TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.475 | Formula: C23H24N6O3
H donors: 3 H acceptors: 3 LogP: 3.94 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNC(=O)c1cccc(c1)N/C(=N/c1ccc(c(c1)OC)c1cnco1)/NC#N
InChi: 1S/C23H24N6O3/c1-3-4-10-26-22(30)16-6-5-7-17(11-16)28-23(27-14-24)29-18-8-9-19(20(12-18)31-2)21-13-25-15-32-21/h5-9,11-13,15H,3-4,10H2,1-2H3,(H,26,30)(H2,27,28,29)
InChiKey: JKMGTVKAENOREX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IMP (inosine 5'-monophosphate) dehydrogenase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium knowlesi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium berghei	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Theileria parva	Inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma japonicum	ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma congolense	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium hominis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Loa Loa (eye worm)	IMP dehydrogenase 1	Get druggable targets OG5_126887	All targets in OG5_126887
Babesia bovis	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium yoelii	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Neospora caninum	hypothetical protein	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Toxoplasma gondii	IMP dehydrogenas	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	Get druggable targets OG5_126887	All targets in OG5_126887

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Proteasome A-type and B-type family protein	0.0124	0.0531	0.1508
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0124	0.0531	0.1675
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.0583	0.0524
Trypanosoma cruzi	GMP reductase	0.0095	0.0378	0.1193
Schistosoma mansoni	inhibitor of apoptosis protein	0.0131	0.0565	0.1782
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.005	0.0144	0.0081
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0124	0.0531	0.1675
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0565	0.1782
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0131	0.0565	0.1618
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0124	0.0531	0.1508
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0304	0.1467	0.4519
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0095	0.0378	0.1193
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0304	0.1467	0.3899
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0062	0.0062
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0056	0.0176	0.0554
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0124	0.0531	0.1508
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0124	0.0531	0.0531
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0124	0.0531	0.0547
Onchocerca volvulus	Putative GMP reductase	0.0039	0.009	0.0347
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0491	0.2439	0.7689
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0124	0.0531	0.0645
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0124	0.0531	0.1675
Onchocerca volvulus	Cell death protein 3 homolog	0.006	0.0196	0.1651
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0632	0.3172	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.019	0.0873	0.2607
Brugia malayi	proteasome subunit beta type 2	0.0304	0.1467	0.4519
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0124	0.0531	0.0645
Leishmania major	proteasome beta 2 subunit, putative	0.0124	0.0531	0.1508
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0124	0.0531	0.1675
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0304	0.1467	0.4519
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Onchocerca volvulus	Deterin homolog	0.0131	0.0565	0.6208
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0124	0.0531	1
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1508
Leishmania major	guanosine monophosphate reductase	0.0095	0.0378	0.1017
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0304	0.1467	0.4627
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0124	0.0531	0.1675
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0124	0.0531	0.1508
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0583	0.1838
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.009	0.009
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0491	0.2439	0.2439
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0124	0.0531	0.1508
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0124	0.0531	0.1508
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0131	0.0565	0.1618
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0124	0.0531	0.0645
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0095	0.0378	0.1193
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0124	0.0531	0.0645
Brugia malayi	proteasome subunit alpha type 6	0.0124	0.0531	0.1508
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0095	0.0378	0.0848
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0124	0.0531	0.0645
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Onchocerca volvulus	Notchless protein homolog	0.0124	0.0531	0.5787
Brugia malayi	Kelch motif family protein	0.0056	0.0176	0.0366
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0124	0.0531	0.1675
Toxoplasma gondii	proteasome subunit	0.0124	0.0531	0.0547
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0124	0.0531	0.1675
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0124	0.0531	0.0472
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0124	0.0531	0.1675
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Echinococcus granulosus	netrin receptor unc 5	0.019	0.0873	0.0816
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0124	0.0531	0.1508
Brugia malayi	proteasome subunit alpha type 4	0.0124	0.0531	0.1508
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0124	0.0531	0.1675
Schistosoma mansoni	hypothetical protein	0.0332	0.1614	0.509
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0124	0.0531	0.0547
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0124	0.0531	0.1675
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0124	0.0531	0.1508
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0124	0.0531	0.0531
Loa Loa (eye worm)	aminopeptidase N	0.0034	0.0062	0.0196
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0095	0.0378	0.0773
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0124	0.0531	0.1508
