Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0071 | 0.3257 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1064 | 0.1064 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1355 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0185 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0071 | 0.3257 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.7273 | 0.7273 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1064 | 0.1064 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.751 | 0.751 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0185 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0185 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1981 | 0.1981 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1981 | 0.1981 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.1561 | 0.1561 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.751 | 0.751 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.1561 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.2125 | 0.2125 |
Brugia malayi | Dihydrofolate reductase | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0415 | 0.0415 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0415 | 0.0415 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0185 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0185 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0071 | 0.3257 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.2125 | 0.2125 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0415 | 0.0415 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0071 | 0.3257 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.751 | 0.751 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.1561 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1355 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0415 | 0.0415 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0071 | 0.3257 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.751 | 0.751 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1981 | 0.1981 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0071 | 0.3257 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1981 | 0.1981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 38.6 uM | Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22537680 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.