Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | slit 2 protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2219 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | peroxidasin | 0.2219 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0055 | 0.0073 | 0.0073 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0124 | 0.0388 | 0.0388 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2219 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0509 | 0.2157 | 0.2157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0124 | 0.039 | 0.1027 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0543 | 0.2312 | 0.2312 |
Brugia malayi | Animal haem peroxidase family protein | 0.2219 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.2219 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | 0.2219 | 1 | 1 | |
Echinococcus multilocularis | protein jagged 1 | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0055 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | notch-like transmembrane receptor | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Giardia lamblia | High cysteine protein | 0.0509 | 0.2157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2219 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | neural cadherin | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | geminin | 0.0118 | 0.0361 | 0.0361 |
Onchocerca volvulus | Peroxidasin homolog | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0361 | 0.0361 |
Brugia malayi | Blistered cuticle protein 3 | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | 0.0509 | 0.2157 | 0.1864 | |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Cadherin domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Animal haem peroxidase family protein | 0.2219 | 1 | 1 |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | protein jagged 1 | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | Notch2 | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | protein jagged 2 | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0509 | 0.2157 | 0.1864 |
Loa Loa (eye worm) | notch protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0084 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0124 | 0.0388 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | 0.0509 | 0.2157 | 0.1864 | |
Brugia malayi | Delta serrate ligand family protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Animal haem peroxidase family protein | 0.2219 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | Peroxidase homolog | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0543 | 0.2312 | 0.2312 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0509 | 0.2157 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Onchocerca volvulus | 0.2219 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Muscle positioning protein 4 | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.2219 | 1 | 1 |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | protein jagged 1 | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | 0.0509 | 0.2157 | 0.1864 | |
Echinococcus multilocularis | fibropellin Ia | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.2219 | 1 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0179 | 0.0644 | 0.0644 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.024 | 0.0922 | 0.0922 |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Cadherin domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | notch | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | EGF-like domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | Peroxidase homolog | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | septate junction protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Echinococcus granulosus | geminin | 0.0118 | 0.0361 | 0.0361 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0179 | 0.0644 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0543 | 0.2312 | 0.2312 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | 0.0509 | 0.2157 | 0.1864 | |
Echinococcus granulosus | neurogenic locus notch protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | Peroxidasin homolog | 0.2219 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0124 | 0.039 | 0.1027 |
Echinococcus multilocularis | notch | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | Dual oxidase homolog | 0.2219 | 1 | 1 |
Onchocerca volvulus | 0.0509 | 0.2157 | 0.1864 | |
Schistosoma mansoni | notch | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | protein jagged 2 | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | delta-like protein 1 | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | slit | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Peroxidasin | 0.2219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0388 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.0644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Onchocerca volvulus | Putative cubilin | 0.0509 | 0.2157 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Echinococcus multilocularis | neural cadherin | 0.0509 | 0.2157 | 0.2157 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0055 | 0.0073 | 0.0073 |
Onchocerca volvulus | Slit protein homolog | 0.0509 | 0.2157 | 0.1864 |
Schistosoma mansoni | peroxidasin | 0.2219 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0509 | 0.2157 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.2219 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0124 | 0.0388 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0361 | 0.0361 |
Onchocerca volvulus | 0.2219 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0509 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2157 | 0.2157 |
Brugia malayi | Animal haem peroxidase family protein | 0.2219 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.2219 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0509 | 0.2157 | 0.2157 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.193 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.161 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.093 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.