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0124	0.0531	0.0547
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0304	0.1467	0.4627
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0124	0.0531	0.0531
Echinococcus multilocularis	apoptotic protease activating factor 1	0.006	0.0196	0.0196
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Schistosoma mansoni	integrin beta subunit	0.0205	0.0949	0.2993
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0124	0.0531	0.1675
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0124	0.0531	0.1508
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0124	0.0531	0.1675
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0304	0.1467	0.3962
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0124	0.0531	0.0531
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0124	0.0531	0.0645
Echinococcus multilocularis	proteasome subunit beta type 7	0.0124	0.0531	0.0531
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0191	0.0877	0.2765
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0632	0.3172	1
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0124	0.0531	0.1508
Brugia malayi	proteasome subunit beta type 1	0.0491	0.2439	0.7642
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0492	0.1551
Brugia malayi	Protein kinase domain containing protein	0.019	0.0873	0.2607
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0095	0.0378	0.1017
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0124	0.0531	0.1349
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0124	0.0531	0.1508
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0095	0.0378	0.1017
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0491	0.2439	0.7403
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0124	0.0531	0.1675
Schistosoma mansoni	hypothetical protein	0.019	0.0873	0.2751
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.1945	1	1
Echinococcus granulosus	caspase 2	0.006	0.0196	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0583	0.1838
Brugia malayi	Proteasome A-type and B-type family protein	0.0124	0.0531	0.1508
Entamoeba histolytica	hypothetical protein	0.0035	0.0068	0.002
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0124	0.0531	0.1508
Schistosoma mansoni	hypothetical protein	0.0131	0.0565	0.1782
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0124	0.0531	0.0645
Leishmania major	proteasome alpha 1 subunit, putative	0.0124	0.0531	0.1508
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0304	0.1467	0.4519
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0124	0.0531	0.0645
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0124	0.0531	0.0645
Trypanosoma brucei	GMP reductase	0.0095	0.0378	0.1017
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0124	0.0531	0.1675
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0124	0.0531	0.1675
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0124	0.0531	0.0645
Echinococcus multilocularis	caspase 2	0.006	0.0196	0.0196
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0124	0.0531	0.0472
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0124	0.0531	0.0547
Toxoplasma gondii	peptidase, T1 family protein	0.0124	0.0531	0.0547
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0632	0.3172	1
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0124	0.0531	0.1675
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0124	0.0531	0.0531
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0124	0.0531	0.1508
Echinococcus granulosus	proteasome subunit alpha type 6	0.0124	0.0531	0.0472
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0124	0.0531	0.1278
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0062	0.0062
Echinococcus granulosus	Proteasome subunit alpha beta	0.0124	0.0531	0.0472
Brugia malayi	Cell death protein 3 precursor	0.006	0.0196	0.043
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0124	0.0531	0.1508
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0124	0.0531	0.1508
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0089	0.0349	0.0923
Brugia malayi	MH2 domain containing protein	0.0117	0.0492	0.1382
Brugia malayi	Proteasome A-type and B-type family protein	0.0124	0.0531	0.1508
Leishmania major	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1508
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0124	0.0531	0.1675
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0034	0.0062	0.0196
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0124	0.0531	0.1675
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0124	0.0531	0.0645
Brugia malayi	Integrin beta pat-3 precursor	0.0356	0.1735	0.5379
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0124	0.0531	0.0645
Onchocerca volvulus		0.0131	0.0565	0.6208
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0304	0.1467	0.4627
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0124	0.0531	0.0645
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1675
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Brugia malayi	Uncoordinated protein 44	0.019	0.0873	0.2607
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0124	0.0531	0.0531
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0124	0.0531	0.1675
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0304	0.1467	0.4627
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0124	0.0531	0.0472
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0632	0.3172	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0632	0.3172	1
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0124	0.0531	0.1675
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0034	0.0062	0.0196
Echinococcus granulosus	geminin	0.0332	0.1614	0.1562
Giardia lamblia	Proteasome subunit beta type 2	0.0304	0.1467	0.3546
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0124	0.0531	0.1508
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0124	0.0531	0.1675
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0124	0.0531	0.1675
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.019	0.0873	0.0873
Echinococcus granulosus	inhibitor of apoptosis protein	0.0131	0.0565	0.0506
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0124	0.0531	0.1675
Brugia malayi	proteasome subunit alpha type 3	0.0124	0.0531	0.1508
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0124	0.0531	0.1508
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.0378	0.1193
