TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.441 | Formula: C24H22N2O6
H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(CNC(=O)C2Oc3c(C2)c(ccn3)c2ccc3c(c2)OCO3)ccc1OC
InChi: 1S/C24H22N2O6/c1-28-18-5-3-14(9-20(18)29-2)12-26-23(27)22-11-17-16(7-8-25-24(17)32-22)15-4-6-19-21(10-15)31-13-30-19/h3-10,22H,11-13H2,1-2H3,(H,26,27)
InChiKey: NFZPVCYINDURLZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin b	0.0115	0.1036	0.0518
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0621	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0621	1	1
Brugia malayi	hypothetical protein	0.0182	0.2239	0.2239
Echinococcus granulosus	cathepsin L	0.032	0.467	0.4362
Brugia malayi	Cathepsin L-like precursor	0.0415	0.6366	0.6366
Brugia malayi	Cathepsin L-like precursor	0.0621	1	1
Toxoplasma gondii	cathepsin B	0.0115	0.1036	0.0518
Trypanosoma cruzi	cysteine proteinase, putative	0.032	0.467	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0621	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.1036	0.1036
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0115	0.1036	0.1036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0621	1	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0087	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0546	0.0546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Brugia malayi	Fibulin-1 precursor	0.0087	0.0546	0.0546
Leishmania major	cathepsin L-like protease	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.6366	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.032	0.467	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0621	1	1
Loa Loa (eye worm)	cathepsin B	0.0115	0.1036	0.1036
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0115	0.1036	0.0518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Plasmodium vivax	vivapain-2	0.0621	1	1
Plasmodium vivax	vivapain-3	0.032	0.467	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2642	0.2642
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0621	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Echinococcus granulosus	cathepsin b	0.0115	0.1036	0.0518
Brugia malayi	Calcium binding EGF domain containing protein	0.0087	0.0546	0.0546
Entamoeba histolytica	cysteine proteinase 2	0.032	0.467	0.4054
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Entamoeba histolytica	cysteine proteinase 1, putative	0.032	0.467	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0115	0.1036	0.0518
Schistosoma mansoni	cathepsin S (C01 family)	0.0115	0.1036	0.0518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0621	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0415	0.6366	0.5946
Giardia lamblia	Cathepsin L-like protease	0.0115	0.1036	0.5
Giardia lamblia	Hypothetical protein	0.0115	0.1036	0.5
Giardia lamblia	Cysteine protease	0.0115	0.1036	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.467	0.4054
Onchocerca volvulus		0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.467	0.4362
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0415	0.6366	0.6366
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Echinococcus multilocularis	cathepsin L	0.0115	0.1036	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Leishmania major	cathepsin L-like protease	0.0621	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0415	0.6366	0.6366
Leishmania major	cathepsin L-like protease	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.0621	1	1
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.467	0.4362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.467	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0415	0.6366	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Leishmania major	cathepsin L-like protease	0.0621	1	1
Brugia malayi	Cathepsin L-like precursor	0.0205	0.2642	0.2642
Echinococcus multilocularis	cysteine protease	0.0621	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0087	0.0546	0.0546
Echinococcus multilocularis	cathepsin L	0.032	0.467	0.4362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Echinococcus granulosus	cysteine protease	0.032	0.467	0.4362
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0621	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0621	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0115	0.1036	0.1036
Brugia malayi	Cathepsin L-like precursor	0.0621	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0621	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.1036	0.1036
Loa Loa (eye worm)	cysteine protease	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Plasmodium vivax	vivapain-2	0.0621	1	1
Onchocerca volvulus		0.0621	1	1
Onchocerca volvulus		0.0621	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0205	0.2642	0.2642
Brugia malayi	cathepsin F-like cysteine proteinase	0.0115	0.1036	0.1036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Trypanosoma cruzi	cruzipain precursor, putative	0.0205	0.2642	0.1791
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.2642	0.1791
Brugia malayi	cathepsin B-like cysteine proteinase	0.0115	0.1036	0.1036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Giardia lamblia	Cysteine protease	0.0115	0.1036	0.5
Onchocerca volvulus		0.0182	0.2239	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0415	0.6366	0.6366
Brugia malayi	Papain family cysteine protease containing protein	0.032	0.467	0.467
Loa Loa (eye worm)	hypothetical protein	0.0182	0.2239	0.2239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Onchocerca volvulus		0.0115	0.1036	0.0518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0205	0.2642	0.2642
Plasmodium falciparum	cysteine proteinase falcipain 1	0.032	0.467	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Leishmania major	cysteine peptidase A (CPA)	0.0621	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0621	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1036	0.5
Giardia lamblia	Cysteine protease	0.0115	0.1036	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.032	0.467	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0621	1	1
