococcus multilocularis cpg binding protein 0.0034 0.0279 0.0279
Echinococcus granulosus dna polymerase kappa 0.0022 0.012 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2294 0.2479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0949 0.0949
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0374 0.0812
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.012 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0785 0.1775
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.3625 0.8439
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0258 0.0279
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.012 0.0576
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0141 0.1629 1
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0369 0.0399
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0551 0.1228
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1437 0.8729
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0351 0.4291 1
Brugia malayi 6-phosphofructokinase 0.0126 0.1437 0.3346
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0273 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0785 0.1775
Plasmodium falciparum glutathione reductase 0.0042 0.0378 0.0874
Echinococcus granulosus geminin 0.0742 0.9255 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0293 0.0287
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1437 0.3305
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0333
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0273 0.1014
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1437 0.1437
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1204 0.1301
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0273 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2294 0.2456
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0137 0.1579 0.9692
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0273 0.174
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.012 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0028 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0949 0.2208
Brugia malayi Calcitonin receptor-like protein seb-1 0.0276 0.334 0.7783
Plasmodium falciparum importin beta, putative 0.0032 0.0253 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0188 0.2233 0.5203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.012 0.0158
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0249
Brugia malayi beta-lactamase family protein 0.0074 0.0785 0.1825
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0273 0.0629
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.012 0.012
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0137 0.1579 0.9692
Onchocerca volvulus 0.0074 0.0785 1
Brugia malayi hypothetical protein 0.0056 0.0551 0.1281
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1437 0.1552
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0785 0.1297
Leishmania major DNA polymerase kappa, putative 0.0022 0.012 0.0216
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.1201 0.201
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1437 0.2414
Schistosoma mansoni hypothetical protein 0.0048 0.0446 0.0454
Schistosoma mansoni cpg binding protein 0.0034 0.0279 0.0272
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0785 0.4728
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2294 0.2456
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0273 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0034 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1437 0.8729
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0175 0.092
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2804 0.303
Toxoplasma gondii thioredoxin reductase 0.0042 0.0378 0.0821
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0351 0.4291 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0144 0.0329
Loa Loa (eye worm) hypothetical protein 0.0051 0.0487 0.1148
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.0273
Brugia malayi 6-phosphofructokinase 0.0126 0.1437 0.3346
Brugia malayi jmjC domain containing protein 0.0042 0.0369 0.0857
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0351 0.4291 0.7305
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0487 0.1076
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1835 0.3097
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0421 0.0421
Mycobacterium tuberculosis Conserved protein 0.0074 0.0785 0.1297
Schistosoma mansoni hypothetical protein 0.0345 0.4226 0.4549
Brugia malayi glutathione reductase 0.0042 0.0378 0.0877
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0785 0.1775
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1437 0.3397
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0487 0.1076
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3625 0.8439
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0351 0.4291 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0785 0.1775
Onchocerca volvulus 0.0074 0.0785 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0273 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.1201 0.201
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1437 0.3305
Schistosoma mansoni hypothetical protein 0.0087 0.0949 0.0998
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.012 0.0216
Loa Loa (eye worm) hypothetical protein 0.0032 0.0253 0.0595
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Brugia malayi Bromodomain containing protein 0.0033 0.0258 0.0598
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1437 0.3305
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0247
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0141 0.1629 0.1629
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1437 0.1527
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.012 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0276 0.334 0.7783
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.016 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0785 0.082
Echinococcus multilocularis GPCR, family 2 0.0087 0.0949 0.0949
Brugia malayi hypothetical protein 0.0233 0.2804 0.6535
Brugia malayi follicle stimulating hormone receptor 0.0249 0.3003 0.6998
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0924 0.0971
Plasmodium vivax glutathione reductase, putative 0.0042 0.0378 0.0874
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.1064 0.1776
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.1146
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Brugia malayi phosphofructokinase 0.0126 0.1437 0.3346
Echinococcus granulosus peregrin 0.0033 0.0258 0.0279
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.012 0.013
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1437 0.8729
Leishmania major hypothetical protein, conserved 0.0056 0.0551 0.1228
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0137 0.1579 0.9692
Mycobacterium tuberculosis Conserved protein 0.0074 0.0785 0.1297
Plasmodium falciparum thioredoxin reductase 0.0015 0.0028 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.012 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0719 0.0749
Schistosoma mansoni hypothetical protein 0.0742 0.9255 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0785 0.1854
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0487 0.1131