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0124	0.0531	0.1508
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0632	0.3172	1
Leishmania major	proteasome alpha 2 subunit, putative	0.0124	0.0531	0.1508
Leishmania major	proteasome beta 3 subunit, putative	0.0124	0.0531	0.1508
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.0378	0.1193
Mycobacterium ulcerans	proteasome PrcA	0.0124	0.0531	0.1508
Schistosoma mansoni	netrin receptor unc5	0.019	0.0873	0.2751
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0565	0.1782
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0491	0.2439	0.2391
Brugia malayi	Proteasome subunit alpha type 1	0.0124	0.0531	0.1508
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0491	0.2439	0.7689
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.0378	0.1193
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.009	0.009
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0124	0.0531	0.1675
Schistosoma mansoni	hypothetical protein	0.006	0.0196	0.0618
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0632	0.3172	1
Leishmania major	proteasome alpha 3 subunit, putative	0.0124	0.0531	0.1508
Brugia malayi	GMP reductase	0.0039	0.009	0.009
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0124	0.0531	0.0645
Echinococcus granulosus	Ankyrin	0.0191	0.0877	0.082
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0068	0.0216
Leishmania major	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1508
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0124	0.0531	0.0472
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0124	0.0531	0.1675
Echinococcus granulosus	apoptotic protease activating factor 1	0.006	0.0196	0.0135
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0131	0.0565	0.1782
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0095	0.0378	0.1017
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0124	0.0531	0.1675
Leishmania major	proteasome beta 7 subunit, putative	0.0124	0.0531	0.1508
Loa Loa (eye worm)	GMP reductase	0.0039	0.009	0.0285
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0124	0.0531	0.1508
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1675
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0632	0.3172	0.3172
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0124	0.0531	0.0531
Brugia malayi	proteasome subunit alpha type 2	0.0124	0.0531	0.1508
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0124	0.0531	0.1675
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0131	0.0565	0.0506
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0095	0.0378	0.1017
Echinococcus granulosus	proteasome subunit beta t family	0.0124	0.0531	0.0472
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0124	0.0531	0.1508
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0124	0.0531	0.0472
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0304	0.1467	0.1467
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0632	0.3172	1
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0124	0.0531	0.0547
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0124	0.0531	0.1675
Toxoplasma gondii	proteasome subunit beta type, putative	0.0632	0.3172	1
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0124	0.0531	0.0645
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.0583	0.0583
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0124	0.0531	0.0547
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0124	0.0531	0.1508
Echinococcus multilocularis	netrin receptor unc 5	0.019	0.0873	0.0873
Leishmania major	proteasome beta 5 subunit, putative	0.0632	0.3172	1
Echinococcus multilocularis	geminin	0.0332	0.1614	0.1614
Onchocerca volvulus	Netrin receptor homolog	0.019	0.0873	1
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0491	0.2439	0.7642
Toxoplasma gondii	proteasome beta subunit	0.0124	0.0531	0.0547
Echinococcus multilocularis	proteasome subunit beta type 6	0.0124	0.0531	0.0531
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0124	0.0531	0.1508
Entamoeba histolytica	hypothetical protein	0.0035	0.0068	0.002
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0124	0.0531	0.1675
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0124	0.0531	0.0531
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0124	0.0531	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0176	0.0554
Leishmania major	proteasome beta-1 subunit, putative	0.0124	0.0531	0.1508
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0062	0.0062
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0124	0.0531	0.0547
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.0583	0.0524
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0491	0.2439	0.7376
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0124	0.0531	0.1675
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0124	0.0531	0.1675
Brugia malayi	proteasome subunit beta type 3	0.0124	0.0531	0.1508
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0124	0.0531	0.1675
Loa Loa (eye worm)	hypothetical protein	0.006	0.0196	0.0618
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0124	0.0531	0.1675
Brugia malayi	Death domain containing protein	0.019	0.0873	0.2607
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Entamoeba histolytica	hypothetical protein	0.0035	0.0068	0.002
Loa Loa (eye worm)	integrin beta-2	0.0356	0.1735	0.547
Echinococcus multilocularis	integrin beta 2	0.026	0.124	0.124
Trypanosoma brucei	proteasome alpha 7 subunit	0.0124	0.0531	0.1508
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0124	0.0531	0.0645
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0124	0.0531	0.1675
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0124	0.0531	0.1675
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.0583	0.1838
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0095	0.0378	0.0378
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0124	0.0531	0.1508
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0491	0.2439	0.7689
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0304	0.1467	0.3962
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0124	0.0531	0.0531
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0034	0.0062	0.0196
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0491	0.2439	0.7642
Trypanosoma brucei	proteasome beta 7 subunit	0.0124	0.0531	0.1508
