Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0074 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0074 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0074 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0074 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0074 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0074 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0037 | 0.0151 | 0.0151 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0074 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0074 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0074 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0074 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0074 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0046 | 0.2407 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0074 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0074 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0074 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0065 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0074 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0074 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0074 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0074 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0046 | 0.2407 | 0.2407 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0065 | 0.7743 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.683 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.569 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.524 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.51 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.476 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.422 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.417 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.399 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.076 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.