Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 4 | 303 aa | 312 aa | 29.8 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hexokinase | 0.1172 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1172 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0065 | 0.0056 |
Echinococcus multilocularis | hexokinase | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0065 | 0.0056 |
Leishmania major | hexokinase, putative | 0.1172 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.3073 | 0.3067 |
Brugia malayi | Hexokinase family protein | 0.0363 | 0.2987 | 0.2941 |
Trypanosoma brucei | hexokinase | 0.1172 | 1 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0053 | 0.0301 | 0.0238 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0065 | 1 |
Leishmania major | hexokinase, putative | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 0.6771 | 0.6768 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0065 | 1 |
Brugia malayi | hexokinase type II | 0.0373 | 0.3073 | 0.3029 |
Onchocerca volvulus | 0.1172 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1172 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.1172 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1172 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.1172 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.0301 | 0.0238 |
Brugia malayi | Hexokinase family protein | 0.0735 | 0.6216 | 0.6191 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0065 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0065 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0291 | 0.0283 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.0301 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.0301 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.3073 | 0.3067 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0009 | 0.139 |
Onchocerca volvulus | 0.1172 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.0301 | 0.0292 |
Plasmodium falciparum | protein kinase 5 | 0.0053 | 0.0301 | 0.0292 |
Echinococcus multilocularis | hexokinase | 0.1172 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0301 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.1172 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0065 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0065 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0053 | 0.0301 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0065 | 0.0056 |
Brugia malayi | Hexokinase family protein | 0.1172 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.123 | 0.1222 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0301 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.123 | 0.0957 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0053 | 0.0301 | 0.0238 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0065 | 1 |
Onchocerca volvulus | 0.0735 | 0.6216 | 0.6191 | |
Treponema pallidum | hexokinase (hxk) | 0.1172 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0735 | 0.6216 | 0.6212 |
Entamoeba histolytica | hexokinase 2 | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0053 | 0.0301 | 0.0292 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0065 | 1 |
Toxoplasma gondii | hexokinase | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.123 | 0.1222 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0.0301 | 0.0238 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0301 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0363 | 0.2987 | 0.2981 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.123 | 0.0957 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.0301 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.0301 | 0.0238 |
Onchocerca volvulus | 0.1172 | 1 | 1 | |
Echinococcus multilocularis | hexokinase type 2 | 0.1172 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0009 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0065 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.1172 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1172 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0065 | 1 |
Echinococcus granulosus | hexokinase | 0.1172 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1172 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1172 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.1172 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0735 | 0.6216 | 0.6191 |
Plasmodium vivax | protein kinase Crk2 | 0.0053 | 0.0301 | 0.0292 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.123 | 0.1173 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.123 | 0.0957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibitory concentration against cyclin-dependent kinase 4 | ChEMBL. | 12941312 |
IC50 (binding) | = 1 uM | Inhibitory concentration against cyclin-dependent kinase 4 | ChEMBL. | 12941312 |
IC50 (binding) | > 10 uM | Inhibitory concentration against cyclin-dependent kinase 2 | ChEMBL. | 12941312 |
IC50 (binding) | > 10 uM | Inhibitory concentration against cyclin-dependent kinase 2 | ChEMBL. | 12941312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.