Detailed information for compound 1651735

Basic information

Technical information
  • TDR Targets ID: 1651735
  • Name: (3,4-dimethoxyphenyl)-[3-(4-ethylpiperazin-1- yl)quinoxalin-2-yl]methanone
  • MW: 406.478 | Formula: C23H26N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1nc2ccccc2nc1C(=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C23H26N4O3/c1-4-26-11-13-27(14-12-26)23-21(24-17-7-5-6-8-18(17)25-23)22(28)16-9-10-19(29-2)20(15-16)30-3/h5-10,15H,4,11-14H2,1-3H3
  • InChiKey: NJMQNWWPRZUHIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3,4-dimethoxyphenyl)-[3-(4-ethyl-1-piperazinyl)-2-quinoxalinyl]methanone
  • 2-(4-Ethyl)piperazinyl,3-(3',4'-dimethoxy)benzoyl Quinoxaline
  • NSC721605
  • NCI60_041549

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis BC026374 protein (S09 family) 0.0056 0.0789 0.1394
Brugia malayi Serotonin receptor 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine receptor 0.0137 0.2238 0.3951
Brugia malayi Carboxylesterase family protein 0.0056 0.0789 0.1394
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi sulfakinin receptor protein 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.2238 0.3951
Toxoplasma gondii histone lysine-specific demethylase 0.004 0.0517 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Brugia malayi Carboxylesterase family protein 0.0056 0.0789 0.1394
Leishmania major UDP-galactopyranose mutase 0.004 0.0517 0.5524
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0137 0.2238 0.3951
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0444 0.8595
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.2238 0.3951
Echinococcus granulosus g protein coupled receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Schistosoma mansoni histamine h1 receptor 0.0137 0.2238 0.3951
Mycobacterium ulcerans carboxylesterase, LipT 0.0056 0.0789 0.0789
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0517 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0137 0.2238 0.3951
Trichomonas vaginalis spcc417.12 protein, putative 0.0056 0.0789 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0137 0.2238 0.3951
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Brugia malayi AKH receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0127 0.0225
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0444 0.5627
Brugia malayi G protein-coupled receptor F59B2.13 0.0137 0.2238 0.3951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) carboxylesterase 0.0056 0.0789 0.1394
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0517 0.0912
Schistosoma mansoni inositol monophosphatase 0.0036 0.0444 0.0784
Schistosoma mansoni hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0137 0.2238 0.3951
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0137 0.2238 0.3951
Echinococcus granulosus neuroligin 0.0056 0.0789 0.1394
Plasmodium vivax protoporphyrinogen oxidase, putative 0.004 0.0517 1
Loa Loa (eye worm) inositol-1 0.0036 0.0444 0.0784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0127 0.2461
Schistosoma mansoni hypothetical protein 0.0303 0.5181 0.9147
Echinococcus granulosus acetylcholinesterase 0.033 0.5664 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) carboxylesterase 0.033 0.5664 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Schistosoma mansoni amine GPCR 0.0137 0.2238 0.3951
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni acetylcholinesterase 0.0056 0.0789 0.1394
Echinococcus granulosus 7tm_1 domain containing protein 0.0137 0.2238 0.3951
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis orexin receptor type 2 0.0137 0.2238 0.3951
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0127 0.1611
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0936 0.1652
Echinococcus multilocularis snurportin 1 0.0303 0.5181 0.9147
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1856 0.3278
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0207 0.4009
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.2238 0.3951
Schistosoma mansoni amine oxidase 0.004 0.0517 0.0912
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptides capa receptor 0.0137 0.2238 0.3951
Leishmania major importin beta-1 subunit, putative 0.0023 0.0207 0.2215
Schistosoma mansoni myosin xvIII 0.0137 0.2238 0.3951
Echinococcus granulosus 7TM GPCR rhodopsin 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Plasmodium vivax hypothetical protein, conserved 0.004 0.0517 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0789 0.1394
Schistosoma mansoni opsin-like receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.2238 0.3951
Schistosoma mansoni gliotactin 0.0056 0.0789 0.1394
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Brugia malayi follicle stimulating hormone receptor 0.0137 0.2238 0.3951
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0127 0.2864
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Schistosoma mansoni neuropeptide receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis g protein coupled receptor 0.0137 0.2238 0.3951
Schistosoma mansoni amine GPCR 0.0137 0.2238 0.3951
Brugia malayi neuropeptide F receptor 0.0137 0.2238 0.3951
Mycobacterium ulcerans protoporphyrinogen oxidase 0.004 0.0517 0.0517
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.2238 0.3951
Brugia malayi RNA, U transporter 1 0.0081 0.1232 0.2175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0127 0.0127
Echinococcus granulosus G protein coupled receptor 139 0.0137 0.2238 0.3951
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0517 0.0912
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0137 0.2238 0.3951
Brugia malayi Dopamine receptor 0.0137 0.2238 0.3951
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0127 0.1611
