Detailed information for compound 1651111

Basic information

Technical information
  • TDR Targets ID: 1651111
  • Name: 1-(2,4-dichlorophenyl)-N-[2-[2-[[1-(2,4-dichl orophenyl)4H-indeno[2,3-d]pyrazole-3-carbonyl ]amino]ethyl-methylamino]ethyl]-4H-indeno[2,3 -d]pyrazole-3-carboxamide
  • MW: 771.521 | Formula: C39H31Cl4N7O2
  • H donors: 2 H acceptors: 4 LogP: 8.65 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(CCNC(=O)c1nn(c2c1Cc1c2cccc1)c1ccc(cc1Cl)Cl)CCNC(=O)c1nn(c2c1Cc1c2cccc1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C39H31Cl4N7O2/c1-48(16-14-44-38(51)34-28-18-22-6-2-4-8-26(22)36(28)49(46-34)32-12-10-24(40)20-30(32)42)17-15-45-39(52)35-29-19-23-7-3-5-9-27(23)37(29)50(47-35)33-13-11-25(41)21-31(33)43/h2-13,20-21H,14-19H2,1H3,(H,44,51)(H,45,52)
  • InChiKey: PVIPVMAFOPCNHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2,4-dichlorophenyl)-N-[2-[2-[[1-(2,4-dichlorophenyl)4H-indeno[2,3-d]pyrazole-3-carbonyl]amino]ethyl-methyl-amino]ethyl]-4H-indeno[2,3-d]pyrazole-3-carboxamide
  • 1-(2,4-dichlorophenyl)-N-[2-[2-[[[1-(2,4-dichlorophenyl)-4H-indeno[2,3-d]pyrazol-3-yl]-oxomethyl]amino]ethyl-methylamino]ethyl]-4H-indeno[2,3-d]pyrazole-3-carboxamide
  • 1-(2,4-dichlorophenyl)-N-[2-[2-[[1-(2,4-dichlorophenyl)-4H-indeno[2,3-d]pyrazol-3-yl]carbonylamino]ethyl-methyl-amino]ethyl]-4H-indeno[2,3-d]pyrazole-3-carboxamide
  • NSC710412
  • NCI60_038861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0305 0.2903
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0795 0.2675
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Brugia malayi hypothetical protein 0.0026 0.0295 0.0993
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.002 0.0162 0.0547
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0229 0.164
Echinococcus multilocularis para nitrobenzyl esterase 0.0026 0.0295 0.0993
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0295 0.0295
Schistosoma mansoni rab6-interacting 0.0022 0.0219 0.0219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0795 0.2675
Loa Loa (eye worm) hypothetical protein 0.0022 0.0219 0.0738
Brugia malayi aspartic protease BmAsp-2, identical 0.002 0.0162 0.0547
Echinococcus multilocularis nervana 2 0.002 0.0181 0.061
Plasmodium vivax plasmepsin IV, putative 0.002 0.0162 0.1688
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Echinococcus granulosus RUN 0.0022 0.0219 0.0738
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.1007 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0305 0.1027
Brugia malayi Pepsin A precursor 0.002 0.0162 0.0547
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0219 0.0738
Echinococcus multilocularis carboxylesterase 5A 0.0153 0.2972 1
Schistosoma mansoni loxhd1 0.0022 0.0219 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0151 0.1341
Plasmodium falciparum plasmepsin I 0.002 0.0162 0.1688
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Onchocerca volvulus 0.0026 0.0295 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0026 0.0295 0.0993
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0219 0.0738
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0229 0.0229
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.1007 1
Giardia lamblia Kinase, AGC PKA 0.0021 0.0186 0.5
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.002 0.0162 0.1458
Loa Loa (eye worm) hypothetical protein 0.002 0.0162 0.0547
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.1007 0.1007
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0406 0.1366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0795 0.2675
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0305 0.1027
Brugia malayi Carboxylesterase family protein 0.0026 0.0295 0.0993
Plasmodium falciparum plasmepsin III 0.002 0.0162 0.1688
Brugia malayi aspartic protease BmAsp-1, identical 0.002 0.0162 0.0547
Toxoplasma gondii AGC kinase 0.0031 0.0406 0.3635
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0449 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Echinococcus granulosus BC026374 protein S09 family 0.0026 0.0295 0.0993
Loa Loa (eye worm) carboxylesterase 0.0026 0.0295 0.0993
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0795 0.0795
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0795 0.2675
Brugia malayi Carboxylesterase family protein 0.0026 0.0295 0.0993
Trypanosoma cruzi Protein kinase B 0.0023 0.0229 0.0525
Onchocerca volvulus 0.0026 0.0295 1
Schistosoma mansoni gliotactin 0.0026 0.0295 0.0295
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Onchocerca volvulus 0.002 0.0162 0.5505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0219 0.0738
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0151 0.5
Plasmodium vivax aspartyl protease, putative 0.002 0.0162 0.1688
Echinococcus granulosus para nitrobenzyl esterase 0.0026 0.0295 0.0993
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0295 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0026 0.0295 0.0295
Brugia malayi hypothetical protein 0.0022 0.0219 0.0738
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0305 0.2903
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0.0295 0.28
Echinococcus multilocularis neuroligin 0.0026 0.0295 0.0993
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.1007 0.3387
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0229 0.0525
Loa Loa (eye worm) carboxylesterase 0.0026 0.0295 0.0993
Plasmodium vivax aspartyl protease, putative 0.002 0.0162 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1007 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0449 0.1511
Echinococcus multilocularis acetylcholinesterase 0.0153 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.2972 1
Toxoplasma gondii aspartyl protease ASP3 0.002 0.0162 0.0165
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.002 0.0162 0.0547
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Brugia malayi Carboxylesterase family protein 0.0153 0.2972 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0305 0.2903
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Brugia malayi hypothetical protein 0.002 0.0162 0.0547
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Schistosoma mansoni acetylcholinesterase 0.0026 0.0295 0.0295
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0219 0.0738
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0406 0.1366
Schistosoma mansoni hypothetical protein 0.0022 0.0219 0.0219
Loa Loa (eye worm) aspartyl protease 6 0.002 0.0162 0.0547
Schistosoma mansoni polycystin 1-related 0.0022 0.0219 0.0219
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.002 0.0162 0.0165
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Brugia malayi hypothetical protein 0.002 0.0162 0.0547
Loa Loa (eye worm) aspartic protease BmAsp-1 0.002 0.0162 0.0547
Toxoplasma gondii aspartyl protease 0.002 0.0162 0.0165
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Plasmodium vivax plasmepsin V, putative 0.002 0.0162 0.1688
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0219 0.0738
