Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.2083 | 0.4464 |
Echinococcus granulosus | tar DNA binding protein | 0.0052 | 0.4666 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.2083 | 0.4464 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.065 | 0.121 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.065 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0052 | 0.4666 | 0.4666 |
Brugia malayi | hypothetical protein | 0.0029 | 0.065 | 0.065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.2083 | 0.3877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.2083 | 0.3877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0052 | 0.4666 | 0.8686 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0037 | 0.2083 | 0.2083 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0029 | 0.065 | 0.121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0052 | 0.4666 | 0.8686 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.065 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0037 | 0.2083 | 0.2083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0052 | 0.4666 | 0.8686 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.2083 | 0.4464 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0052 | 0.4666 | 0.4666 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0029 | 0.065 | 0.1393 |
Loa Loa (eye worm) | RNA binding protein | 0.0052 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0052 | 0.4666 | 0.8686 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.065 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0052 | 0.4666 | 0.8686 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.2083 | 0.4464 |
Brugia malayi | RNA binding protein | 0.0052 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | TAR-binding protein | 0.0052 | 0.4666 | 0.4666 |
Brugia malayi | TAR-binding protein | 0.0052 | 0.4666 | 0.4666 |
Echinococcus multilocularis | tar DNA binding protein | 0.0052 | 0.4666 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0056 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0081 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.5371 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.2083 | 0.3877 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0029 | 0.065 | 0.1393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.167 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.