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) carboxylesterase 0.0056 0.0789 0.1394
Echinococcus multilocularis sex peptide receptor 0.0137 0.2238 0.3951
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Brugia malayi neuropeptide F receptor 0.0137 0.2238 0.3951
Schistosoma mansoni inositol monophosphatase 0.0036 0.0444 0.0784
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus g protein coupled receptor 0.0137 0.2238 0.3951
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0127 0.0225
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0137 0.2238 0.3951
Schistosoma mansoni ap endonuclease 0.0018 0.0127 0.0225
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0137 0.2238 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0936 0.1652
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0127 0.0137
Echinococcus multilocularis acetylcholinesterase 0.033 0.5664 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0137 0.2238 0.3951
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0169 0.3278
Brugia malayi Serotonin receptor 0.0137 0.2238 0.3951
Schistosoma mansoni neuropeptide receptor 0.0137 0.2238 0.3951
Brugia malayi GnHR receptor homolog 0.0137 0.2238 0.3951
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0444 0.0784
Echinococcus multilocularis g-protein coupled receptor 0.0137 0.2238 0.3951
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Echinococcus granulosus biogenic amine 5HT receptor 0.0137 0.2238 0.3951
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.004 0.0517 1
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.0517 0.0912
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0137 0.2238 0.3951
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0936 0.0936
Brugia malayi ORL1-like opioid receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0056 0.0789 0.3528
Entamoeba histolytica Ran family GTPase 0.0021 0.0169 0.3814
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0127 0.2461
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0056 0.0789 0.1394
Schistosoma mansoni opsin-like receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis carboxylesterase 5A 0.033 0.5664 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.004 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium ulcerans dehydrogenase 0.004 0.0517 0.0517
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0056 0.0789 0.3528
Loa Loa (eye worm) TYRA-2 protein 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine (5HT) receptor 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.3814
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0137 0.2238 0.3951
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.004 0.0517 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0207 0.2625
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0303 0.6811
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0517 0.0557
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0444 0.0444
Echinococcus granulosus BC026374 protein S09 family 0.0056 0.0789 0.1394
Leishmania major GTP-binding protein, putative 0.0021 0.0169 0.1811
Onchocerca volvulus 0.0056 0.0789 0.3528
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus dro:myosuppressin receptor 0.0137 0.2238 0.3951
Brugia malayi Carboxylesterase family protein 0.0056 0.0789 0.1394
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) acetylcholinesterase 1 0.033 0.5664 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.3278
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.2238 0.3951
Echinococcus multilocularis para nitrobenzyl esterase 0.0056 0.0789 0.1394
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0533 0.9282 1
Schistosoma mansoni hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0127 0.0225
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0127 0.0225
Chlamydia trachomatis protoporphyrinogen oxidase 0.004 0.0517 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0303 0.0534
Schistosoma mansoni amine oxidase 0.004 0.0517 0.0912
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0789 0.1394
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.0517 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0137 0.2238 0.3951
Brugia malayi putative neuropeptide receptor NPR1 0.0137 0.2238 0.3951
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.5181 0.9147
Schistosoma mansoni Lysine-specific histone demethylase 1 0.004 0.0517 0.0912
Schistosoma mansoni ran 0.0021 0.0169 0.0299
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0444 0.5627
Echinococcus granulosus allatostatin A receptor 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Brugia malayi RE15519p 0.0137 0.2238 0.3951
Onchocerca volvulus Neuropeptide F receptor homolog 0.0137 0.2238 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0936 0.1008
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0517 0.0557
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0137 0.2238 0.3951
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0137 0.2238 0.3951
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0169 0.0299
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0303 0.0534
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus multilocularis G protein coupled receptor 139 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0127 0.7508
Echinococcus granulosus snurportin 1 0.0303 0.5181 0.9147
Echinococcus multilocularis neuroligin 0.0056 0.0789 0.1394
Echinococcus granulosus sex peptide receptor 0.0137 0.2238 0.3951
Brugia malayi Melatonin receptor type 1A 0.0137 0.2238 0.3951
Mycobacterium tuberculosis Carboxylesterase LipT 0.0056 0.0789 0.0851
Brugia malayi G protein-coupled receptor 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Echinococcus multilocularis neuropeptide Y receptor 0.0137 0.2238 0.3951
