Detailed information for compound 1649993

Basic information

Technical information
  • TDR Targets ID: 1649993
  • Name: 9-phenyl-1,5,6,7,8,9-hexahydrotetrazolo[5,1-b ]quinazoline
  • MW: 253.302 | Formula: C14H15N5
  • H donors: 1 H acceptors: 3 LogP: 2.44 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C1C2=C(CCCC2)Nc2n1nnn2
  • InChi: 1S/C14H15N5/c1-2-6-10(7-3-1)13-11-8-4-5-9-12(11)15-14-16-17-18-19(13)14/h1-3,6-7,13H,4-5,8-9H2,(H,15,16,18)
  • InChiKey: QAADUBHZGNZSOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-phenyl-1,5,6,7,8,9-hexahydro-[1,2,3,4]tetrazolo[5,1-b]quinazoline
  • NCI60_041469
  • NSC721068
  • Oprea1_657316
  • STK008961

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0227 0.0421
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0154 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.1 0.1855
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.2319 0.2319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.1 0.1
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.1 0.1855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0323 0.0598
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.3599 0.6677
Loa Loa (eye worm) hypothetical protein 0.0613 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.031
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0227 0.0227
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.1 0.1855
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0227 0.0421
Brugia malayi hypothetical protein 0.004 0.0227 0.0227
Brugia malayi hypothetical protein 0.0238 0.3599 0.3599
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1 0.1
Brugia malayi Cytochrome P450 family protein 0.003 0.0047 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0541 0.1004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.1 0.1855
Brugia malayi nuclear receptor NHR-88 0.004 0.0227 0.0227
Brugia malayi nuclear receptor NHR-88 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0574 0.1065
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.2319 0.4303
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0227 0.0421
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0227 0.0227
Echinococcus multilocularis geminin 0.0171 0.2448 0.4541
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0541 0.1004
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0541 0.1004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.1 0.1855
Onchocerca volvulus 0.0094 0.1146 1
Entamoeba histolytica hypothetical protein 0.0113 0.1462 1
Brugia malayi Nuclear hormone receptor E75 0.004 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0574 0.0518
Onchocerca volvulus 0.0089 0.106 0.9251
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1699 0.3153
Echinococcus granulosus jun protein 0.0089 0.1058 0.1963
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0154 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.1 0.1855
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.1 0.1855
Echinococcus granulosus geminin 0.0171 0.2448 0.4541
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0227 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.1 0.1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0227 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.1 0.1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.2319 0.2319
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2286 0.4242
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0154 0.5
Echinococcus multilocularis jun protein 0.0089 0.1058 0.1963
Schistosoma mansoni tyrosinase precursor 0.0089 0.106 0.1967
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.1 0.1
Trypanosoma brucei squalene monooxygenase, putative 0.0511 0.826 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0574 0.1968
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0574 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0574 0.5
Entamoeba histolytica hypothetical protein 0.0113 0.1462 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0541 0.1004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0574 0.1065
Schistosoma mansoni jun-related protein 0.0072 0.0773 0.1434
Brugia malayi jmjC domain containing protein 0.0059 0.0541 0.0541
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0047 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0365 0.0365
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0343 0.539 0.6459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0323 0.0598
Loa Loa (eye worm) hypothetical protein 0.0161 0.2286 0.2286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0323 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.1 0.1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0227 0.0421
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0343 0.539 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.1058 0.1963
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3515 0.3515
Loa Loa (eye worm) DR-78 0.004 0.0227 0.0227
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.1 0.1855
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0343 0.539 1
Schistosoma mansoni hypothetical protein 0.0171 0.2448 0.4541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0323 0.0598
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.106 0.106
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.1 0.1855
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.1 0.1855
Brugia malayi ecdysteroid receptor 0.0086 0.1 0.1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1 0.1855
Onchocerca volvulus 0.0089 0.106 0.9251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1 0.1855
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0154 0.0286