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0551 0.1278
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0253 0.0528
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0785 0.1297
Loa Loa (eye worm) hypothetical protein 0.0056 0.0551 0.1301
Schistosoma mansoni hypothetical protein 0.0087 0.0949 0.0998
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.3003 0.7106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0625 0.1402
Leishmania major GTP-binding protein, putative 0.0024 0.0144 0.0273
Loa Loa (eye worm) glutathione reductase 0.0042 0.0378 0.0891
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0607
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0551 0.1278
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0551 0.1278
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3625 0.8439
Schistosoma mansoni cpg binding protein 0.0034 0.0279 0.0272
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0785 0.1822
Entamoeba histolytica hypothetical protein 0.0026 0.0175 0.0365
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0137 0.1579 0.3639
Trypanosoma brucei unspecified product 0.0015 0.0034 0.0014
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1437 0.3305
Brugia malayi RNA, U transporter 1 0.0092 0.101 0.2351
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0785 0.1297
Schistosoma mansoni hypothetical protein 0.0025 0.016 0.0143
Brugia malayi hypothetical protein 0.0036 0.0293 0.0679
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0374 0.0812
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0258 0.0607
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.012 0.0216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0949 0.0949
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.1064 0.1776
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0276 0.334 0.7903
Mycobacterium ulcerans beta-lactamase 0.0074 0.0785 0.1775
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0175 0.092
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0491 0.1085
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0351 0.4291 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0273 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.012 0.0216
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0273 0.0629
Schistosoma mansoni hypothetical protein 0.0742 0.9255 1
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0421 0.0455
Schistosoma mansoni hypothetical protein 0.0087 0.0949 0.0998
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0351 0.4291 1
Echinococcus multilocularis dna polymerase kappa 0.0022 0.012 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.0273
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.1064 0.1776
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0551 0.1228
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0785 0.1775
Brugia malayi Importin beta-1 subunit 0.0032 0.0253 0.0585
Loa Loa (eye worm) beta-lactamase 0.0074 0.0785 0.1854
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0253 0.0528
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0273 0.1531
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0378 0.0874
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1633 0.3765
Echinococcus multilocularis geminin 0.0742 0.9255 0.9255
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0378 0.0821
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1437 0.3397
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0028 0.0057
Plasmodium falciparum glutathione reductase 0.0015 0.0028 0.0057
Leishmania major DNA polymerase eta, putative 0.0036 0.0295 0.0627
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0028 0.003
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0351 0.4291 1
Schistosoma mansoni ran 0.0024 0.0144 0.0126
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.012 0.01
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1437 0.186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2294 0.2456
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0137 0.1579 0.9692
Schistosoma mansoni DNA polymerase eta 0.0051 0.0487 0.0497
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0385 0.0416
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0785 0.1825
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0258 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.1146
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.012 0.0216
Trypanosoma brucei trypanothione reductase 0.0042 0.0378 0.0821
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0144 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.012 0.028
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0295 0.0627
Echinococcus granulosus snurportin 1 0.0345 0.4226 0.4566
Loa Loa (eye worm) hypothetical protein 0.0233 0.2804 0.6635
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1545 0.3654
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.012 0.0158
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0175 0.0346
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.016 0.016
Echinococcus multilocularis snurportin 1 0.0345 0.4226 0.4226
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0253 0.0528
Echinococcus granulosus GPCR family 2 0.0087 0.0949 0.1025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.1064 0.1776
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0351 0.4291 1
Onchocerca volvulus 0.0048 0.0446 0.3606
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0785 0.4728
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0258 0.0249
Brugia malayi CXXC zinc finger family protein 0.0033 0.0256 0.0592
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0351 0.4291 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2294 0.2479
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.1201 0.201
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1437 1
Plasmodium falciparum thioredoxin reductase 0.0042 0.0378 0.0874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2294 0.2294
Brugia malayi Zinc finger, C2H2 type family protein 0.0137 0.1579 0.3678
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0028 0.0061
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0028 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0295 0.0627
Schistosoma mansoni ran 0.0024 0.0144 0.0126
Loa Loa (eye worm) hypothetical protein 0.0056 0.0555 0.131
Echinococcus granulosus importin subunit beta 1 0.0032 0.0253 0.0273
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Echinococcus multilocularis dna polymerase eta 0.0051 0.0487 0.0487
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0258 0.054
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1437 0.1527
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.012 0.0576
Leishmania major dihydroorotate dehydrogenase 0.0351 0.4291 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0785 0.1297
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0785 0.1297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.012 0.0216
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0385 0.0385
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.4754
Schistosoma mansoni hypothetical protein 0.0087 0.0949 0.0998
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0273 0.0629
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0256 0.0601