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0574 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0444 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0207 0.2625
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0137 0.2238 0.3951
Schistosoma mansoni BC026374 protein (S09 family) 0.0056 0.0789 0.1394
Brugia malayi Dopamine receptor protein 1 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Echinococcus multilocularis serotonin receptor 0.0137 0.2238 0.3951
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0137 0.2238 0.3951
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0789 0.0851
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Echinococcus multilocularis serotonin receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis g protein coupled receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Brugia malayi G-protein coupled receptor 0.0137 0.2238 0.3951
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0376 0.7285
Brugia malayi larval opioid receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Schistosoma mansoni biogenic amine receptor 0.0137 0.2238 0.3951
Schistosoma mansoni hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Echinococcus granulosus somatostatin receptor 0.0137 0.2238 0.3951
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0444 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0303 0.5854
Echinococcus granulosus biogenic amine 5HT receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0056 0.0789 0.3528
Echinococcus multilocularis neuropeptide s receptor 0.0137 0.2238 0.3951
Schistosoma mansoni biogenic amine (5HT) receptor 0.0137 0.2238 0.3951
Mycobacterium ulcerans monoamine oxidase 0.004 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0789 0.0851
Echinococcus multilocularis neuropeptide receptor A26 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Brugia malayi MH2 domain containing protein 0.0116 0.1856 0.3278
Onchocerca volvulus 0.0137 0.2238 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptide receptor 0.0137 0.2238 0.3951
Brugia malayi Tachykinin-like peptides receptor 99D 0.0137 0.2238 0.3951
Echinococcus granulosus fmrfamide receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis 0.004 0.0517 0.0912
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1856 0.3278
Echinococcus multilocularis protoporphyrinogen oxidase 0.004 0.0517 0.0912
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Loa Loa (eye worm) melatonin receptor type 1A 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0137 0.2238 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Trichomonas vaginalis ran, putative 0.0021 0.0169 0.2146
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis fmrfamide receptor 0.0137 0.2238 0.3951
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.004 0.0517 1
Echinococcus multilocularis somatostatin receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0734 0.1296
Echinococcus granulosus carboxylesterase 5A 0.033 0.5664 1
Echinococcus multilocularis neuropeptide receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis allatostatin A receptor 0.0137 0.2238 0.3951
Entamoeba histolytica hypothetical protein 0.0023 0.0207 0.4664
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.2238 0.3951
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0127 0.136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.2238 0.3951
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0137 0.2238 0.3951
Onchocerca volvulus 0.0056 0.0789 0.3528
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.2238 0.3951
Plasmodium falciparum importin beta, putative 0.0028 0.0303 0.5854
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni neuropeptide F-like receptor 0.0137 0.2238 0.3951
Echinococcus granulosus orexin receptor type 2 0.0137 0.2238 0.3951
Echinococcus multilocularis acetylcholinesterase 0.033 0.5664 1
Brugia malayi G-protein coupled receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.033 0.5664 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0789 0.1394
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0056 0.0789 0.1394
Echinococcus granulosus importin subunit beta 1 0.0028 0.0303 0.0534
Echinococcus multilocularis dro:myosuppressin receptor 0.0137 0.2238 0.3951
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0137 0.2238 0.3951
Echinococcus granulosus g protein coupled receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi Carboxylesterase family protein 0.033 0.5664 1
Schistosoma mansoni neuropeptide receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis fmrfamide receptor 0.0137 0.2238 0.3951
Schistosoma mansoni ap endonuclease 0.0018 0.0127 0.0225
Brugia malayi Importin beta-1 subunit 0.0028 0.0303 0.0534
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis neuropeptide receptor 0.0137 0.2238 0.3951
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0137 0.2238 0.3951
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0127 0.2864
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0936 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0127 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptide receptor A26 0.0137 0.2238 0.3951
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0137 0.2238 0.3951
Brugia malayi Carboxylesterase family protein 0.0056 0.0789 0.1394
Schistosoma mansoni neuroligin 3 (S09 family) 0.0056 0.0789 0.1394
Echinococcus granulosus neuropeptide FF receptor 2 0.0137 0.2238 0.3951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.2238 0.3951
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0936 0.0936
Brugia malayi Inositol-1 0.0036 0.0444 0.0784
Echinococcus multilocularis g protein coupled receptor 0.0137 0.2238 0.3951
Schistosoma mansoni amine GPCR 0.0137 0.2238 0.3951
