Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.2822 | 0.2822 |
Echinococcus granulosus | lamin | 0.0031 | 0.2822 | 0.2616 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.2822 | 0.2822 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.2822 | 0.2616 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0068 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.2822 | 0.2616 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0068 | 1 | 1 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0018 | 0.0279 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.2822 | 0.5 | |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0068 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0068 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0068 | 1 | 1 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0018 | 0.0279 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0279 | 0.0279 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.2822 | 0.2616 |
Plasmodium vivax | JmjC domain containing protein | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2711 | 0.2711 |
Schistosoma mansoni | lamin | 0.0031 | 0.2822 | 0.2616 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0018 | 0.0279 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.2822 | 0.2616 |
Echinococcus multilocularis | lamin | 0.0031 | 0.2822 | 0.2616 |
Echinococcus multilocularis | musashi | 0.0031 | 0.2822 | 0.2616 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2822 | 0.2822 |
Onchocerca volvulus | 0.0031 | 0.2822 | 0.5 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0068 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.2822 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0018 | 0.0279 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0279 | 0.0279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.372 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.367 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.343 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.343 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.332 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.174 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.166 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.123 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.012 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.