Detailed information for compound 1651445

Basic information

Technical information
  • TDR Targets ID: 1651445
  • Name: (4-bromophenyl)methyl 2-morpholin-4-yl-5-nitr obenzoate
  • MW: 421.242 | Formula: C18H17BrN2O5
  • H donors: 0 H acceptors: 3 LogP: 3.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)COC(=O)c1cc(ccc1N1CCOCC1)[N+](=O)[O-]
  • InChi: 1S/C18H17BrN2O5/c19-14-3-1-13(2-4-14)12-26-18(22)16-11-15(21(23)24)5-6-17(16)20-7-9-25-10-8-20/h1-6,11H,7-10,12H2
  • InChiKey: ACTXKHIAINLIJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-bromophenyl)methyl 2-morpholino-5-nitro-benzoate
  • 2-morpholino-5-nitrobenzoic acid (4-bromophenyl)methyl ester
  • 2-morpholino-5-nitro-benzoic acid (4-bromobenzyl) ester
  • (4-bromophenyl)methyl 2-morpholin-4-yl-5-nitro-benzoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0696 0.0696
Schistosoma mansoni coup transcription factor 0.0137 0.1988 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0612 0.3077
Brugia malayi steroid hormone receptor 0.0137 0.1988 0.1988
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0971 0.4886
Echinococcus granulosus tar DNA binding protein 0.0076 0.0971 0.4886
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Brugia malayi TAR-binding protein 0.0076 0.0971 0.0971
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1739 0.1739
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0137 0.1988 1
Brugia malayi nuclear receptor RXR 0.0122 0.1739 0.1739
Echinococcus granulosus FTZ F1 alpha 0.0137 0.1988 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0137 0.1988 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0612 0.0612
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0137 0.1988 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0137 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0137 0.1988 0.1988
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0971 0.4886
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1739 0.1739
Brugia malayi RNA binding protein 0.0076 0.0971 0.0971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0137 0.1988 0.1988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.1988 0.1988
Brugia malayi Nuclear hormone receptor-like 1 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.061 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0137 0.1988 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0137 0.1988 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0137 0.1988 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0192 1
Brugia malayi Nuclear hormone receptor-like 1 0.0122 0.1739 0.1739
Schistosoma mansoni retinoic acid receptor RXR 0.0137 0.1988 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0612 0.3077
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Brugia malayi photoreceptor-specific nuclear receptor 0.0137 0.1988 0.1988
Echinococcus granulosus ecdysone induced protein 78C 0.0137 0.1988 1
Onchocerca volvulus 0.0182 0.2764 0.0969
Brugia malayi nuclear hormone receptor 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.0122 0.1739 0.1739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.1988 0.1988
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0612 0.3077
Brugia malayi nuclear receptor NHR-88 0.0137 0.1988 0.1988
Loa Loa (eye worm) RNA binding protein 0.0076 0.0971 0.0971
Brugia malayi Nuclear hormone receptor-like 1 0.0122 0.1739 0.1739
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0137 0.1988 0.1988
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1988 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.1988 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.1988 1
Loa Loa (eye worm) steroid hormone receptor 0.0137 0.1988 0.1988
Brugia malayi hypothetical protein 0.002 0.001 0.001
Echinococcus multilocularis FTZ F1 alpha 0.0137 0.1988 1
Schistosoma mansoni RAR-like nuclear receptor 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.2764 0.2764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0612 0.0612
Leishmania major hypothetical protein, conserved 0.003 0.0192 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0137 0.1988 0.1988
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0137 0.1988 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0192 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.1988 0.1988
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.1988 0.1988
Brugia malayi hypothetical protein 0.0122 0.1739 0.1739
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0122 0.1739 0.8747
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0137 0.1988 0.1988
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.1988 0.1988
Brugia malayi hypothetical protein 0.003 0.0192 0.0192
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0137 0.1988 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0612 0.3077
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0971 0.0971
Echinococcus multilocularis ecdysone induced protein 78C 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0137 0.1988 0.1988
Brugia malayi hypothetical protein 0.0122 0.1739 0.1739
Brugia malayi Steroid receptor seven-up type 2 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.006 0.0696 0.0696
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Schistosoma mansoni steroid hormone receptor ad4bp 0.0137 0.1988 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.0122 0.1739 0.1739
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0122 0.1739 0.8747
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0971 0.4886
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0971 0.4886
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0137 0.1988 0.1988
Loa Loa (eye worm) hypothetical protein 0.0122 0.1739 0.1739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0137 0.1988 0.1988
Brugia malayi hypothetical protein 0.0182 0.2764 0.2764
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0137 0.1988 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0971 0.4886
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0373
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0971 0.0971
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0373 0.0373
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0137 0.1988 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0612 0.3077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0137 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1988 0.1988
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0122 0.1739 0.8747
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0192 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0137 0.1988 0.1988
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0137 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0137 0.1988 0.1988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0137 0.1988 0.1988
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0192 1
Onchocerca volvulus Bile acid receptor homolog 0.061 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0192 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0696 0.0696
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0122 0.1739 0.8747
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0696 0.0696
Schistosoma mansoni thyroid hormone receptor 0.0137 0.1988 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0122 0.1739 0.1739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0612 0.3077
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0192 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0192 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0137 0.1988 0.1988
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0612 0.3077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.1988 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0137 0.1988 0.1988
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0971 0.4886
Schistosoma mansoni hypothetical protein 0.0041 0.0373 0.1878

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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