Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.0125 | 0.0117 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8465 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.8465 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.8465 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.8465 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8465 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.8465 | 1 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0687 | 0.0769 | 0.0761 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0687 | 0.0769 | 0.1975 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8465 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.3305 | 0.3877 | 0.3872 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3305 | 0.3877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0154 | 0.0146 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.0154 | 0.0377 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.8465 | 1 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0687 | 0.0769 | 0.1967 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3305 | 0.3877 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0008 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0154 | 0.0146 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.8465 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.0154 | 0.0387 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.0125 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.8465 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3305 | 0.3877 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.8465 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.8465 | 1 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.0125 | 0.0302 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.8465 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.012 | 0.03 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3305 | 0.3877 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.0125 | 0.0117 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8465 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0008 | 0.001 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3305 | 0.3877 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -9 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.