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0227 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1 0.1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0154 0.0286
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0574 0.5
Entamoeba histolytica hypothetical protein 0.0113 0.1462 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0574 0.1065
Schistosoma mansoni tyrosinase precursor 0.0089 0.106 0.1967
Schistosoma mansoni nuclear hormone receptor 0.0086 0.1 0.1855
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.106 0.106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.1 0.1855
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.1 0.1855
Brugia malayi nuclear hormone receptor 0.004 0.0227 0.0227
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0323 0.0323
Brugia malayi ecdysone receptor 0.004 0.0227 0.0227
Brugia malayi photoreceptor-specific nuclear receptor 0.0086 0.1 0.1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2286 0.2286
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0227 0.1979
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2319 0.4303
Loa Loa (eye worm) hypothetical protein 0.0087 0.1016 0.1016
Loa Loa (eye worm) hypothetical protein 0.0089 0.106 0.106
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0227 0.0421
Leishmania major squalene monooxygenase-like protein 0.0511 0.826 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.031
Brugia malayi bZIP transcription factor family protein 0.0089 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1462 0.2712
Schistosoma mansoni carbonic anhydrase 0.0161 0.2286 0.4242
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0171 0.2448 0.4541
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.1 0.1855
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0161 0.2286 0.2286
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0154 0.5
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2286 0.2286
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0227 0.0421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.031 0.0574
Toxoplasma gondii hypothetical protein 0.0161 0.2286 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.1 0.1855
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0072 0.0773 0.1434
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Schistosoma mansoni thyroid hormone receptor 0.0212 0.3162 0.5867
Brugia malayi hypothetical protein 0.0045 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0127 0.1699 0.3153
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0343 0.539 0.539
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.1058 0.1963
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0541 0.1004
Brugia malayi nuclear receptor NHR-67 0.004 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0089 0.106 0.106
Brugia malayi steroid hormone receptor 0.0086 0.1 0.1
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.031 0.031
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0154 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.1 0.8722
Onchocerca volvulus 0.0086 0.1 0.8722
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2286 0.4242
Schistosoma mansoni hypothetical protein 0.0161 0.2286 0.4242
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0343 0.539 0.539
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.3599 0.6677
Brugia malayi hypothetical protein 0.007 0.0731 0.0731
Brugia malayi nuclear receptor RXR 0.0045 0.031 0.031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0154 0.0154
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.106 0.106
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0227 0.0421
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.1 0.1855
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.1 0.8722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.1 0.1
Leishmania major carbonic anhydrase-like protein 0.0343 0.539 0.6459
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0541 0.0541
Schistosoma mansoni nuclear hormone receptor 0.004 0.0227 0.0421
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2286 0.4242
Brugia malayi jmjC domain containing protein 0.0059 0.0541 0.0541
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.1 0.1
Onchocerca volvulus 0.004 0.0227 0.1979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.0161 0.2286 0.2286
Schistosoma mansoni nuclear hormone receptor 0.004 0.0227 0.0421
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.1 0.1855
Brugia malayi Nuclear hormone receptor E75 0.004 0.0227 0.0227
Echinococcus granulosus carbonic anhydrase 0.0161 0.2286 0.4242
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Loa Loa (eye worm) tyrosinase 1 0.0089 0.106 0.106
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1462 0.2712
Schistosoma mansoni nuclear receptor 0.004 0.0227 0.0421
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Brugia malayi hypothetical protein 0.004 0.0227 0.0227
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.1 0.8722
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.1 0.1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1699 0.3153
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.031
Schistosoma mansoni nuclear receptor 0.004 0.0227 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.1 0.1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.1 0.1855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0323 0.0598
Schistosoma mansoni alpha-glucosidase 0.014 0.1932 0.3584
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1 0.1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.1 0.1
Brugia malayi hypothetical protein 0.0045 0.031 0.031
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0343 0.539 0.539
