Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0727 | 0.6637 | 0.6637 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0081 | 0.0543 | 0.0543 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0418 | 0.0418 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0214 | 0.18 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.1083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | acetylcholinesterase | 0.1083 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0183 | 0.1506 | 1 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | gliotactin | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1083 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1083 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0873 | 0.8019 | 0.8019 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0873 | 0.8019 | 0.8019 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0727 | 0.6637 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0442 | 0.0442 |
Echinococcus granulosus | carboxylesterase 5A | 0.1083 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1083 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | carboxylesterase | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | GPCR, family 2 | 0.0068 | 0.0418 | 0.0418 |
Echinococcus granulosus | GPCR family 2 | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | carboxylesterase | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | carboxylesterase | 0.1083 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0183 | 0.1506 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0214 | 0.18 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.1083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | acetylcholinesterase | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1161 | 0.1161 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.0613 | 0.0613 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | acetylcholinesterase | 0.1083 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0081 | 0.0543 | 0.0543 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0146 | 0.1161 | 0.1161 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0081 | 0.0543 | 0.0543 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0081 | 0.0543 | 0.0543 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | acetylcholinesterase | 0.1083 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | acetylcholinesterase | 0.1083 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0183 | 0.1506 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Carboxylesterase family protein | 0.1083 | 1 | 1 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0068 | 0.0418 | 0.0418 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.0613 | 0.0613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Induction of apoptosis in human HL60 cells assessed as increase in apoptotic cells at 10 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 2.5 /- 0.3%) | ChEMBL. | 22546669 |
IC50 (functional) | = 7 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 22546669 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22546669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.