Detailed information for compound 1651014

Basic information

Technical information
  • TDR Targets ID: 1651014
  • Name: 1,5-dimethylpyrazolo[4,5-e]pyrimidin-4-imine
  • MW: 163.18 | Formula: C7H9N5
  • H donors: 0 H acceptors: 1 LogP: -0.38 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=c1n(C)cnc2c1cnn2C
  • InChi: 1S/C7H9N5/c1-11-4-9-7-5(6(11)8)3-10-12(7)2/h3-4,8H,1-2H3
  • InChiKey: CRCJKNGIKFKKII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,5-dimethyl-4-pyrazolo[4,5-e]pyrimidinimine
  • (1,5-dimethylpyrazolo[4,5-e]pyrimidin-4-ylidene)amine
  • 6267-41-0
  • NSC34518

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0022 0.0013
Onchocerca volvulus 0.0016 0.0022 0.0001
Loa Loa (eye worm) RNA binding protein 0.007 0.0567 0.0576
Schistosoma mansoni microtubule-associated protein tau 0.0767 0.7554 0.7549
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0016 0.0022 0.0017
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0056 0.139
Echinococcus granulosus tyrosine kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis tar DNA binding protein 0.007 0.0567 0.0571
Loa Loa (eye worm) TK/FAK protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0161 0.0164
Brugia malayi Tyrosine-protein kinase PR2 0.0016 0.0022 0.0001
Onchocerca volvulus 0.0055 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0124
Schistosoma mansoni tar DNA-binding protein 0.007 0.0567 0.0546
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase csk 0.0016 0.0022 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0122 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0122 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.0022 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Echinococcus multilocularis cysteine protease 0.0016 0.0022 0.0017
Echinococcus granulosus activin receptor type 0.0016 0.0022 0.0017
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0016 0.0022 0.0017
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0014
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0022 0.0001
Brugia malayi SRC-1 0.0016 0.0022 0.0001
Echinococcus multilocularis natriuretic peptide receptor 1 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase ABL1 0.0016 0.0022 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0567 0.0576
Echinococcus granulosus lamin dm0 0.003 0.0161 0.0158
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0423 0.8824
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0036 0.0031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0416 0.0423
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0022 0.0017
Onchocerca volvulus 0.003 0.0161 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Onchocerca volvulus 0.0016 0.0022 0.0001
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.0022 0.0001
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0016 0.0022 0.0017
Echinococcus multilocularis microtubule associated protein 2 0.0767 0.7554 0.7677
Echinococcus granulosus integrin linked protein kinase 0.0016 0.0022 0.0017
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0056 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase csk 0.0016 0.0022 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0122 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0036 0.0031
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0022 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Echinococcus multilocularis transfer RNA-Thr 0.0016 0.0022 0.0017
Schistosoma mansoni hypothetical protein 0.0205 0.1914 0.1896
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0767 0.7554 0.7677
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0016 0.0022 0.0017
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0022 0.0017
Echinococcus granulosus intermediate filament protein 0.003 0.0161 0.0158
Echinococcus granulosus epidermal growth factor receptor 0.0016 0.0022 0.0017
Onchocerca volvulus 0.003 0.0161 0.3566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0158
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0994 0.9838 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0022 0.0017
Brugia malayi hypothetical protein 0.0016 0.0022 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0122 0.2192
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0122 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0056 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0023
Loa Loa (eye worm) TK/Met protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Giardia lamblia Kinase, NEK 0.0016 0.0022 0.5
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0994 0.9838 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis kinase suppressor of Ras 1 0.0016 0.0022 0.0017
Onchocerca volvulus 0.0016 0.0022 0.0001
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine kinase 0.0016 0.0022 0.0017
Echinococcus multilocularis protein KINase family member (kin 25) 0.0016 0.0022 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0022 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.024 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Echinococcus granulosus geminin 0.0205 0.1914 0.1941
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0122 1
Echinococcus granulosus tar DNA binding protein 0.007 0.0567 0.0571
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0016 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0122 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus epidermal growth factor receptor 0.0016 0.0022 0.0017
Brugia malayi Raf kinase 0.0016 0.0022 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0022 0.0000045052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus insulin receptor 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase Blk 0.0016 0.0022 0.0017
Brugia malayi protein-tyrosine kinase 0.0016 0.0022 0.0001
Echinococcus multilocularis FL cytokine receptor 0.0016 0.0022 0.0017
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis epidermal growth factor receptor 0.0016 0.0022 0.0017
Echinococcus multilocularis epidermal growth factor receptor 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0124
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0016 0.0022 0.0017
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.0022 0.0017
Onchocerca volvulus 0.0016 0.0022 0.0001
Echinococcus granulosus GPCR family 2 0.0018 0.0036 0.0031
Schistosoma mansoni hypothetical protein 0.0205 0.1914 0.1896
