Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0162 | 0.104 | 0.104 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0082 | 0.0197 | 0.0197 |
Entamoeba histolytica | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0307 | 0.2561 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0082 | 0.0197 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Schistosoma mansoni | thyroid hormone receptor | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0307 | 0.2561 | 0.2561 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0082 | 0.0197 | 0.0768 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0307 | 0.2561 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0162 | 0.104 | 0.4061 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1014 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0307 | 0.2561 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0307 | 0.2561 | 0.2561 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0307 | 0.2561 | 0.2561 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0082 | 0.0197 | 0.0768 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | histone deacetylase | 0.0082 | 0.0197 | 0.0197 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0082 | 0.0197 | 0.0768 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0307 | 0.2561 | 0.2561 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0082 | 0.0197 | 0.0768 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | histone deacetylase | 0.0082 | 0.0197 | 0.0197 |
Schistosoma mansoni | P2X receptor subunit | 0.1014 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0082 | 0.0197 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0145 | 0.0858 | 0.3349 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0307 | 0.2561 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0307 | 0.2561 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0162 | 0.104 | 0.4061 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0145 | 0.0858 | 0.0858 |
Plasmodium falciparum | histone deacetylase 1 | 0.0082 | 0.0197 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1014 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0145 | 0.0858 | 0.0858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0307 | 0.2561 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0145 | 0.0858 | 0.0858 |
Schistosoma mansoni | nuclear receptor | 0.0145 | 0.0858 | 0.0858 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0307 | 0.2561 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Brugia malayi | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0145 | 0.0858 | 0.0858 |
Loa Loa (eye worm) | DR-78 | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | histone deacetylase 3 | 0.0082 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0307 | 0.2561 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0307 | 0.2561 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0307 | 0.2561 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | conserved hypotetical protein | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Schistosoma mansoni | coup transcription factor | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Onchocerca volvulus | 0.0307 | 0.2561 | 1 | |
Plasmodium vivax | histone deacetylase 1, putative | 0.0082 | 0.0197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0145 | 0.0858 | 0.0858 |
Brugia malayi | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | steroid hormone receptor | 0.0307 | 0.2561 | 1 |
Brugia malayi | tailless protein | 0.0145 | 0.0858 | 0.3349 |
Schistosoma mansoni | nuclear hormone receptor | 0.0145 | 0.0858 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0307 | 0.2561 | 0.2561 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0145 | 0.0858 | 0.0858 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0145 | 0.0858 | 0.0858 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.1014 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0145 | 0.0858 | 0.0858 |
Echinococcus multilocularis | histone deacetylase 6 | 0.007 | 0.007 | 0.007 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0307 | 0.2561 | 0.2561 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0082 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0145 | 0.0858 | 0.0858 |
Schistosoma mansoni | histone deacetylase hda2 | 0.007 | 0.007 | 0.007 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0145 | 0.0858 | 0.0858 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0145 | 0.0858 | 0.0858 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0307 | 0.2561 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0307 | 0.2561 | 0.2561 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.1014 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0307 | 0.2561 | 0.2561 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0307 | 0.2561 | 1 |
Leishmania major | histone deacetylase, putative | 0.0082 | 0.0197 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0162 | 0.104 | 0.104 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0307 | 0.2561 | 1 |
Giardia lamblia | Histone deacetylase | 0.0082 | 0.0197 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1014 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0307 | 0.2561 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0082 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Brugia malayi | nuclear receptor NHR-67 | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0307 | 0.2561 | 0.2561 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0145 | 0.0858 | 0.0858 |
Schistosoma mansoni | P2X receptor subunit | 0.1014 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0307 | 0.2561 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0307 | 0.2561 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0307 | 0.2561 | 0.2561 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0307 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0307 | 0.2561 | 1 |
Leishmania major | histone deacetylase, putative | 0.0082 | 0.0197 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | P2X receptor subunit | 0.1014 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0162 | 0.104 | 0.4061 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0307 | 0.2561 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0082 | 0.0197 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0082 | 0.0197 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0145 | 0.0858 | 0.3349 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0145 | 0.0858 | 0.0858 |
Echinococcus granulosus | histone deacetylase 6 | 0.007 | 0.007 | 0.007 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0145 | 0.0858 | 0.0858 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0307 | 0.2561 | 0.2561 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0307 | 0.2561 | 0.2561 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0307 | 0.2561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0145 | 0.0858 | 0.3349 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0307 | 0.2561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2561 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.1014 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0307 | 0.2561 | 0.2561 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0162 | 0.104 | 0.104 |
Brugia malayi | hypothetical protein | 0.0162 | 0.104 | 0.4061 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0307 | 0.2561 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0145 | 0.0858 | 0.0858 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0145 | 0.0858 | 0.0858 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0307 | 0.2561 | 0.2561 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0307 | 0.2561 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0307 | 0.2561 | 0.2561 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0082 | 0.0197 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0307 | 0.2561 | 0.2561 |
Trypanosoma brucei | histone deacetylase 1 | 0.0082 | 0.0197 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0162 | 0.104 | 0.4061 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | ecdysone receptor | 0.0145 | 0.0858 | 0.3349 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0145 | 0.0858 | 0.0858 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0307 | 0.2561 | 0.2561 |
Schistosoma mansoni | zinc finger protein | 0.0145 | 0.0858 | 0.0858 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0307 | 0.2561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0197 | 0.0768 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0162 | 0.104 | 0.104 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0082 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0858 | 0.3349 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.81 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.624 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.483 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.395 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.079 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.