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0124	0.0531	0.1675
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0068	0.0006
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0124	0.0531	0.1508
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0124	0.0531	0.1675
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0304	0.1467	0.4519
Entamoeba histolytica	hypothetical protein	0.0035	0.0068	0.002
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0877	0.2765
Schistosoma mansoni	ankyrin 23/unc44	0.019	0.0873	0.2751
Brugia malayi	proteasome subunit alpha type 1	0.0124	0.0531	0.1508
Leishmania major	proteasome beta 2 subunit, putative	0.0304	0.1467	0.4519
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0124	0.0531	0.1675
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0124	0.0531	0.1508
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0124	0.0531	0.1508
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0124	0.0531	0.1508
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0124	0.0531	0.0645
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0124	0.0531	0.1508
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0632	0.3172	1
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0491	0.2439	0.7642
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0632	0.3172	1
Brugia malayi	hypothetical protein	0.006	0.0196	0.043
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0124	0.0531	0.1675
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Echinococcus granulosus	proteasome subunit beta type 6	0.0124	0.0531	0.0472
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1675
Plasmodium falciparum	proteasome subunit beta type-5	0.0632	0.3172	1
Echinococcus multilocularis	aminopeptidase N	0.0034	0.0062	0.0062
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0304	0.1467	0.1414
Echinococcus granulosus	integrin beta 2	0.026	0.124	0.1185
Brugia malayi	hypothetical protein	0.0035	0.0068	0.002
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0124	0.0531	0.1508
Giardia lamblia	Proteasome subunit beta type 1	0.0491	0.2439	0.7224
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0131	0.0565	0.0565
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0492	0.1551
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.019	0.0873	0.2751
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0124	0.0531	0.1675
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0124	0.0531	0.1508
Loa Loa (eye worm)	PAS-3 protein	0.0124	0.0531	0.1675
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0124	0.0531	0.1675
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Trypanosoma cruzi	aminopeptidase, putative	0.0034	0.0062	0.0196
Trypanosoma brucei	proteasome beta 6 subunit	0.0491	0.2439	0.7642
Echinococcus granulosus	proteasome prosome macropain	0.0632	0.3172	0.3129
Plasmodium falciparum	proteasome subunit beta type-4	0.0124	0.0531	0.0645
Leishmania major	proteasome alpha 1 subunit, putative	0.0124	0.0531	0.1508
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0124	0.0531	0.0645
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0491	0.2439	0.7689
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0124	0.0531	0.0645
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.019	0.0873	0.0816
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0632	0.3172	1
Trypanosoma cruzi	20S proteasome subunit	0.0304	0.1467	0.4627
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0491	0.2439	0.7403
Loa Loa (eye worm)	hypothetical protein	0.006	0.0196	0.0618
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0134	0.0583	0.1675
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0124	0.0531	0.1675
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0124	0.0531	0.0645
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0045	0.012	0.0185
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0062	0.0062
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0034	0.0062	0.0196
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0095	0.0378	0.0318
Trypanosoma cruzi	GMP reductase	0.0095	0.0378	0.1193
Schistosoma mansoni	hypothetical protein	0.0035	0.0068	0.0216
Schistosoma mansoni	hypothetical protein	0.0332	0.1614	0.509
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0068	0.0068
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0124	0.0531	0.0645
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0124	0.0531	0.1675
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0124	0.0531	0.0531
Brugia malayi	hypothetical protein	0.0056	0.0176	0.0366
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0632	0.3172	1
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0124	0.0531	0.0531
Brugia malayi	Proteasome subunit alpha type 7-1	0.0124	0.0531	0.1508
Echinococcus granulosus	proteasome subunit alpha type 2	0.0124	0.0531	0.0472
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0134	0.0583	0.1838
Onchocerca volvulus		0.006	0.0196	0.1651
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0124	0.0531	0.1508
Echinococcus multilocularis	Ankyrin	0.0191	0.0877	0.0877
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0124	0.0531	0.0645
Mycobacterium ulcerans	proteasome PrcB	0.0632	0.3172	1
Echinococcus granulosus	death domain containing protein	0.019	0.0873	0.0816
Loa Loa (eye worm)	hypothetical protein	0.019	0.0873	0.2751
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0131	0.0565	0.0565
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0034	0.0062	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.0583	0.0583
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0062	0.0062
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0799	0.404	0.404
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0124	0.0531	0.1508
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0124	0.0531	0.1508
Toxoplasma gondii	heat shock protein hslv, putative	0.0124	0.0531	0.0547
Echinococcus granulosus	proteasome subunit beta type 7	0.0124	0.0531	0.0472
Brugia malayi	20S proteasome alpha5 subunit	0.0124	0.0531	0.1508
Schistosoma mansoni	caspase-7 (C14 family)	0.006	0.0196	0.0618

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.13 uM	In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.	ChEMBL.	12270177
IC50 (binding)	= 0.13 uM	In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.	ChEMBL.	12270177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 165254