Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A1 receptor | 326 aa | 316 aa | 19.3 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 307 aa | 21.2 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 331 aa | 25.7 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 315 aa | 23.8 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 22.1 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 304 aa | 25.3 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 306 aa | 26.1 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A1 receptor | 326 aa | 301 aa | 25.6 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 314 aa | 21.7 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % | |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 296 aa | 22.6 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 24.0 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 277 aa | 23.8 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 326 aa | 20.2 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 318 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0081 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.1509 | 0.6739 | 0.6739 |
Trypanosoma brucei | hexokinase | 0.2213 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.2213 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.2213 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.028 | 0.104 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0119 | 0.0119 |
Brugia malayi | hexokinase type II | 0.0703 | 0.3004 | 0.3004 |
Plasmodium vivax | hexokinase, putative | 0.2213 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2213 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.2213 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.1388 | 0.6178 | 0.6178 |
Trypanosoma cruzi | hexokinase, putative | 0.2213 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.2213 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.028 | 0.104 | 0.104 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0081 | 0.0119 | 0.0119 |
Treponema pallidum | hexokinase (hxk) | 0.2213 | 1 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0081 | 0.0119 | 0.0119 |
Trypanosoma brucei | hexokinase | 0.2213 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.2213 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0081 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.028 | 0.104 | 0.104 |
Echinococcus multilocularis | hexokinase | 0.2213 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.2213 | 1 | 0.5 |
Onchocerca volvulus | 0.2213 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0869 | 0.0869 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0081 | 0.0119 | 0.0119 |
Schistosoma mansoni | hexokinase | 0.2213 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.2213 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0703 | 0.3004 | 0.3004 |
Loa Loa (eye worm) | hexokinase | 0.2213 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.2213 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0703 | 0.3004 | 0.3004 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.028 | 0.104 | 0.104 |
Loa Loa (eye worm) | hexokinase | 0.2213 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0685 | 0.2917 | 0.2917 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0306 | 0.116 | 0.116 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0081 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hexokinase type II | 0.2213 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0261 | 0.0955 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0081 | 0.0119 | 0.0119 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0306 | 0.116 | 0.116 |
Toxoplasma gondii | hexokinase | 0.2213 | 1 | 0.5 |
Onchocerca volvulus | 0.2213 | 1 | 1 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0261 | 0.0955 | 1 |
Echinococcus granulosus | hexokinase | 0.2213 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.2213 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.2213 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.2213 | 1 | 0.5 |
Onchocerca volvulus | 0.2213 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0685 | 0.2917 | 0.2917 |
Loa Loa (eye worm) | hexokinase | 0.1388 | 0.6178 | 0.6178 |
Trypanosoma cruzi | hexokinase, putative | 0.2213 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2213 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 uM | Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane | ChEMBL. | 8071944 |
Ki (binding) | = 1.6 uM | Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane | ChEMBL. | 8071944 |
Ki (binding) | = 21.7 uM | Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane | ChEMBL. | 8071944 |
Ki (binding) | = 21.7 uM | Affinity to A2 adenosine receptor was measured by the displacement of [3H]-CGS- 21680 in bovine brain striatal membrane | ChEMBL. | 8071944 |
Ratio (binding) | = 13 | Ratio between the Ki values of A2 and A1 receptors | ChEMBL. | 8071944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.