Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | vivapain-3 | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2871 | 0.2871 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.012 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0062 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.012 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.004 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0062 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin s | 0.004 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.008 | 0.5946 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.012 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.012 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2871 | 0.2871 |
Entamoeba histolytica | cysteine proteinase, putative | 0.008 | 0.5946 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 1 | 1 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Giardia lamblia | Hypothetical protein | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.012 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.004 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | ctsf protein | 0.012 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.004 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2871 | 0.2871 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1247 | 0.1247 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.012 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.004 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2871 | 0.2871 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1247 | 0.1247 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Plasmodium vivax | vivapain-2 | 0.012 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cysteine protease | 0.012 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.004 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.008 | 0.5946 | 0.5946 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | cathepsin L-like precursor | 0.008 | 0.5946 | 0.5946 |
Onchocerca volvulus | 0.012 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.008 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.008 | 0.5946 | 0.5946 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1791 | 0.1791 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1247 | 0.1247 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.4054 | 0.4054 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0062 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.012 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0062 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.008 | 0.5946 | 0.5946 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.008 | 0.5946 | 0.5946 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 1 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.004 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0062 | 0.4054 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0062 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.012 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0022 | 0 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0062 | 0.4054 | 0.4054 |
Giardia lamblia | Encystation-specific protease | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0062 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.004 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5946 | 0.5946 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.008 | 0.5946 | 0.5946 |
Giardia lamblia | Hypothetical protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.008 | 0.5946 | 0.5946 |
Giardia lamblia | Cysteine protease | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0022 | 0 | 0.5 |
Giardia lamblia | Cathepsin L precursor | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.012 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0062 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.008 | 0.5946 | 0.5946 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.