Detailed information for compound 1650924

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.732 | Formula: C14H13ClN4O
  • H donors: 3 H acceptors: 3 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNc1nc(Cl)cc(c1)c1c[nH]c2c1cccn2
  • InChi: 1S/C14H13ClN4O/c15-12-6-9(7-13(19-12)16-4-5-20)11-8-18-14-10(11)2-1-3-17-14/h1-3,6-8,20H,4-5H2,(H,16,19)(H,17,18)
  • InChiKey: BERZRFJWHSXBCR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peroxidasin 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0063 0.3554
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) Notch2 0.0179 0.1304 0.1304
Brugia malayi Peroxidasin 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Brugia malayi Calcium binding EGF domain containing protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) animal heme peroxidase 0.1 1 1
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Echinococcus multilocularis neurogenic locus notch protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) blistered cuticle protein 3 0.1 1 1
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0208 0.1612 0.1612
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0196 0.1486 0.1486
Brugia malayi notch-like transmembrane receptor 0.0179 0.1304 0.1304
Echinococcus granulosus peroxidasin 0.1 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.1 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0177 1
Echinococcus multilocularis neural cadherin 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Onchocerca volvulus 0.0072 0.0177 0.0115
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Brugia malayi GCC2 and GCC3 family protein 0.0179 0.1304 0.1304
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) animal heme peroxidase 0.1 1 1
Echinococcus granulosus neural cadherin 0.0179 0.1304 0.1304
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0063 1
Echinococcus granulosus neurogenic locus notch protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0208 0.1612 0.1612
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0076 0.0218 0.0218
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Brugia malayi Protein kinase domain containing protein 0.0196 0.1486 0.1486
Loa Loa (eye worm) notch protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Echinococcus granulosus rho-associated protein kinase 1 0.018 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0196 0.1486 0.1433
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0177 1
Onchocerca volvulus 0.018 0.1312 0.1257
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0196 0.1486 0.1486
Echinococcus multilocularis neurogenic locus notch protein 0.0179 0.1304 0.1304
Echinococcus multilocularis slit 2 protein 0.0179 0.1304 0.1304
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Onchocerca volvulus Peroxidasin homolog 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis protein jagged 1 0.0179 0.1304 0.1304
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Schistosoma mansoni laminin gamma-3 chain 0.0179 0.1304 0.1304
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.055 0.5234 0.5234
Onchocerca volvulus 0.0072 0.0177 0.0115
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0179 0.1304 0.1249
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Schistosoma mansoni protein kinase 0.0076 0.0218 0.0218
Brugia malayi Cadherin domain containing protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis notch 0.0179 0.1304 0.1304
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Echinococcus granulosus fibropellin Ia 0.0179 0.1304 0.1304
Onchocerca volvulus 0.0179 0.1304 0.1249
Loa Loa (eye worm) CDC7 protein kinase 0.0072 0.0177 0.0177
Schistosoma mansoni cell polarity protein 0.0179 0.1304 0.1304
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0063 0.0063
Echinococcus granulosus protein jagged 2 0.0179 0.1304 0.1304
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0063 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0196 0.1486 0.1486
Brugia malayi Animal haem peroxidase family protein 0.1 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0179 0.1304 0.1304
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Brugia malayi Cadherin domain containing protein 0.0179 0.1304 0.1304
Schistosoma mansoni peroxidasin 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis protein jagged 1 0.0179 0.1304 0.1304
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0208 0.1612 0.1612
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Echinococcus multilocularis peroxidasin 0.1 1 1
Onchocerca volvulus 0.0179 0.1304 0.1249
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.1612 0.1612
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0208 0.1612 0.1612
Echinococcus multilocularis neurogenic locus notch protein 4 0.0179 0.1304 0.1304
Echinococcus multilocularis neurogenic locus protein delta 0.0179 0.1304 0.1304
Onchocerca volvulus 0.0179 0.1304 0.1249
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Onchocerca volvulus Slit protein homolog 0.0179 0.1304 0.1249
Giardia lamblia Kinase, CDC7 0.0072 0.0177 0.1354
Onchocerca volvulus 0.0175 0.1269 0.1214
Echinococcus multilocularis neurogenic locus protein delta 0.0179 0.1304 0.1304
Entamoeba histolytica protein kinase, putative 0.0062 0.0063 0.0389
