Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.212 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.212 | 1 | 1 |
Onchocerca volvulus | 0.0358 | 0.0849 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.212 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.212 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.212 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0358 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | carboxylesterase | 0.212 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0358 | 0.0849 | 0.5 |
Onchocerca volvulus | 0.0358 | 0.0849 | 0.5 | |
Onchocerca volvulus | 0.0358 | 0.0849 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0358 | 0.0849 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0358 | 0.0849 | 0.0849 |
Echinococcus granulosus | acetylcholinesterase | 0.212 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0358 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0358 | 0.0849 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0358 | 0.0849 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0358 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.212 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.212 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0358 | 0.0849 | 0.0849 |
Brugia malayi | Carboxylesterase family protein | 0.212 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0358 | 0.0849 | 0.5 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0535 | 0.1766 | 0.1766 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0358 | 0.0849 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0358 | 0.0849 | 0.0849 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0358 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0358 | 0.0849 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0358 | 0.0849 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.212 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.