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2642	0.2642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Onchocerca volvulus		0.0621	1	1
Schistosoma mansoni	cathepsin C	0.0115	0.1036	0.0518
Schistosoma mansoni	cathepsin s	0.0205	0.2642	0.2216
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1036	0.5
Giardia lamblia	Encystation-specific protease	0.0115	0.1036	0.5
Echinococcus granulosus	cathepsin b	0.0115	0.1036	0.0518
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Onchocerca volvulus		0.0415	0.6366	0.6156
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.032	0.467	0.467
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0621	1	1
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Echinococcus granulosus	geminin	0.019	0.2381	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0415	0.6366	0.6366
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1036	0.1036
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0087	0.0546	0.0546
Onchocerca volvulus	Cathepsin F homolog	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Onchocerca volvulus		0.0621	1	1
Toxoplasma gondii	cathepsin CPC1	0.0115	0.1036	0.0518
Schistosoma mansoni	cathepsin F (C01 family)	0.0415	0.6366	0.6156
Brugia malayi	Papain family cysteine protease containing protein	0.0621	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0115	0.1036	0.1036
Trypanosoma cruzi	cysteine peptidase, putative	0.0621	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.032	0.467	0.4362
Trypanosoma cruzi	cysteine proteinase, putative	0.032	0.467	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.032	0.467	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0115	0.1036	0.0518
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Echinococcus granulosus	cathepsin l1	0.0415	0.6366	0.6156
Toxoplasma gondii	cathepsin CPL	0.0621	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.032	0.467	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.032	0.467	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Brugia malayi	Cathepsin L-like precursor	0.0415	0.6366	0.6366
Brugia malayi	cathepsin L-like cysteine proteinase	0.0115	0.1036	0.1036
Echinococcus multilocularis	cysteine protease	0.0621	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0115	0.1036	0.0518
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0115	0.1036	0.5
Plasmodium vivax	vivapain-1	0.032	0.467	0.4054
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0621	1	1
Echinococcus multilocularis	geminin	0.019	0.2381	0.1941
Leishmania major	cathepsin L-like protease	0.0621	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Brugia malayi	fibroinase precursor	0.0115	0.1036	0.1036
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Trypanosoma cruzi	cysteine protease, putative	0.032	0.467	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.1036	0.0518
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0621	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0621	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Giardia lamblia	Cathepsin L-like protease	0.0115	0.1036	0.5
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.467	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0115	0.1036	0.0518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1036	0.1036
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0115	0.1036	0.0518
Giardia lamblia	Cysteine protease	0.0115	0.1036	0.5
Brugia malayi	cathepsin L-like precursor	0.0415	0.6366	0.6366
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0205	0.2642	0.2642
Echinococcus granulosus	cathepsin l1	0.0621	1	1
Brugia malayi	cathepsin L precursor	0.0115	0.1036	0.1036
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0115	0.1036	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0115	0.1036	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2642	0.2642
Echinococcus multilocularis	cathepsin b	0.0115	0.1036	0.0518
Entamoeba histolytica	cysteine proteinase, putative	0.0621	1	1
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Onchocerca volvulus		0.0621	1	1
Plasmodium vivax	unspecified product	0.032	0.467	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1036	0.1036
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0621	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0621	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.467	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0621	1	1
Onchocerca volvulus		0.0621	1	1
Loa Loa (eye worm)	fibroinase	0.0621	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0115	0.1036	0.1036
Schistosoma mansoni	hypothetical protein	0.019	0.2381	0.1941
Plasmodium vivax	unspecified product	0.0205	0.2642	0.1791
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.467	0.4362
Toxoplasma gondii	cathepsin CPC2	0.0115	0.1036	0.0518
Echinococcus granulosus	cathepsin L	0.0115	0.1036	0.0518
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0546	0.0546
Giardia lamblia	Hypothetical protein	0.0115	0.1036	0.5
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0087	0.0546	0.0546
Giardia lamblia	Cathepsin L precursor	0.0115	0.1036	0.5
Giardia lamblia	Cathepsin B precursor	0.0115	0.1036	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.1036	0.1036
Leishmania major	cathepsin L-like protease	0.0621	1	1
Loa Loa (eye worm)	ctsf protein	0.0621	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.6366	0.5946
Leishmania major	cathepsin L-like protease	0.0621	1	1
Entamoeba histolytica	cysteine protease, putative	0.032	0.467	0.4054
Leishmania major	cathepsin L-like protease	0.0621	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0621	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0115	0.1036	0.0518
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.032	0.467	0.4054
Schistosoma mansoni	hypothetical protein	0.019	0.2381	0.1941

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2000520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1651171