Echinococcus multilocularis rho associated protein kinase 0.018 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0179 0.1304 0.1304
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0063 0.0481
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Echinococcus multilocularis 0.0076 0.0218 0.0218
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0063 0.0481
Brugia malayi Protein kinase domain containing protein 0.055 0.5234 0.5234
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0063 0.0481
Schistosoma mansoni septate junction protein 0.0179 0.1304 0.1304
Schistosoma mansoni slit 0.0179 0.1304 0.1304
Echinococcus granulosus notch 0.0179 0.1304 0.1304
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Onchocerca volvulus 0.1 1 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Onchocerca volvulus Neurogenic locus notch homolog 0.0179 0.1304 0.1249
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1312 0.1312
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Echinococcus multilocularis fibropellin Ia 0.0179 0.1304 0.1304
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Brugia malayi Animal haem peroxidase family protein 0.1 1 1
Toxoplasma gondii EGF family domain-containing protein 0.0179 0.1304 1
Entamoeba histolytica protein kinase domain containing protein 0.0208 0.1612 1
Loa Loa (eye worm) animal heme peroxidase 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0496 0.0496
Onchocerca volvulus 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Brugia malayi Animal haem peroxidase family protein 0.1 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0063 0.0063
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0063 0.0389
Echinococcus granulosus protein kinase 0.0076 0.0218 0.0218
Echinococcus granulosus protein jagged 1 0.0179 0.1304 0.1304
Brugia malayi Protein kinase domain containing protein 0.0072 0.0177 0.0177
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0196 0.1486 0.1486
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0196 0.1486 0.1486
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Onchocerca volvulus Putative cubilin 0.0179 0.1304 0.1249
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0179 0.1304 0.1304
Onchocerca volvulus Dual oxidase homolog 0.1 1 1
Brugia malayi Animal haem peroxidase family protein 0.1 1 1
Onchocerca volvulus 0.0179 0.1304 0.1249
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0063 0.0063
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0063 0.0063
Onchocerca volvulus 0.1 1 1
Schistosoma mansoni protein kinase 0.0107 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Brugia malayi Animal haem peroxidase family protein 0.1 1 1
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Schistosoma mansoni hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) animal heme peroxidase 0.1 1 1
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Echinococcus granulosus protein jagged 2 0.0179 0.1304 0.1304
Brugia malayi Muscle positioning protein 4 0.0179 0.1304 0.1304
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0179 0.1304 0.1304
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0063 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1486 0.1486
Brugia malayi Calcium binding EGF domain containing protein 0.0179 0.1304 0.1304
Brugia malayi intracellular kinase 0.0062 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.1 1 1
Onchocerca volvulus Peroxidase homolog 0.1 1 1
Trypanosoma brucei protein kinase, putative 0.0062 0.0063 1
Onchocerca volvulus Peroxidasin homolog 0.1 1 1
Brugia malayi probable protein kinase 0.0107 0.0539 0.0539
Echinococcus granulosus neurogenic locus notch protein 0.0179 0.1304 0.1304
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Schistosoma mansoni notch 0.0179 0.1304 0.1304
Onchocerca volvulus 0.0179 0.1304 0.1249
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Brugia malayi Delta serrate ligand family protein 0.0179 0.1304 0.1304
Echinococcus granulosus neurogenic locus protein delta 0.0179 0.1304 0.1304
Giardia lamblia High cysteine protein 0.0179 0.1304 1
Echinococcus granulosus delta-like protein 1 0.0179 0.1304 0.1304
Echinococcus granulosus protein jagged 1 0.0179 0.1304 0.1304
Echinococcus granulosus CDC7 cell division cycle 7 0.0072 0.0177 0.0177
Echinococcus granulosus protein kinase shaggy 0.0062 0.0063 0.0063
Brugia malayi EGF-like domain containing protein 0.0179 0.1304 0.1304
Echinococcus multilocularis CDC7 cell division cycle 7 0.0072 0.0177 0.0177
Onchocerca volvulus Peroxidase homolog 0.1 1 1
Echinococcus granulosus slit 2 protein 0.0179 0.1304 0.1304
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0063 0.0389
Brugia malayi Blistered cuticle protein 3 0.1 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0063 0.3554
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304
Echinococcus multilocularis protein jagged 2 0.0179 0.1304 0.1304
Loa Loa (eye worm) hypothetical protein 0.0179 0.1304 0.1304

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) = 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 7.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 7.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) = 8.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 8.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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