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0444 0.8595
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0137 0.2238 0.3951
Echinococcus granulosus hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0127 0.2461
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Schistosoma mansoni ran 0.0021 0.0169 0.0299
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Plasmodium falciparum protoporphyrinogen oxidase 0.004 0.0517 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0137 0.2238 0.3951
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi hypothetical protein 0.0056 0.0789 0.1394
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi putative neuropeptide receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0169 0.0299
Echinococcus granulosus g-protein coupled receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0444 0.0784
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0137 0.2238 0.3951
Brugia malayi Carboxylesterase family protein 0.033 0.5664 1
Schistosoma mansoni amine GPCR 0.0137 0.2238 0.3951
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0444 1
Echinococcus granulosus serotonin receptor 0.0137 0.2238 0.3951
Echinococcus granulosus para nitrobenzyl esterase 0.0056 0.0789 0.1394
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0169 0.3278
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.0299
Echinococcus multilocularis neuropeptide FF receptor 2 0.0137 0.2238 0.3951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0444 0.5627
Echinococcus granulosus rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0137 0.2238 0.3951
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0127 0.2864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0137 0.2238 0.3951
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0936 0.1652
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.0299
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0056 0.0789 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0056 0.0789 0.1394
Brugia malayi hypothetical protein 0.004 0.0517 0.0912
Onchocerca volvulus 0.0137 0.2238 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0303 0.5854
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Mycobacterium ulcerans oxidoreductase 0.004 0.0517 0.0517
Brugia malayi hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Schistosoma mansoni alpha-1 adrenergic receptor 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptide s receptor 0.0137 0.2238 0.3951
Schistosoma mansoni neuropeptide receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.004 0.0517 0.0912
Echinococcus granulosus neuropeptide receptor 0.0137 0.2238 0.3951
Brugia malayi Dopamine receptor protein 2 0.0137 0.2238 0.3951
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.004 0.0517 0.0912
Echinococcus multilocularis lysine specific histone demethylase 1A 0.004 0.0517 0.0912
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0137 0.2238 0.3951
Schistosoma mansoni growth hormone secretagogue receptor 0.0137 0.2238 0.3951
Echinococcus granulosus peptide allatostatin:somatostatin 0.0137 0.2238 0.3951
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.033 0.5664 1
Schistosoma mansoni importin beta-1 0.0028 0.0303 0.0534
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.2238 0.3951
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.3278
Schistosoma mansoni amine GPCR 0.0137 0.2238 0.3951
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0207 0.2625
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Brugia malayi SWIRM domain containing protein 0.004 0.0517 0.0912
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Loa Loa (eye worm) G-protein coupled receptor 0.0137 0.2238 0.3951
Echinococcus multilocularis neuropeptides capa receptor 0.0137 0.2238 0.3951
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0936 0.1652
Onchocerca volvulus 0.004 0.0517 0.231
Schistosoma mansoni neuropeptide f receptor 76f 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Toxoplasma gondii exonuclease III APE 0.0018 0.0127 0.2461
Echinococcus granulosus acetylcholinesterase 0.033 0.5664 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0376 0.0406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.0137 0.2238 0.3951
Echinococcus granulosus neuropeptide Y receptor 0.0137 0.2238 0.3951
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.3278
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0127 0.2461
Schistosoma mansoni opsin-like receptor 0.0137 0.2238 0.3951
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0303 0.6811
Schistosoma mansoni hypothetical protein 0.0137 0.2238 0.3951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Echinococcus multilocularis rhodopsin orphan GPCR 0.0137 0.2238 0.3951
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0137 0.2238 0.3951
Loa Loa (eye worm) hypothetical protein 0.033 0.5664 1
Onchocerca volvulus 0.0137 0.2238 1
Loa Loa (eye worm) neuropeptide F receptor 0.0137 0.2238 0.3951
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0444 0.4748
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0444 0.8595
Schistosoma mansoni adenoreceptor 0.0137 0.2238 0.3951

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.761 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.126 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.004 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.862 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.614 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.596 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.515 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.376 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.356 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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