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus raf serine:threonine protein kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0057
Echinococcus granulosus fibroblast growth factor receptor 4 0.0016 0.0022 0.0017
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0016 0.0022 0.0017
Echinococcus multilocularis protein kinase 0.0016 0.0022 0.0017
Toxoplasma gondii cathepsin CPL 0.0016 0.0022 1
Echinococcus multilocularis integrin linked protein kinase 0.0016 0.0022 0.0017
Schistosoma mansoni tar DNA-binding protein 0.007 0.0567 0.0546
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0057
Schistosoma mansoni tar DNA-binding protein 0.007 0.0567 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0122 0.2192
Loa Loa (eye worm) TK/EGFR protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis lamin 0.003 0.0161 0.0158
Echinococcus granulosus natriuretic peptide receptor 1 0.0016 0.0022 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0022 0.0001
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Leishmania major cathepsin L-like protease 0.0061 0.0477 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0016 0.0022 0.0001
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Schistosoma mansoni tar DNA-binding protein 0.007 0.0567 0.0546
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0016 0.0022 0.0017
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine protein kinase pr2 0.0016 0.0022 0.0017
Giardia lamblia Kinase, NEK 0.0016 0.0022 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0016 0.0022 0.0017
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0022 0.0017
Schistosoma mansoni lamin 0.003 0.0161 0.0139
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0016 0.0022 0.0017
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus tyrosine protein kinase 0.0016 0.0022 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0022 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Brugia malayi C-terminal src kinase protein 1 0.0016 0.0022 0.0001
Echinococcus multilocularis protein kinase 0.0016 0.0022 0.0017
Echinococcus multilocularis activated cdc42 kinase 1 0.0016 0.0022 0.0017
Schistosoma mansoni tar DNA-binding protein 0.007 0.0567 0.0546
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0122 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0016 0.0022 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0022 0.0005
Echinococcus multilocularis cysteine protease 0.0016 0.0022 0.0017
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0022 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0161 0.0142
Echinococcus multilocularis protein tyrosine kinase 0.0016 0.0022 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Onchocerca volvulus 0.0016 0.0022 0.0001
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0022 0.0017
Loa Loa (eye worm) intermediate filament protein 0.003 0.0161 0.0164
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis geminin 0.0205 0.1914 0.1941
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0345 0.7098
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0994 0.9838 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Brugia malayi hypothetical protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) fibroinase 0.0016 0.0022 0.0023
Echinococcus granulosus tumor protein p63 0.0375 0.3628 0.3684
Echinococcus multilocularis musashi 0.003 0.0161 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0022 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0122 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Echinococcus multilocularis lamin dm0 0.003 0.0161 0.0158
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0477 1
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi TAR-binding protein 0.007 0.0567 0.0555
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0036 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0036 0.0015
Echinococcus granulosus kinase suppressor of Ras 1 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase Blk 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis ephrin type A receptor 4 A 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase 0.0016 0.0022 0.0017
Echinococcus multilocularis tumor protein p63 0.0375 0.3628 0.3684
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi integrin-linked kinase 0.0016 0.0022 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) SRC-1 0.0016 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Brugia malayi hypothetical protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0036 0.0015
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0016 0.0022 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0022 0.0000045052
Echinococcus multilocularis heat shock protein 70 0.0016 0.0022 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0022 0.0017
Echinococcus granulosus protein tyrosine kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0022 0.0017
Echinococcus granulosus protein kinase 0.0016 0.0022 0.0017
Brugia malayi ephrin receptor 1 precursor 0.0016 0.0022 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0122 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi Protein kinase domain containing protein 0.0994 0.9838 1
Schistosoma mansoni lamin 0.003 0.0161 0.0139
Echinococcus multilocularis tyrosine protein kinase HCK 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0124
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0016 0.0022 0.0001
Brugia malayi SH2 domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0055 0.0416 0.0423
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) protein kinase domain-containing protein 0.0016 0.0022 0.0022
Schistosoma mansoni intermediate filament proteins 0.003 0.0161 0.0139
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.0022 0.0017
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.0994 0.9838 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0022 0.0023
Giardia lamblia Kinase 0.0016 0.0022 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0412 0.0419
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine protein kinase csk 0.0016 0.0022 0.0017
Giardia lamblia Protein 21.1 0.0016 0.0022 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0994 0.9838 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0016 0.0022 0.0022