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1437 0.8802
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0028 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0949 0.2208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0369 0.037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.1064 0.0798
Onchocerca volvulus 0.0074 0.0785 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.012 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0369 0.087
Brugia malayi jmjC domain containing protein 0.0107 0.1204 0.2804
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0141 0.1629 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0141 0.1629 0.1629
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0701 0.1655
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0785 0.4728
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0253 0.0253
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1437 0.3397
Trypanosoma brucei unspecified product 0.0022 0.012 0.0216
Toxoplasma gondii ABC1 family protein 0.0074 0.0785 0.1775
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0144 0.0156
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0273 0.0575
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0104 0.0239
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1437 0.8802
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0369 0.037
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0141 0.1629 0.176
Schistosoma mansoni survival motor neuron protein 0.0048 0.0446 0.0454
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.3625 0.8439
Mycobacterium tuberculosis Probable reductase 0.0096 0.1064 0.1776
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0293 0.0316
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.012 0.0276
Giardia lamblia DINP protein human, muc B family 0.0022 0.012 0.376
Echinococcus granulosus dna polymerase eta 0.0051 0.0487 0.0526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0081 0.0057
Leishmania major DNA polymerase eta, putative 0.0051 0.0487 0.1076
Loa Loa (eye worm) hypothetical protein 0.0276 0.334 0.7903
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Echinococcus granulosus cpg binding protein 0.0034 0.0279 0.0302
Brugia malayi beta-lactamase 0.0074 0.0785 0.1825
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0258 0.054
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0273 0.0629
Echinococcus multilocularis peregrin 0.0033 0.0258 0.0258
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1633 0.3765
Trichomonas vaginalis esterase, putative 0.0074 0.0785 0.4728
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0785 0.4728
Plasmodium falciparum dihydroorotate dehydrogenase 0.0351 0.4291 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.5863 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0785 0.1297
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0351 0.4291 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.2294 0.5427
Toxoplasma gondii hypothetical protein 0.0048 0.0452 0.0996
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0374 0.0812
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0144 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Leishmania major trypanothione reductase 0.0042 0.0378 0.0821
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.1064 0.1776
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0034 0.0014
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0141 0.1629 1
Leishmania major hypothetical protein, conserved 0.0074 0.0785 0.1775
Leishmania major importin beta-1 subunit, putative 0.0026 0.0175 0.0346
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1545 0.3654
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2294 0.2294
Plasmodium falciparum phd finger protein, putative 0.0033 0.0258 0.0594
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0351 0.4291 1
Brugia malayi PHD-finger family protein 0.0033 0.0258 0.0598
Mycobacterium tuberculosis Conserved protein 0.0074 0.0785 0.1297
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0175 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Trichomonas vaginalis ran, putative 0.0024 0.0144 0.0728
Brugia malayi MH2 domain containing protein 0.0134 0.1545 0.3598
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1437 0.8802
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.1201 0.1187
Schistosoma mansoni hypothetical protein 0.0036 0.0293 0.0287
Plasmodium vivax importin-beta 2, putative 0.0032 0.0253 0.0582
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0785 0.0848
Mycobacterium ulcerans lipase LipD 0.0074 0.0785 0.1775
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0273 0.1531
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0374 0.0812
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1633 0.3765
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0144 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0034 0.0014
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.1146
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0446 0.1037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0949 0.2242
Loa Loa (eye worm) hypothetical protein 0.0074 0.0785 0.1854
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0338
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0258 0.0594
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0346 0.0346
Entamoeba histolytica Ran family GTPase 0.0024 0.0144 0.0162
Brugia malayi beta-lactamase family protein 0.0074 0.0785 0.1825
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.2294 0.5344
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0551 0.1228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0949 0.1025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0144 0.0329
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.1146
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.012 0.0216
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2804 0.2804
Loa Loa (eye worm) hypothetical protein 0.0188 0.2233 0.5283
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0293 0.0293
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0949 0.1025
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.012 0.0216
Loa Loa (eye worm) hypothetical protein 0.0087 0.0949 0.2242

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiaging effect in Saccharomyces cerevisiae K6001 expressing uth1 mutant assessed as extension of replicative life span after 2 days ChEMBL. 20093034
Activity (functional) Effect on SOD1 gene expression in Saccharomyces cerevisiae K6001 at 10 uM by RT-PCR ChEMBL. 20093034
Activity (functional) Antiaging effect in Saccharomyces cerevisiae K6001 expressing skn7 mutant assessed as extension of replicative life span after 2 days ChEMBL. 20093034
Activity (functional) Effect on SIRT1 expression in Saccharomyces cerevisiae K6001 by SIRT1/Sir2 deacetylase fluorometric assay ChEMBL. 20093034
Activity (functional) Effect on SOD2 gene expression in Saccharomyces cerevisiae K6001 at 10 uM by RT-PCR ChEMBL. 20093034
Activity (functional) Antiaging effect in Saccharomyces cerevisiae K6001 assessed as extension of replicative life span at 10 uM after 2 days ChEMBL. 20093034

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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