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0219 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0219 0.0738
Loa Loa (eye worm) carboxylesterase 0.0153 0.2972 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0449 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Mycobacterium ulcerans carboxylesterase, LipT 0.0026 0.0295 1
Plasmodium falciparum plasmepsin V 0.002 0.0162 0.1688
Echinococcus granulosus neuroligin 0.0026 0.0295 0.0993
Onchocerca volvulus 0.0022 0.0219 0.7431
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0.0295 0.28
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0229 0.164
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0026 0.0295 0.0993
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0186 0.0627
Mycobacterium tuberculosis Carboxylesterase LipT 0.0026 0.0295 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0.0295 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0305 0.1027
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.1007 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0295 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0795 0.0795
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Onchocerca volvulus 0.0026 0.0295 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0186 0.5164
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Echinococcus multilocularis acetylcholinesterase 0.0153 0.2972 1
Plasmodium falciparum plasmepsin IX 0.002 0.0162 0.1688
Brugia malayi Carboxylesterase family protein 0.0026 0.0295 0.0993
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Echinococcus granulosus acetylcholinesterase 0.0153 0.2972 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0186 0.5164
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0162 0.0547
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0607 0.5952
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.0508
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0229 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0852 0.8438
Plasmodium falciparum plasmepsin II 0.002 0.0162 0.1688
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0181 0.061
Echinococcus granulosus carboxylesterase 5A 0.0153 0.2972 1
Plasmodium falciparum plasmepsin IV 0.002 0.0162 0.1688
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0305 0.1027
Brugia malayi Carboxylesterase family protein 0.0026 0.0295 0.0993
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0607 0.5124
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0186 0.0627
Plasmodium falciparum plasmepsin VII 0.002 0.0162 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0852 0.8438
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0229 0.0772
Onchocerca volvulus 0.0022 0.0219 0.7431
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Schistosoma mansoni lipoxygenase 0.0022 0.0219 0.0219
Brugia malayi Doublecortin family protein 0.0022 0.0219 0.0738
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.0162 0.0162
Brugia malayi Carboxylesterase family protein 0.0153 0.2972 1
Onchocerca volvulus 0.002 0.0162 0.5505
Toxoplasma gondii aspartyl protease ASP1 0.002 0.0162 0.0165
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0305 0.1027
Echinococcus multilocularis RUN 0.0022 0.0219 0.0738
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0153 0.2972 0.2972
Toxoplasma gondii hypothetical protein 0.0052 0.0852 1
Onchocerca volvulus 0.0026 0.0295 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.2972 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0449 0.4357
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0162 0.0162
Echinococcus multilocularis nervana 2 0.002 0.0181 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0852 0.8438
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.002 0.0162 0.0547
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.002 0.0162 0.0165
Echinococcus multilocularis BC026374 protein (S09 family) 0.0026 0.0295 0.0993
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.1007 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.1007 1
Brugia malayi hypothetical protein 0.0022 0.0219 0.0738
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0295 0.0295
Echinococcus granulosus nervana 2 0.002 0.0181 0.061
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Plasmodium falciparum plasmepsin VIII, putative 0.002 0.0162 0.1688
Onchocerca volvulus 0.0026 0.0295 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0795 0.0795
Echinococcus granulosus acetylcholinesterase 0.0153 0.2972 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.1007 0.3387
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0219 0.0738
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.0162 0.0162
Echinococcus granulosus nervana 2 0.002 0.0181 0.061
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0449 0.1511
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0181 0.061
Plasmodium falciparum plasmepsin VI 0.002 0.0162 0.1688
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0607 0.5952
Plasmodium vivax aspartyl protease, putative 0.002 0.0162 0.1688
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0181 0.061
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0229 0.0772
Schistosoma mansoni rab6-interacting 0.0022 0.0219 0.0219
Plasmodium vivax aspartyl proteinase, putative 0.002 0.0162 0.1688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0795 0.2675
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0026 0.0295 0.0295
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0795 0.2675
Loa Loa (eye worm) acetylcholinesterase 1 0.0153 0.2972 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0186 0.0627
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0181 0.061
Plasmodium vivax aspartyl proteinase, putative 0.002 0.0162 0.1688
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.1007 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.002 0.0162 0.0547
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0219 0.0738
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0162 0.0547
Loa Loa (eye worm) hypothetical protein 0.0026 0.0295 0.0993
Entamoeba histolytica protein kinase, putative 0.0031 0.0406 0.836
Plasmodium falciparum plasmepsin X 0.002 0.0162 0.1688
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0305 0.0305

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.847 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.81 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.759 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.734 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.701 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.647 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.532 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.421 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.344 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.329 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.293 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.