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.1 0.1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0323 0.0598
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2286 0.4242
Loa Loa (eye worm) hypothetical protein 0.0238 0.3599 0.3599
Trypanosoma cruzi squalene monooxygenase, putative 0.0511 0.826 1
Onchocerca volvulus 0.004 0.0227 0.1979
Loa Loa (eye worm) hypothetical protein 0.0161 0.2286 0.2286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0086 0.1 0.1855
Schistosoma mansoni hypothetical protein 0.0113 0.1462 0.2712
Brugia malayi tailless protein 0.004 0.0227 0.0227
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.1 0.1
Echinococcus granulosus carbonic anhydrase 0.0161 0.2286 0.4242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0574 0.5
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0154 0.5
Loa Loa (eye worm) carbonic anhydrase 3 0.0343 0.539 0.539
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0154 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0086 0.1 0.1855
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0161 0.2286 0.2286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.031 0.0574
Brugia malayi conserved hypotetical protein 0.004 0.0227 0.0227
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.106 0.106
Echinococcus multilocularis thyroid hormone receptor alpha 0.0212 0.3162 0.5867
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0323 0.0323
Schistosoma mansoni zinc finger protein 0.004 0.0227 0.0421
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Onchocerca volvulus 0.0049 0.0365 0.3187
Schistosoma mansoni hypothetical protein 0.0049 0.0365 0.0678
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2319 0.4303
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0227 0.0421
Onchocerca volvulus 0.007 0.0731 0.638
Brugia malayi nuclear receptor RXR 0.004 0.0227 0.0227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1 0.1855
Onchocerca volvulus 0.0089 0.106 0.9251
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.1 0.1
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.031 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1 0.1855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Brugia malayi nuclear hormone receptor 0.0086 0.1 0.1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0574 0.1065
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0161 0.2286 0.2286
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0161 0.2286 0.2286
Schistosoma mansoni alpha glucosidase 0.0036 0.0154 0.0286
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.106 0.106
Echinococcus granulosus FTZ F1 alpha 0.0086 0.1 0.1855
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Echinococcus granulosus carbonic anhydrase 0.0161 0.2286 0.4242
Echinococcus multilocularis carbonic anhydrase II 0.0343 0.539 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0227 0.1979
Echinococcus multilocularis carbonic anhydrase 0.0161 0.2286 0.4242
Entamoeba histolytica hypothetical protein 0.0113 0.1462 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.106 0.106
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.1 0.1855
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0227 0.0227
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0227 0.0227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0541 0.1004
Schistosoma mansoni survival motor neuron protein 0.0049 0.0365 0.0678
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0154 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.1 0.1855
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.1 0.1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1 0.1
Echinococcus granulosus carbonic anhydrase II 0.0343 0.539 1
Onchocerca volvulus 0.0089 0.106 0.9251
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.031 0.0574
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0227 0.0421
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0227 0.0421
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.031 0.031
Schistosoma mansoni thyroid hormone receptor 0.0212 0.3162 0.5867
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0227 0.0421
Brugia malayi hypothetical protein 0.0113 0.1462 0.1462
Plasmodium falciparum carbonic anhydrase 0.0161 0.2286 0.5
Schistosoma mansoni coup transcription factor 0.0086 0.1 0.1855
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.1 0.1
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3515 0.3515
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1 0.1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0343 0.539 0.6459
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0323 0.0598
Schistosoma mansoni alpha-glucosidase 0.014 0.1932 0.3584
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0227 0.0421
Trypanosoma cruzi squalene monooxygenase, putative 0.0511 0.826 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.031 0.0574
Brugia malayi ShTK domain containing protein 0.0089 0.106 0.106
Trypanosoma brucei carbonic anhydrase-like protein 0.0343 0.539 0.6459
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0227 0.0421
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.106 0.106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.031
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0541 0.1004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1462 0.2712
Schistosoma mansoni carbonic anhydrase-related 0.0161 0.2286 0.4242

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.48 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.311 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.084 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.007 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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