Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | vitamin D receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | vitamin D receptor | 422 aa | 396 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.3696 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0368 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.3696 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0144 | 0.3696 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0144 | 0.3696 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0144 | 0.3696 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0368 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0368 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0368 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0368 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0368 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0368 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0368 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0368 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0144 | 0.3696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 30 % | Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant VDR expressed in Escherichia coli BL21 (DE3) | ChEMBL. | 18539034 |
Activity (binding) | = 1450 % | Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assay relative to 1-alpha, 25-(OH)2D3 | ChEMBL. | 18539034 |
EC50 (binding) | = 0.058 nM | Increase in mouse VDR-mediated transcriptional activity in african green monkey COS7 cells after 24 hrs by luciferase assay | ChEMBL. | 18539034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.