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0022 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0477 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0161 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0016 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0057
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0022 0.0001
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0016 0.0022 0.0022
Plasmodium vivax vivapain-2 0.0016 0.0022 0.0013
Echinococcus granulosus tyrosine protein kinase pr2 0.0016 0.0022 0.0017
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0016 0.0022 0.0017
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.0022 0.0017
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0016 0.0022 0.0017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0022 0.0023
Echinococcus granulosus retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Brugia malayi SH2 domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) serine/threonine protein kinase 0.0016 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase shark 0.0016 0.0022 0.0017
Leishmania major cathepsin L-like protease 0.0061 0.0477 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0057
Echinococcus multilocularis GPCR, family 2 0.0018 0.0036 0.0031
Echinococcus granulosus tyrosine protein kinase csk 0.0016 0.0022 0.0017
Echinococcus granulosus activated cdc42 kinase 1 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase Srms 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0022 0.0017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0122 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0416 0.0402
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0038 0.024 0.0219
Echinococcus granulosus cathepsin l1 0.0016 0.0022 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK/CSK protein kinase 0.0016 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0026 0.0122 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) TK/ACK protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0022 0.0017
Plasmodium vivax vivapain-2 0.0016 0.0022 0.0013
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0122 0.0102
Echinococcus multilocularis insulin receptor 0.0016 0.0022 0.0017
Echinococcus granulosus retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus tyrosine protein kinase Srms 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0022 0.0017
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0021 0.0022
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0016 0.0022 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0122 1
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0122 1
Echinococcus granulosus tyrosine kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/INSR protein kinase 0.0016 0.0022 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0122 0.2192
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0022 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0122 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0412 0.0391
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0416 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Onchocerca volvulus 0.0016 0.0022 0.0001
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0022 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0022 0.0001
Brugia malayi Cathepsin L-like precursor 0.0016 0.0022 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0567 0.0555
Echinococcus multilocularis tyrosine kinase 0.0016 0.0022 0.0017
Brugia malayi Furin-like cysteine rich region family protein 0.0016 0.0022 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0477 1
Leishmania major cathepsin L-like protease 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.0022 0.0017
Onchocerca volvulus 0.0026 0.0122 0.2557
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0477 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0016 0.0022 0.0001
Loa Loa (eye worm) TK protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0477 1
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus tyrosine kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0022 0.0005
Echinococcus granulosus tyrosine protein kinase HCK 0.0016 0.0022 0.0017
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase csk 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Echinococcus multilocularis activin receptor type 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase csk 0.0016 0.0022 0.0017
Brugia malayi intermediate filament protein 0.003 0.0161 0.0142
Echinococcus multilocularis raf serine:threonine protein kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.024 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0022 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0022 0.0017
Echinococcus granulosus tyrosine protein kinase shark 0.0016 0.0022 0.0017
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0016 0.0022 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0022 1
Brugia malayi RNA binding protein 0.007 0.0567 0.0555
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Echinococcus granulosus lamin 0.003 0.0161 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0036 0.0031
Echinococcus granulosus ephrin type A receptor 4 A 0.0016 0.0022 0.0017
Loa Loa (eye worm) TAR-binding protein 0.007 0.0567 0.0576
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Brugia malayi bone morphogenetic protein type 1 receptor 0.0016 0.0022 0.0001
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0022
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0056 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0016 0.0022 0.0017
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0022 0.0022
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0016 0.0022 0.0017
Echinococcus multilocularis tyrosine protein kinase csk 0.0016 0.0022 0.0017
Echinococcus granulosus activated cdc42 kinase 1 0.0016 0.0022 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0122 0.0102
Leishmania major cathepsin L-like protease 0.0061 0.0477 1
Onchocerca volvulus 0.0016 0.0022 0.0001
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0016 0.0022 0.0017
Brugia malayi Protein kinase domain containing protein 0.0016 0.0022 0.0001
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0016 0.0022 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0022 0.0022
Loa Loa (eye worm) TK/RYK protein kinase 0.0016 0.0022 0.0022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1458 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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